Functional Switching of a Native Neuropeptide Through Interactions with Pathogenic Factors in Dementia
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We discovered that the function of a native neuropeptide, somatostatin (SST), is switched through its conformational transition in the presence of metal ions, metal-free amyloid-beta (Abeta), and metal-bound Abeta that are associated with toxicity observed in the brains of Alzheimer’s disease patients.
2021 ◽
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1997 ◽
Vol 23
(4)
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pp. 322-325
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