Comparative efficacy and safety of intra-nasal dexmedetomidine and oral midazolam as pre medication in children undergoing minor elective surgical procedures: Results of a randomized, double blind trial

2019 ◽  
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Vikram Vardhan ◽  
Poonam Sangamlal Gupta ◽  
EK Ramdas ◽  
...  
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Karl Andersen ◽  
Myron H Weinberger ◽  
Brent Egan ◽  
Christian M Constance ◽  
Mohammed A Ali ◽  
...  

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M. Opadczuk ◽  
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...  

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pp. 73-77 ◽  
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O. Le Bon ◽  
M. Gavrilovic ◽  
K. Lion ◽  
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BackgroundAcamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions.MethodIn order to assess the efficacy and safety of the drug in the treatment of detoxified alcoholics, we performed a 90-day double-blind trial comparing two dosages of acamprosate (1332 mg/day and 1998 mg/day).ResultsFor all efficacy parameters, acamprosate appeared to be significantly superior to placebo, with a trend towards a better effect at the higher dosage. Furthermore, acamprosate appeared to be extremely safe.ConclusionThis study confirms that acamprosate could be an interesting adjuvant for maintaining abstinence in detoxified alcoholics.


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