Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by a Dual “N–H Effect”
Keyword(s):
<p>The first example of non-noble metal-catalyzed asymmetric hydrogenation of aromatic <i>N</i>-heterocycles is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asymmetric hydrogenation of a wide range of quinolines, affording high yields and excellent enantioselectivities (up to 97% <i>ee</i>). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which was competitive with the activity of most effective noble metal catalysts for this reaction. The high reactivity of the manganese catalyst and a precise regulation of the enantioselectivity were ensured by a dual “N–H” effect of the ligand structure.<u></u></p>
2020 ◽
2020 ◽
2012 ◽
Vol 8
◽
pp. 699-704
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2017 ◽
Vol 117
(17)
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pp. 11522-11569
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Keyword(s):