A Bio-Based Alginate Aerogel as an Ionic Liquid Support for the Efficient Synthesis of Cyclic Carbonates from CO2 and Epoxides

In this work, the ionic liquid [Aliquat][Cl] was supported into alginate and silica aerogel matrices and applied as a catalyst in the cycloaddition reaction between CO2 and a bio-based epoxide (limonene oxide). The efficiency of the alginate aerogel system is much higher than that of the silica one. The method of wet impregnation was used for the impregnation of the aerogel with [Aliquat][Cl] and a zinc complex. The procedure originated a well-defined thin solvent film on the surface of support materials. Final materials were characterised by Fourier Transform Infrared Spectroscopy, N2 Adsorption–Desorption Analysis, X-ray diffraction, atomic absorption and Field Emission Scanning Microscopy. Several catalytic tests were performed in a high-pressure apparatus at 353.2 K and 4 MPa of CO2.

Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports

<p>The standard methodology for the synthesis of oligonucleotides is the solid-phase method. Here, we report the first case of mechanochemistry being directly applied to the synthesis of a dinucleotide on a soluble support. While mechanochemistry eliminates the need to solubilise a supported oligomer in solution phase for phosphoramidite coupling, the support still confers the benefit of being able to purify the product by precipitation, or by simple liquid-liquid extractions as needed. Furthermore, this study also explores the use of mechanochemistry in the initial functionalisation of the ionic liquid support with a nucleoside monomer.</p>

Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports

<p>The standard methodology for the synthesis of oligonucleotides is the solid-phase method. Here, we report the first case of mechanochemistry being directly applied to the synthesis of a dinucleotide on a soluble support. While mechanochemistry eliminates the need to solubilise a supported oligomer in solution phase for phosphoramidite coupling, the support still confers the benefit of being able to purify the product by precipitation, or by simple liquid-liquid extractions as needed. Furthermore, this study also explores the use of mechanochemistry in the initial functionalisation of the ionic liquid support with a nucleoside monomer.</p>

Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale

A hetero-branched N-glycan core pentasaccharide was rapidly assembled on a new ionic liquid support on a 10 g scale.

Coupling oligonucleotides possessing a poly-cytosine tag with magnetic ionic liquids for sequence-specific DNA analysis

Oligonucleotide probes containing a poly-cytosine region have remarkable affinity to a magnetic ionic liquid support and are used to distinguish single-nucleotide variants and capture DNA targets for qPCR amplification.