Autonomous Control and Dynamics Simulation of a 3-Stages Countercurrent Liquid-Liquid Extraction: Trimetozine Purification as a Case Study

2019 ◽  
Author(s):  
Zied Hosni ◽  
Nazer Rajoub ◽  
Ian Houson ◽  
Alison Nordon ◽  
Brahim Benyahia ◽  
...  
Keyword(s):  
Process Analytical Technology ◽  
Liquid Extraction ◽  
Dynamics Simulation ◽  
Liquid Liquid Extraction ◽  
Full Control ◽  
Partial Least Squares Model ◽  
Three Stages ◽  
Analytical Technology ◽  
Washing Solvent

Liquid-liquid extraction is a technique of extraction heavily used in chemical industry and especially for purification of pharmaceuticals. Trimetozine was used as a case study to test the performance of an implemented platform capable of conducting the extraction of the analyte of interest from its impurities using a washing solvent. Three stages of pairs of mix-er-settler were designed for a full control of the streams flow rates, the temperature, and the speed of stirring. The countercurrent extraction was chosen with an inline IR sensor as a Process Analytical Technology and a Partial Least Squares model to quantify the partitioning of the different analytes in the downstream of the platform. The dynamics of the extraction was followed experimentally and simulated in MATLAB in order to build black-box model.

scholarly journals Autonomous Control and Dynamics Simulation of a 3-Stages Countercurrent Liquid-Liquid Extraction: Trimetozine Purification as a Case Study

2019 ◽  
Author(s):  
Zied Hosni ◽  
Nazer Rajoub ◽  
Ian Houson ◽  
Alison Nordon ◽  
Brahim Benyahia ◽  
...  
Keyword(s):  
Process Analytical Technology ◽  
Liquid Extraction ◽  
Dynamics Simulation ◽  
Liquid Liquid Extraction ◽  
Full Control ◽  
Partial Least Squares Model ◽  
Three Stages ◽  
Analytical Technology ◽  
Washing Solvent

Liquid-liquid extraction is a technique of extraction heavily used in chemical industry and especially for purification of pharmaceuticals. Trimetozine was used as a case study to test the performance of an implemented platform capable of conducting the extraction of the analyte of interest from its impurities using a washing solvent. Three stages of pairs of mix-er-settler were designed for a full control of the streams flow rates, the temperature, and the speed of stirring. The countercurrent extraction was chosen with an inline IR sensor as a Process Analytical Technology and a Partial Least Squares model to quantify the partitioning of the different analytes in the downstream of the platform. The dynamics of the extraction was followed experimentally and simulated in MATLAB in order to build black-box model.

scholarly journals Process analytical technology case study, part III: Calibration monitoring and transfer

2005 ◽  
Vol 6 (2) ◽  
pp. E284-E297 ◽  
Author(s):  
Robert P. Cogdill ◽  
Carl A. Anderson ◽  
James K. Drennen
Keyword(s):  
Process Analytical Technology ◽  
Analytical Technology

scholarly journals Advancement of process control using process analytical technology (PAT) in continuous biomanufacturing: Case study

2020 ◽  
Author(s):  
Sobhana Alekhya Sripada ◽  
Sushmitha Krishnan ◽  
Rajan Bhawnani ◽  
Jessica Molek ◽  
Aparajith Bhaskar ◽  
...  
Keyword(s):  
Process Control ◽  
Process Analytical Technology ◽  
Analytical Technology

scholarly journals Advancement of process control using process analytical technology (PAT) in continuous biomanufacturing: Case study

2020 ◽  
Author(s):  
Sobhana Alekhya Sripada ◽  
Sushmitha Krishnan ◽  
Rajan Bhawnani ◽  
Jessica Molek ◽  
Aparajith Bhaskar ◽  
...  
Keyword(s):  
Process Control ◽  
Process Analytical Technology ◽  
Analytical Technology

Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

2019 ◽  
Author(s):  
Zied Hosni ◽  
Ian Houson ◽  
Brahim Benyahia ◽  
Alastair Florence
Keyword(s):  
Steady State ◽  
Partition Coefficients ◽  
Industrial Process ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction ◽  
Steady State Model ◽  
Liquid Model ◽  
Steady State Simulation ◽  
Counter Current

The countercurrent liquid-liquid extraction is a crucial step in industrial process to purify and extract a compound of inter-ests for its impurities. This step requires generally challenging and time-consuming optimisation of numerous factors that affect the overall yield of extraction and the energy needed. The simulation of this process has been investigated in this pa-per using a Non-Random Two Liquid model implemented as a thermodynamic method in Aspen. The outcome of this model enables the evaluation of the partition coefficients of the different analytes of a mixtures at the different compart-ments of extraction platform. In addition, this steady-state model allows a more straightforward optimisation of the factors that drive the performance of extraction.

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