scholarly journals A Convenient Two-Step Synthesis of Coenzyme Q1

2019 ◽  
Author(s):  
Yi-Yu Yan ◽  
Wan-Yue Luo ◽  
Yan Zhao ◽  
Jian-Hua Tian ◽  
Jin Wang
Keyword(s):  
Convenient Method ◽  
Allyl Bromide ◽  
Coenzyme Q ◽  
Chain Reaction ◽  
Step Procedure ◽  
Redox Chain ◽  
Moderate Yield

<p>A convenient method for the preparation of Coenzyme Q<sub>1</sub> from the cheap and readily available 3,4,5-Trimethoxytoluene was developed. CoQ<sub>1 </sub>was synthesized in moderate yield by a two-step procedure involving the key reaction of allyl bromide with CoQ<sub>0 </sub>through a redox chain reaction. The reaction is efficient and could be used for the synthesis of other CoQ compounds.</p>

scholarly journals A Convenient Two-Step Synthesis of Coenzyme Q1

2019 ◽  
Author(s):  
Yi-Yu Yan ◽  
Wan-Yue Luo ◽  
Yan Zhao ◽  
Jian-Hua Tian ◽  
Jin Wang
Keyword(s):  
Convenient Method ◽  
Allyl Bromide ◽  
Coenzyme Q ◽  
Chain Reaction ◽  
Step Procedure ◽  
Redox Chain ◽  
Moderate Yield

<p>A convenient method for the preparation of Coenzyme Q<sub>1</sub> from the cheap and readily available 3,4,5-Trimethoxytoluene was developed. CoQ<sub>1 </sub>was synthesized in moderate yield by a two-step procedure involving the key reaction of allyl bromide with CoQ<sub>0 </sub>through a redox chain reaction. The reaction is efficient and could be used for the synthesis of other CoQ compounds.</p>

A convenient two-step synthesis of Coenzyme Q1

2019 ◽  
Vol 43 (11-12) ◽  
pp. 553-556
Author(s):  
Bin Lu ◽  
Yong-Fu Qiu ◽  
Shi Qi ◽  
Jin Wang
Keyword(s):  
Convenient Method ◽  
Allyl Bromide ◽  
Coenzyme Q ◽  
Chain Reaction ◽  
Step Procedure ◽  
Redox Chain ◽  
Moderate Yield

A convenient method for the preparation of Coenzyme Q1 from cheap and readily available 3,4,5-trimethoxytoluene is developed. Coenzyme Q1 is synthesized in a moderate yield by a two-step procedure involving the key reaction of an allyl bromide with Coenzyme Q0 through a redox chain reaction. The reaction is efficient and can be used for the synthesis of other Coenzyme Q compounds.

scholarly journals Detection of Enteroviruses in Shellfish by Fluorogenic Polymerase Chain Reaction Integrated with 96-Well Microplate Scanning

2002 ◽  
Vol 85 (5) ◽  
pp. 1045-1051 ◽  
Author(s):  
Y Carol Shiekh ◽  
Ralph S Baric
Keyword(s):  
Polymerase Chain Reaction ◽  
Detection Efficiency ◽  
Pcr Primers ◽  
Southern Analysis ◽  
Municipal Sewage ◽  
Chain Reaction ◽  
Step Procedure ◽  
Linear Probe ◽  
One Step ◽  
Polymerase Chain

Abstract A one-step procedure was developed to confirm viral targets by using a fluorometric 96-well microplate scanner following polymerase chain reaction (PCR). The fluorogenic PCR, integrated with fluorometric scanning, measured the end point fluorescence of viral PCR amplicon/probe hybrids and permitted the use of nonfluorogenic PCR conditions with addition of a Cy3 fluorophore-labeled linear probe for viruses. This linear probe generated higher ratios of viral signal-to-noise than a comparative beacon probe. Detection efficiency with a Cy3/quencher linear probe was comparable with Southern analysis at the level ≥0.27 plaque-forming units (PFU) of poliovirus/PCR. For the reaction containing &lt;0.27 PFU, the fluorometric measurements of the first-round PCR viral amplicon were not as sensitive as Southern analysis; however, equivalent sensitivities were achieved with fluorogenic nested PCR. Concentrates of 11 oyster samples exposed to municipal sewage were tested for enteroviruses; the fluorogenic detection correlated 100% with Southern analysis. This method using fluorometric scanning of viral amplicon is simple; it requires neither continuously monitoring equipment nor redesigning PCR primers; and it accurately detects enteroviruses in oyster sample concentrates in less time than classic spectrophotometry or Southern analysis.

scholarly journals Propargylation of CoQ0 through the Redox Chain Reaction

2021 ◽  
Author(s):  
Robert Pawlowski ◽  
Maciej Stodulski ◽  
Jacek Mlynarski
Keyword(s):  
Chain Reaction ◽  
Redox Chain

Deciphering the Redox Chain Mechanism in the Catalytic Alkylation of Quinones

Synlett ◽  
2018 ◽  
Vol 29 (14) ◽  
pp. 1807-1813 ◽  
Author(s):  
Zhi Li ◽  
Xiao-Long Xu
Keyword(s):  
Reaction Mechanism ◽  
Lewis Acid ◽  
Kinetic Studies ◽  
Chain Mechanism ◽  
Chain Reaction ◽  
Catalytic Alkylation ◽  
Redox Chain ◽  
Strong Lewis Acid ◽  
Acid Catalyzed ◽  
Alkylation Reactions

Alkylation of p-quinones with allylic and benzylic esters is achieved by using a strong Lewis acid as the catalyst. This transformation likely follows an unusual redox chain mechanism. In this mechanism, quinone undergoes a sequence of reactions: it is reduced to ­hydroquinone (HQ), functionalized in a Lewis acid-catalyzed Friedel–Crafts alkylation, and then oxidized back to quinone. The last step is concurrent with the first step of a second quinone molecule, which is reduced to new HQ and functionalized, and thus propagates the redox chain reaction. The autoinitiation mechanism of the redox chain is not well understood, but additive HQ or Hantzsch ester can serve as effective initiators. The likelihood of this mechanism was elaborated by ­kinetic studies and various control experiments.1 Introduction2 Discovery of Catalytic Alkylation Reactions of Quinones3 Proposed Redox Chain Reaction Mechanism and Experimental Evidence4 Substrate Scope5 Conclusion

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