scholarly journals Comparison of the effectiveness of preparations containing moxonidine during emergency antihypertensive therapy

2015 ◽  
Vol 12 (2) ◽  
pp. 8-12
Author(s):  
V V Ruksin ◽  
O V Grishin ◽  
M V Onuchin

In 163 patients we compared the therapeutic efficacy and safety of a single sublingual original moxonidine (Fiziotenz, Abbott) and generic moxonidine (Tenzotran, Actavis Group) in the provision of emergency medical services in the case of high blood pressure. It was found that the original moxonidine (Fiziotenz) and generic moxonidine (Tenzotran) are effective to provide emergency medical services with an increase in blood pressure, especially in patients with hypersympathicotonia. At the same time, generic Tenzotran lowers blood pressure less and later than Fiziotenz, the original drug. Adverse effects after using both drugs were not expressed and rare.

Sleep Health ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 387-398 ◽  
Author(s):  
P. Daniel Patterson ◽  
Kristina A. Mountz ◽  
Caitlin T. Budd ◽  
Jenna L. Bubb ◽  
Austin U. Hsin ◽  
...  

2021 ◽  
Vol 22 (1) ◽  
pp. 32-39
Author(s):  
О. V. Grishsin

In 91 patients with increased blood pressure, the efficacy and safety of three combinations of antihypertensive drugs was clarified. It was proved that the use of hourly monitoring of changes in blood pressure immediately after the provision of emergency therapy with the help of sublingual use of combinations of antihypertensive drugs allows for objective control of the time of onset and duration of the preservation of the therapeutic effect and to assess the likelihood and severity of repeated increase and excessive decrease in blood pressure. It has been shown that combinations of antihypertensive drugs: captopril with furosemide, moxonidine with furosemide and moxonidine with nifedipine are not only highly effective, but also safe, and therefore can be used by a doctor or paramedic of emergency medical care to provide emergency therapy, even in elderly and senile patients with comorbid pathology. 


1995 ◽  
Vol 10 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Douglas M. Wolfberg ◽  
Vincent P. Verdile ◽  
Richard D. Flinn

AbstractThe proliferation of new medical technology and pharmacology forces the medical community to ensure the efficacy and safety of new drugs and devices before their use in patient care. Although traditional medical practices have a fairly consistent means to achieve this end, prehospital medical practice often does not. In addition, it often appears that the emergency medical services marketplace does not always follow conventional supply/demand and cost/quality paradigms. This article describes a process implemented in Pennsylvania to standardize the mechanism by which new drugs and devices are introduced into prehospital medical practice.


1996 ◽  
Vol 11 (2) ◽  
pp. 105-107 ◽  
Author(s):  
Brendan McCluskey ◽  
Michael Addis ◽  
Bartholomew J. Tortella ◽  
Robert F. Lavery

AbstractStudy objective:Blood pressure (BP) in the out-of-hospital setting is one of the most important diagnostic tools used by emergency medical services (EMS) providers. Conventional methods of palpation and auscultation can be time consuming, and the measurements often are inaccurate because of the adverse working conditions encountered. Pulse oximetry waveform systolic blood pressure (POWSBP) measurement has been used successfully in emergency departments to monitor BP. The objective of this study was to compare the accuracy of field POWSBP measurements obtained by noninvasive electronic BP measurement (NIBPM), auscultation, and palpation in the out-of-hospital environment.Design:Blood pressure measurements used for this study were obtained by POWSBP, NIBPM (PROPAQ model 102; Protocol Systems, Beaverton, Oregon USA), auscultation, and palpation on patients in moving ambulances. Measurement of POWSBP was accomplished by observing the return of the waveform on the pulse oximeter at the time of cuff deflation. The order in which the readings were obtained as well as the arm chosen for measurement were randomized.Setting and participants:Paramedics and emergency medical technicians in an urban, inner-city emergency medical services (EMS) system.Measurements and main results:Bloopressure measurements were sampled from 69 patients. Regression analysis identified significant correlation between POWSBP and the four methods utilized, with r = 0.92 for NIPBM, r = 0.95 for auscultation, and r = 0.97 for palpation, all significant at p<0.0001.Conclusions:The use of POWSBP measurement is a fast, easy, and accurate technique with which to measure systolic BP in the field. It may have special importance for noisy environments and moving vehicles in which conventional methods of auscultation or palpation may be difficult.


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