scholarly journals N-Heterocyclic Carbene/Magnesium Co-catalyzed Radical Relay Assembly of Aliphatic Keto-nitriles

Author(s):  
Lei Chen ◽  
Shiyi Jin ◽  
Jian Gao ◽  
Tongtong Liu ◽  
Yuebo Shao ◽  
...  

An N-heterocyclic carbene and magnesium co-catalyzed three-component alkylacylation of alkenes with cycloketone oxime esters and aldehydes was presented. This method displayed good scope generality, providing a transition metal and photo-redox free pathway to access various multi-functionalized aliphatic keto-nitrile structures under mild reaction conditions. Moreover, this strategy is supposed to follow a radical relay mechanism via a single electron transfer (SET) event of Mg/oxime ester/Breslow intermediate ternary electron donating acceptor (EDA) complex.

2020 ◽  
Author(s):  
Lei Chen ◽  
Shiyi Jin ◽  
Jian Gao ◽  
Tongtong Liu ◽  
Yuebo Shao ◽  
...  

An N-heterocyclic carbene and magnesium co-catalyzed three-component alkylacylation of alkenes with cycloketone oxime esters and aldehydes was presented. This method displayed good scope generality, providing a transition metal and photo-redox free pathway to access various multi-functionalized aliphatic keto-nitrile structures under mild reaction conditions. Moreover, this strategy is supposed to follow a radical relay mechanism via a single electron transfer (SET) event of Mg/oxime ester/Breslow intermediate ternary electron donating acceptor (EDA) complex.


Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 459 ◽  
Author(s):  
Hengzhao Li ◽  
Zemin Lai ◽  
Adila Adijiang ◽  
Hongye Zhao ◽  
Jie An

Functionalization of amide bond via the cleavage of a non-carbonyl, C-N σ bond remains under-investigated. In this work, a transition-metal-free single-electron transfer reaction has been developed for the C-N σ bond cleavage of N-acylazetidines using the electride derived from sodium dispersions and 15-crown-5. Of note, less strained cyclic amides and acyclic amides are stable under the reaction conditions, which features the excellent chemoselectivity of the reaction. This method is amenable to a range of unhindered and sterically encumbered azetidinyl amides.


ChemInform ◽  
2014 ◽  
Vol 45 (42) ◽  
pp. no-no
Author(s):  
Suresh Kumar Sythana ◽  
Santhosh Unni ◽  
Yogesh M. Kshirsagar ◽  
Pundlik R. Bhagat

2021 ◽  
Vol 23 (5) ◽  
pp. 1714-1719
Author(s):  
Linlin Zhang ◽  
Zhengfen Liu ◽  
Xun Tian ◽  
Yujin Zi ◽  
Shengzu Duan ◽  
...  

2021 ◽  
Author(s):  
Qian Dou ◽  
Li Geng ◽  
Bin Cheng ◽  
Chao-Jun Li ◽  
Huiying Zeng

Photoinduced phosphonation of aryl triflates with trialkyl phosphites via a tandem single-electron-transfer, C–O bond cleavage and Arbuzov rearrangement process in the absence of transition-metal and external photosensitizer is reported herein....


Sign in / Sign up

Export Citation Format

Share Document