55. Near-infrared fluorescence sentinel lymph node mapping in patients with muscle-invasive bladder cancer

2014 ◽  
Vol 40 (11) ◽  
pp. S30 ◽  
Author(s):  
H.J.M. Handgraaf ◽  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
H.W. Elzevier ◽  
Q.R.J.G. Tummers ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Muscle Invasive

scholarly journals Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging

2014 ◽  
Vol 110 (7) ◽  
pp. 845-850 ◽  
Author(s):  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
H.W. Elzevier ◽  
Q.R.J.G. Tummers ◽  
J.R. van der Vorst ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Near Infrared Fluorescence Imaging

scholarly journals Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma

2012 ◽  
Vol 168 (1) ◽  
pp. 93-98 ◽  
Author(s):  
J.R. van der Vorst ◽  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
R.J. Swijnenburg ◽  
M. Hutteman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Dose Optimization ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping

scholarly journals A Fluorescently-labeled Tumor-specific Peptide for Intraoperative Visualization of Non-muscle Invasive Bladder Cancer: A Clinical Study

2021 ◽  
Author(s):  
Wenting Shang ◽  
Li Peng ◽  
Kunshan He ◽  
Pengyu Guo ◽  
Han Deng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Histopathological Examination ◽  
Infrared Light ◽  
Invasive Bladder Cancer ◽  
Near Infrared Imaging ◽  
Muscle Invasive Bladder Cancer ◽  
Near Infrared Fluorescence ◽  
Muscle Invasive

Abstract Bladder cancer is the fifth most common malignancy in humans. Cystoscopy under white light imaging is the gold standard for bladder cancer diagnosis, but these tumors are difficult to visualize and can be overlooked, resulting in high recurrence rates. We previously developed a phage display-derived peptide-based near-infrared imaging probe, PLSWT7-DMI, which binds specifically to bladder cancer cells and is nontoxic to animals. Here, we report the first-in-human application of this probe for near-infrared fluorescence endoscopic detection of bladder cancer. The purity, efficacy, safety, and nontoxicity of the probe were confirmed prior to its clinical application. Twenty-two patients diagnosed with suspected non-muscle invasive bladder cancer were enrolled in the present study. Following intravesical administration of the probe, the entire mucosa was imaged under white and near-infrared imaging using an in-house developed endoscope that could switch between these two modes. The illuminated lesions under near-infrared light were biopsied and sent for histopathological examination. We observed a 5.1-fold increase in the fluorescence intensity in the tumor samples compared to normal tissue, and the probe demonstrated a sensitivity and specificity of 91.2% and 90%, respectively. Common diagnostic challenges, such as small satellite tumors, carcinoma in situ , and benign suspicious mucosa, were visualized and could be distinguished from cancer. Further, no adverse effects were observed in humans. These first-in-human results indicate that PLSWT7-DMI-based near-infrared fluorescence endoscopy is a safe and effective approach for the improved detection of bladder cancer, and may enable thorough resection to prevent recurrence.

scholarly journals A Clinical Study of A CD44v6-targeted Fluorescent Agent for the Detection of Non-muscle Invasive Bladder Cancer

2021 ◽  
Author(s):  
Wenting Shang ◽  
Li Peng ◽  
Kunshan He ◽  
Pengyu Guo ◽  
Han Deng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Histopathological Examination ◽  
Infrared Light ◽  
Invasive Bladder Cancer ◽  
Near Infrared Imaging ◽  
Muscle Invasive Bladder Cancer ◽  
Near Infrared Fluorescence ◽  
Muscle Invasive

Abstract Purpose Bladder cancer is the fifth most common malignancy in humans. Cystoscopy under white light imaging is the gold standard for bladder cancer diagnosis, but some tumors are difficult to visualize and can be overlooked, resulting in high recurrence rates. Method: We developed a phage display-derived peptide-based near-infrared imaging probe, PLSWT7-DMI, which binds specifically to bladder cancer cells and is nontoxic to animals. Here, we report a clinical research of this probe for near-infrared fluorescence endoscopic detection of bladder cancer. Results The purity, efficacy, safety, and nontoxicity of PLSWT7-DMI were confirmed prior to its clinical application. Twenty-two patients diagnosed with suspected non-muscle invasive bladder cancer were enrolled in the present study. Following intravesical administration of the probe, the entire mucosa was imaged under white and near-infrared imaging using an in-house developed endoscope that could switch between these two modes. The illuminated lesions under near-infrared light were biopsied and sent for histopathological examination. We observed a 5.1-fold increase in the fluorescence intensity in the tumor samples compared to normal tissue, and the probe demonstrated a sensitivity and specificity of 91.2% and 90%, respectively. Common diagnostic challenges, such as small satellite tumors, carcinoma in situ, and benign suspicious mucosa, were visualized and could be distinguished from cancer. Further, no adverse effects were observed in humans. Conclusion These first-in-human results indicate that PLSWT7-DMI-based near-infrared fluorescence endoscopy is a safe and effective approach for the improved detection of bladder cancer, and may enable thorough resection to prevent recurrence.

scholarly journals 90. Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer

2012 ◽  
Vol 38 (9) ◽  
pp. 760
Author(s):  
B.E. Schaafsma ◽  
J.R. van der Vorst ◽  
F.P.R. Verbeek ◽  
A.A.W. Peters ◽  
C.D. de Kroon ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping

scholarly journals Clinical Translation of Ex Vivo Sentinel Lymph Node Mapping for Colorectal Cancer Using Invisible Near-Infrared Fluorescence Light

2010 ◽  
Vol 18 (4) ◽  
pp. 1006-1014 ◽  
Author(s):  
Merlijn Hutteman ◽  
Hak Soo Choi ◽  
J. Sven D. Mieog ◽  
Joost R. van der Vorst ◽  
Yoshitomo Ashitate ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Ex Vivo ◽  
Sentinel Lymph Node Mapping ◽  
Clinical Translation ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Fluorescence Light
Sign in / Sign up

Export Citation Format

Share Document