scholarly journals Antiviral therapy of chronic hepatitis C: 30 years success story

2019 ◽  
Vol 91 (11) ◽  
pp. 110-115
Author(s):  
D T Abdurakhmanov ◽  
T P Rozina ◽  
E N Nikulkina ◽  
E Z Burnevich ◽  
E L Tanashuk ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Antiviral Action ◽  
Success Story ◽  
Treatment Regimens ◽  
The Past ◽  
C 30

Exactly 30 years ago, hepatitis C virus was identified. Over the years, tremendous success has been achieved in the treatment of hepatitis C, which is currently considered to be an almost completely curable disease. The review presents the main stages in the development of hepatitis C antiviral therapy, the efficacy of various treatment regimens. The greatest progress in treatment was noted over the past 5 years when drugs with direct antiviral action appeared and began to be widely used, including in Russia, which ensure the elimination of the virus in 90-95% of cases.

Changes in Serum Level of Autotaxin with Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Khaled Mohamed Hussein Abdelwahab ◽  
Shereen Abou Bakr Saleh ◽  
Ghada Abdelrahman Ahmed ◽  
Asmaa Mady Gomaa Mady
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serum Level ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Post Treatment ◽  
Direct Acting Antiviral ◽  
Direct Acting

Abstract Background Hepatitis C virus virus is global health burden and major health hazard in Egypt, since the virus is the etiological factor of chronic hepatitis. Hepatitis C virus (HCV) accounts for approximately 15%-20% cases of acute hepatitis. After acute infection, around 50% to 80% of HCV patients will develop chronic infection. Approximately, HCV infects 170 million individuals worldwide). Chronic hepatitis C (CHC) patients are at high risk to develop lifethreatening complications, including cirrhosis in 20% of cases and hepatocellular carcinoma. Objectives The aim of this study was to validate Changes in serum level of autotaxin in patients with chronic hepatitis C before and after antiviral treatment. Patients and methods This study was designed as a prospective observational cohort study to evaluate Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C before (baseline) and after (sustained virologic response week 12) treatment. This prospective study was conducted on 48 chronic HCV infected patients eligible for antiviral treatment with direct acting antivirals, agreeable to regular follow up, recruited from Hepatology and virology outpatient clinic at DMNI (Damanhour Medical National Institute) during the period from September 2018 till Mars 2019. Results This study showed that Autotaxin level significantly decreased from baseline to 12 weeks post-treatment. ATX therefore represents a novel non-invasive biomarker for liver fibrosis and a prognostic indicator of disease activity. Conclusion Serum Autotaxin was found to be higher in chronic hepatitis c and ATX levels became significantly decreased from baseline to 12 weeks post-treatment with direct acting antiviral drugs in patients achieving a SVR.

scholarly journals Clinical and epidemiological characteristics of chronic hepatitis C virus infection in elderly patients

2014 ◽  
Vol 67 (suppl. 2) ◽  
pp. 39-43
Author(s):  
Tomislav Preveden ◽  
Milos Vujanovic ◽  
Maja Ruzic ◽  
Nadica Kovacevic ◽  
Radoslava Doder ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiviral Therapy ◽  
Elderly People ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Epidemiological Characteristics

Introduction. Chronic hepatitis C virus infection in elderly people has not been widely studied although an increase in the prevalence of this disease in the older population is expected. Material and Methods. This work presents the clinical and epidemiological characteristics of chronic hepatitis C in 153 patients aged 65 years and older who were treated at the Department of Infectious Diseases, Clinical Center of Vojvodina in Novi Sad. Results. Hepatitis C virus infection is slightly more prevalent in women - 55.55%; it is usually discovered accidentally during other examinations and is usually acquired after blood transfusion - 42.48% of cases. The average duration of infection was 28.48 years, the most common infection was caused by genotype 1 of the hepatitis C virus and histopathological examinations of liver biopsy usually revealed severe fibrosis and cirrhosis - 72.22% of cases. The success of the antiviral therapy applied in 16 patients was 62.50%. Conclusion. Antiviral therapy in elderly people is rarely used, but the success of 62.50% in our sample justifies the treatment of patients despite their age and comorbidities.

scholarly journals Long-term Antiviral Hepatitis C treatment associated with Rods and Ring Cytoplasmic antibodies

2019 ◽  
Vol 92 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Vasile Feldrihan ◽  
Andreea Benea ◽  
Monica Lia Junie
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Clinical Case ◽  
Biological Evaluation ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

Aim. Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".Method. Clinical case report.Results. A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response.Conclusion. This is the first reported clinical case of a patient with cytoplasmic filamentous rods and rings autoantibodies associated with chronic hepatis C from the Clinical Hospital IRGH Prof. Dr. O. Fodor Cluj-Napoca, Romania. The presence of these antibodies appears to be triggered by antiviral therapy. Although these are newly identified antibodies, they could be used as serological markers for detecting patients at risk of developing associated autoimmune pathologies or nonresponders to the antiviral therapy. Likewise, their detection could identify patients with occult hepatitis C infection.

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