Evaluation of Phospholipase A2 Activity, High Sensitive C- Reactive Protein Level and White Blood Cell Count as Predictive Markers in Acute Appendicitis: Novel Approach

2021 ◽  
Vol 04 (03) ◽  
Author(s):  
Suma S ◽  
Sreeramulu PN ◽  
Dayanand CD
Keyword(s):  
Acute Appendicitis ◽  
Blood Cell ◽  
Phospholipase A2 ◽  
Cell Count ◽  
Protein Level ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein ◽  
Novel Approach ◽  
Phospholipase A2 Activity

Phospholipase A2, C-reactive protein, and white blood cell count in the diagnosis of acute appendicitis

1994 ◽  
Vol 40 (9) ◽  
pp. 1757-1760 ◽  
Author(s):  
J M Grönroos ◽  
J J Forsström ◽  
K Irjala ◽  
T J Nevalainen
Keyword(s):  
Acute Appendicitis ◽  
Blood Cell ◽  
Phospholipase A2 ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Predictive Value ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein

Abstract We compared the predictive value of determining group II phospholipase A2 (PLA2) in serum for diagnosing acute appendicitis with the predictive values of white blood cell count (WBC) and measurement of C-reactive protein (CRP). In this prospective study, we included 186 patients who were undergoing appendectomy after clinical diagnoses of acute appendicitis. The performance of each test was measured by receiver-operating characteristic curves. WBC was the test of choice in diagnosing uncomplicated acute appendicitis. However, in contrast to CRP and PLA2, which increased in patients with protracted inflammation, there was not a concomitant increase in WBC. Therefore, especially CRP, but also PLA2, were better indicators of appendiceal perforation or abscess formation than was WBC. Increased WBC, CRP, and PLA2 values did not unequivocally corroborate the clinical suspicion of appendicitis, but if all three values were within normal limits, acute appendicitis could be excluded with a 100% predictive value. PLA2 values showed a highly significant correlation with CRP but not with WBC values, which supports the view that PLA2 represents an acute-phase reactant.

scholarly journals Predictive values of Alvarado score, serum C-reactive protein, and white blood cell count in the diagnosis of acute appendicitis: a prospective study

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Ademola Olusegun Talabi ◽  
Tewogbade Adeoye Adedeji ◽  
Oludayo Adedapo Sowande ◽  
Olusanya Adejuyigbe
Keyword(s):  
Acute Appendicitis ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Alvarado Score ◽  
Reactive Protein ◽  
Wbc Count

Abstract Background The diagnosis of acute appendicitis in children is quite challenging as the rate of negative appendectomy varies between 15 and 57%. Increased utilization of imaging diagnostic facilities in advanced countries seems to have reduced the incidence of operating on normal appendix to a single digit. In low- and middle-income countries, the incidence remains unacceptably high (double digits). Inflammatory markers and scoring systems may be a suitable adjunct to increase diagnostic yield in most third world countries. Thus, the aim of this study was to evaluate the diagnostic value of Alvarado score, white blood cell count, and serum C-reactive protein in children with acute appendicitis. Results The ages of patients ranged between 4 and 15 years with a mean of 11.2 ± 2.8 years. The male to female ratio was 1.4 to 1.0. Nineteen percent of patients had negative appendiceal findings on histological examination. The sensitivity and specificity of Alvarado score, C-reactive protein estimation, total white blood cell count in diagnosing acute appendicitis were 86.4% and 63.2%, 98.8% and 36.8%, and 51.9% and 89.5% respectively. Alvarado score has the highest area under ROC curve analysis 0.824, 95% CI of 0.724 to 0.924 compared with CRP, 0.769. 95% CI of = 0.647 to 0.891 and WBC count, 0.765, 95% CI of 0.643 to 0.887. Both CRP and WBC count showed higher discriminatory values between complicated and uncomplicated appendicitis, p < 0.001. Conclusion Alvarado score outperformed other tests in setting the diagnosis of acute appendicitis. However, none of the tests can be relied on wholly for operative decision. Clinical judgement remains the bedrock for diagnosis and operative management.

Misinterpretation of C reactive protein level and white blood cell count are behind the overuse of antibiotics in acute pancreatitis

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S109
Author(s):  
Eszter Tóth ◽  
Tamás Lantos ◽  
Dóra Illés ◽  
Szilárd Gódi ◽  
Ákos Szűcs ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Protein Level ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein

Accuracy of White Blood Cell Count and C-reactive Protein Levels Related to Duration of Symptoms in Patients Suspected of Acute Appendicitis

2015 ◽  
Vol 22 (9) ◽  
pp. 1015-1024 ◽  
Author(s):  
Jasper J. Atema ◽  
Sarah L. Gans ◽  
Ludo F. Beenen ◽  
Boudewijn R. Toorenvliet ◽  
Helena Laurell ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Duration Of Symptoms ◽  
Protein Levels ◽  
Reactive Protein
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