Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports
Keyword(s):
<p>The standard methodology for the synthesis of oligonucleotides is the solid-phase method. Here, we report the first case of mechanochemistry being directly applied to the synthesis of a dinucleotide on a soluble support. While mechanochemistry eliminates the need to solubilise a supported oligomer in solution phase for phosphoramidite coupling, the support still confers the benefit of being able to purify the product by precipitation, or by simple liquid-liquid extractions as needed. Furthermore, this study also explores the use of mechanochemistry in the initial functionalisation of the ionic liquid support with a nucleoside monomer.</p>
1988 ◽
Vol 53
(11)
◽
pp. 2914-2919
◽
Keyword(s):
1991 ◽
Vol 56
(2)
◽
pp. 491-498
◽
1981 ◽
Vol 362
(2)
◽
pp. 833-840
◽
2001 ◽
Vol 10
(2)
◽
pp. 89-92
◽
Keyword(s):
1994 ◽
Vol 59
(2)
◽
pp. 461-466
◽
Keyword(s):
Keyword(s):