Immunohistochemical expression of endocan, as a marker of assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region

BACKGROUND: Vascular tumors are a heterogeneous group of diseases with biological behavior ranging from a hamartomatous growth to frank malignant. The pathophysiology of lymphangioma, vascular malformation and hemangioma is interconnected, blood vessels known to be the site of origin of hamartomas, venous malformations and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Angiogenesis is the process of formation of new blood vessels from an existing structure. Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region. Materials and Methods: Twenty-two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascular malformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma to be stained with Endothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody. Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (37.44±23.16) for lobular capillary hemangioma and (25.02±13.89) for hemangioma and (6.34±3.52) for lymphangioma. According to post hoc test ESM-1 marker expression showed a high significant difference between (hemangioma and lymphangioma=0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011) Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma.

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Capillary Hemangioma of the Foot

Journal of the American Podiatric Medical Association ◽

10.7547/87507315-92-3-155 ◽

2002 ◽

Vol 92 (3) ◽

pp. 155-157 ◽

Cited By ~ 2

Author(s):

Joseph A. Cione ◽

John Cozzarelli

Keyword(s):

Surgical Treatment ◽

Head And Neck ◽

Clinical Case ◽

Lower Extremities ◽

Neck Region ◽

Capillary Hemangioma ◽

Vascular Lesions ◽

Head And Neck Region ◽

Infancy And Childhood ◽

Mucous Membranes

Capillary hemangiomas are benign, vascular lesions of skin and mucous membranes that often occur in infancy and childhood. Capillary hemangiomas are most commonly found in the head and neck region. Capillary hemangiomas that occur in adults and on the lower extremities are uncommon. A clinical case involving surgical treatment of the lesion on an adult foot is presented. (J Am Podiatr Med Assoc 92(3): 155-157, 2002)

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Lobular Capillary Hemangioma of Head and Neck Region: A Retrospective Study in A Tertiary Centre

Scholarly Journal of Otolaryngology ◽

10.32474/sjo.2020.04.000194 ◽

2020 ◽

Vol 4 (4) ◽

Author(s):

Tulachan Bishow

Keyword(s):

Retrospective Study ◽

Head And Neck ◽

Neck Region ◽

Capillary Hemangioma ◽

Lobular Capillary Hemangioma ◽

Head And Neck Region ◽

Tertiary Centre

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Pyogenic Granuloma: A Case Report

Health Renaissance ◽

10.3126/hren.v8i3.4215 ◽

1970 ◽

Vol 8 (3) ◽

pp. 196-198 ◽

Cited By ~ 1

Author(s):

Md T Rizwanulla ◽

Bandana Koirala ◽

Shivalal Sharma ◽

Lalita Adhikari ◽

Anju Pradhan

Keyword(s):

Case Report ◽

Inflammatory Response ◽

Pyogenic Granuloma ◽

Capillary Hemangioma ◽

Definitive Diagnosis ◽

Vascular Lesions ◽

Minor Trauma ◽

Lobular Capillary Hemangioma ◽

Dental Restorations ◽

Foreign Materials

Anju Pradhan was added as an author of this paper on 04/03/2011Pyogenic granulomas (PG) are common benign vascular lesions of the skin and mucosa. They are neither infective, purulent nor granulomatous as the name might suggest-rather a reactive enlargement that is an inflammatory response to local irritation such as calculus, fractured tooth, minor trauma, rough dental restorations and foreign materials. Here, we report a case of 13 year old patient with PG and in addition to the knowledge, the importance of biopsy findings in establishing definitive diagnosis has been emphasized. Keywords: pyogenic granuloma; inflammatory hyperplasia; lobular capillary hemangioma. DOI: 10.3126/hren.v8i3.4215Health Renaissance, September-December 2010; Vol 8 (No.3);196-198

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Role of sclerotherapy in management of low flow vascular malformations

International Surgery Journal ◽

10.18203/2349-2902.isj20211303 ◽

2021 ◽

Vol 8 (4) ◽

pp. 1234

Author(s):

Manpreet Kaur ◽

Parul Sachdeva ◽

Rajan Syal ◽

Savijot Singh

Keyword(s):

Head And Neck ◽

Vascular Malformations ◽

Neck Region ◽

Low Flow ◽

Vascular Lesions ◽

Surgical Removal ◽

Complete Regression ◽

Head And Neck Region ◽

Life Threatening

Background: Low flow vascular malformations are most common in the head and neck region. Only symptomatic malformations require treatment. Sclerotherapy followed by surgery was considered the gold standard treatment but in the head and neck region, it may produce cosmetic and physiological defects. In the present study, multiple injections of sclerotherapy with 3% sodium tetradecyl sulphate was used for the treatment of low flow vascular malformations.Methods: Twenty cases of low flow vascular malformations of the oral cavity who presented in the outpatient department of ESIC Model Hospital, Ludhiana from 2014-2016 were selected for the study. Only significantly sized (>4 cm) and easily accessible lesions were included. Staged sequential sclerotherapy with 3% STS under strict fluoroscopy control was used as the sole treatment.Results: A total of 20 patients were taken of which, 25% required three sessions, 65% five to six sessions each and 10% required eight sessions each. All patients showed good results with complete regression and no mucosal ulceration.Conclusions: Staged sequential sclerotherapy with 3% STS should be the treatment of choice in low flow vascular lesions involving mucosal and cutaneous structures of head and neck region especially anterior two-thirds of tongue, palate, gingiva, buccal mucosa and lips. Surgical removal may affect critical neurovascular structures and cause cosmetic deformity. So the removal is advisable in life-threatening conditions, lesions requiring general anaesthesia and single sitting removal.

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