N-Heterocyclic Carbene/Magnesium Co-catalyzed Radical Relay Assembly of Aliphatic Keto-nitriles
Keyword(s):
An N-heterocyclic carbene and magnesium co-catalyzed three-component alkylacylation of alkenes with cycloketone oxime esters and aldehydes was presented. This method displayed good scope generality, providing a transition metal and photo-redox free pathway to access various multi-functionalized aliphatic keto-nitrile structures under mild reaction conditions. Moreover, this strategy is supposed to follow a radical relay mechanism via a single electron transfer (SET) event of Mg/oxime ester/Breslow intermediate ternary electron donating acceptor (EDA) complex.
2019 ◽
Vol 37
(11)
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pp. 1130-1141
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1974 ◽
Vol 96
(22)
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pp. 7117-7119
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1986 ◽
Vol 108
(24)
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pp. 7763-7767
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Keyword(s):