scholarly journals Oral mucosal lesions in children with and without cleft lip and palate: a case control study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1233-1238
Author(s):  
Yashila Periyasamy ◽  
Vignesh Ravindran ◽  
Subhashini V C
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Orofacial Clefts ◽  
Major Health Problem ◽  
Major Health ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions ◽  
Nasal Regurgitation ◽  
Control Study

Orofacial clefts are a major health problem affecting individuals worldwide. Affected children would be having functional and aesthetic problems, such as breastfeeding difficulties due to improper oral seal and nasal regurgitation. Hearing and speech difficulties are also associated with the aperture. Oral mucosal lesions are commonly missed due to higher concern over the cleft than the minority of these conditions. The purpose of the study was to assess the presence or absence of oral mucosal lesions in children with and without cleft lip and palate. A total of 89000 cases were reviewed between June 2019 to March 2020 for the incidence of oral mucosal lesions in individuals with and without cleft lip and palate only. The present study consists of 30 children divided into two groups: children with cleft lip and palate and children without cleft lip and palate. In both groups, the presence of oral mucosal lesions was noted. Absence of oral mucosal lesions in both children with cleft lip and palate and children without cleft lip and palate. In this study, there is no evidence regarding oral mucosal lesions in children with and without cleft lip and palate.

scholarly journals The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods

2021 ◽  
pp. 105566562110189
Author(s):  
Allyn Auslander ◽  
Roberta McKean-Cowdin ◽  
Devin Feigelson ◽  
Frederick Brindopke ◽  
Melissa DiBona ◽  
...  
Keyword(s):  
Risk Factors ◽  
Biological Samples ◽  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Family Study ◽  
Case Control ◽  
Local Health ◽  
Orofacial Clefts ◽  
Control Study

Background: The majority of research to understand the risk factors of nonsyndromic orofacial clefts (NSOFCs) has been conducted in high-income populations. Although patients with NSOFCs in low- and middle-income countries (LMICs) are at the highest risk of not receiving care, global health infrastructure allows innovative partnerships to explore the etiologic mechanisms of cleft and targets for prevention unique to these populations. Methods: The International Family Study (IFS) is an ongoing case–control study with supplemental parental trio data designed to examine genetic, environmental, lifestyle, and sociodemographic risk factors for NSOFCs in 8 LMICs (through August 2020). Interview and biological samples are collected for each family. The interview includes demographics, family history of cleft, diet and water sources, maternal pregnancy history, and other lifestyle and environmental factors. Results: Seven of 8 countries are currently summarized (2012-2017) for a total of 2955 case and 2774 control families with 11 946 unique biological samples from Vietnam, Philippines, Honduras, Madagascar, Morocco, Democratic Republic of the Congo, and Nicaragua. The phenotype distribution was 1641 (55.5%) cases with cleft lip and palate, 782 (26.5%) with cleft lip (CL), and 432 (14.6%) with cleft palate (CP). Discussion: The International Family Study is the largest case set of NSOFCs with an associated biobank in LMICs currently assembled. The biobank, family, and case–control study now include samples from 8 LMICs where local health care infrastructure cannot address the surgical burden of cleft or investigate causal mechanisms. The International Family Study can be a source of information and may collaborate with local public health institutions regarding education and interventions to potentially prevent NSOFCs.

Occlusal, chewing, and tasting characteristics associated with orofacial dysfunctions in children with unilateral cleft lip and palate: a case-control study

2017 ◽  
Vol 22 (2) ◽  
pp. 941-950 ◽  
Author(s):  
Ana Bheatriz Marangoni Montes ◽  
Thais Marchini de Oliveira ◽  
Maria Beatriz Duarte Gavião ◽  
Taís de Souza Barbosa
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Case Control ◽  
Control Study

scholarly journals Parental age and the risk of cleft lip and palate in a Nigerian population - A case–control study

2020 ◽  
Vol 10 (2) ◽  
pp. 429
Author(s):  
Olutayo James ◽  
OlufemiA Erinoso ◽  
AjokeO Ogunlewe ◽  
WasiuL Adeyemo ◽  
AkinolaL Ladeinde ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Case Control ◽  
Parental Age ◽  
Nigerian Population ◽  
Control Study

scholarly journals Three-Dimensional Outcome Assessments of Surgical Correction in Cleft and Noncleft Patients with Class III Skeletal Relation: A Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Te-Ju Wu ◽  
Cheng-Chun Wu ◽  
Chi-Yu Tsai ◽  
Yi-Hao Lee ◽  
Yu-Jen Chang ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Vertical Movement ◽  
Case Control ◽  
Class Iii ◽  
Vertical Movements ◽  
Receiver Operating Characteristic Curves ◽  
Control Study

Background. The orthognathic strategies to treat patients with a concave profile but different tissue conditions remain controversial. The aim of this case-control study was to investigate the outcome predictability of orthognathic surgery in cleft lip and palate (CLP) patients and matched controls. Methods. Fifty consecutive CLP and 45 matched non-CLP patients who received whole-piece Le Fort I and bilateral sagittal split osteotomy to correct class III skeletal relations were enrolled. The outcome discrepancies (ODs) from simulations among all groups were evaluated with consideration of the possible influences from planned surgical movements (PSM). Receiver operating characteristic curves were used to determine threshold values of PSMs that yielded clinically relevant OD. Results. Unilateral CLP (UCLP) patients had comparable postsurgical OD to non-CLP patients in both jaws, whereas bilateral CLP (BCLP) patients had greater deviations from predicted results. Vertical movement of the A − point > 1.33   mm and yaw   correction > 1.65 ° in the BCLP patients was associated with clinically relevant maxillary OD. Conclusions. The OGS outcomes of BCLP patients were less predictable than those of the UCLP and noncleft patients. Vertical movements of the A − point > 1.33   mm and yaw   correction > 1.65 ° in BCLP patients increased OD to a clinically relevant extent.

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