Formation of Neutral Peptide Aggregates Studied by Mass Selective IR Action Spectroscopy

2019 ◽  
Author(s):  
Sjors Bakels ◽  
Sebastiaan Porskamp ◽  
Anouk Rijs
Keyword(s):  
Gas Phase ◽  
Self Assembly ◽  
Molecular Beam ◽  
Structural Changes ◽  
Uv Spectroscopy ◽  
Laser Desorption ◽  
Charged Species ◽  
Neutral Peptide ◽  
Proteins And Peptides

The spontaneous aggregation of proteins and peptides is widely studied due to its relation to neurodegenerative diseases. To understand the underlying principles of peptide aggregation, elucidation of structure and structural changes upon their formation is key. This level of detail can be obtained by studying the peptide self-assembly in the gas phase. Structural characterization of aggregates is mainly done on charged species, as adding charges is an intrinsic part of the technique to bring molecules into the gas phase. Studying neutral peptide aggregates will complement the existing picture. These studies are restricted to dimers due to experimental limitations. Here, we present advances in laser desorption molecular beam spectroscopy to form neutral peptide aggregates in the gas phase consisting of up to fourteen monomeric peptides. The combination with IR-UV spectroscopy allowed us to select each aggregate by size and subsequently characterize its structure.

Formation of Neutral Peptide Aggregates Studied by Mass Selective IR Action Spectroscopy

2019 ◽  
Author(s):  
Sjors Bakels ◽  
Sebastiaan Porskamp ◽  
Anouk Rijs
Keyword(s):  
Gas Phase ◽  
Self Assembly ◽  
Molecular Beam ◽  
Structural Changes ◽  
Uv Spectroscopy ◽  
Laser Desorption ◽  
Charged Species ◽  
Neutral Peptide ◽  
Proteins And Peptides

The spontaneous aggregation of proteins and peptides is widely studied due to its relation to neurodegenerative diseases. To understand the underlying principles of peptide aggregation, elucidation of structure and structural changes upon their formation is key. This level of detail can be obtained by studying the peptide self-assembly in the gas phase. Structural characterization of aggregates is mainly done on charged species, as adding charges is an intrinsic part of the technique to bring molecules into the gas phase. Studying neutral peptide aggregates will complement the existing picture. These studies are restricted to dimers due to experimental limitations. Here, we present advances in laser desorption molecular beam spectroscopy to form neutral peptide aggregates in the gas phase consisting of up to fourteen monomeric peptides. The combination with IR-UV spectroscopy allowed us to select each aggregate by size and subsequently characterize its structure.

scholarly journals Self Assembly of semiconductor nanostructures

Respuestas ◽  
2016 ◽  
Vol 12 (2) ◽  
pp. 47-51
Author(s):  
Máximo López-López ◽  
Esteban Cruz-Hernández ◽  
Isaac Martínez-Velis ◽  
Juan Salvador Rojas-Ramírez ◽  
Manolo Ramirez-Lopez ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Molecular Beam Epitaxy ◽  
Self Assembly ◽  
Molecular Beam ◽  
Quantum Wires ◽  
Preferential Growth ◽  
Growth Method ◽  
Strong Surface ◽  
Self Assembled

 Abstract In this work we present the growth and characterization of GaAs self-assembled quantum wires (SAQWRs), and InAs self-assembled quantum dots (SAQDs) by molecular beam epitaxy on (631)-oriented GaAs substrates. Adatoms on the (631) crystal plane present a strong surface diffusion anisotropy which we use to induce preferential growth along one direction to produce SAQWRs. On the other hand, InAs SAQDs were obtained on GaAs(631) with SAQWRs by the Stransky–Krastanov (S-K) growth method. SAQDs grown directly on (631) substrates presented considerable fluctuations in size. We study the effects of growing a stressor layer before the SAQDs formation to reduce these fluctuations.Keywords : Quantum wires, quantum dots; selfassembly; molecular beam epitaxy.

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