INFLUENCE OF EPIDERMAL GROWTH FACTOR ON THE PROCESSES OF REGENERATION OF GRANULATION TISSUE IN THE POSTOPERATIVE CAVITY OF THE TEMPORAL BONE OBTAINED IN THE COURSE OF A CANAL WALL DOWN MASTOIDECTOMY

2018 ◽  
Vol 20 (1) ◽  
pp. 128-133
Author(s):  
S.Yu. Ognetov ◽  
◽  
N.A. Kiryanov ◽  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Temporal Bone ◽  
Granulation Tissue ◽  
Canal Wall ◽  
Epidermal Growth ◽  
Canal Wall Down ◽  
Canal Wall Down Mastoidectomy

scholarly journals The depth of the facial nerve in the mastoid bone

2018 ◽  
Vol 4 (3) ◽  
pp. 666
Author(s):  
B. Y. Praveen Kumar ◽  
K. T. Chandrashekhar ◽  
M. K. Veena Pani ◽  
Sunil K. C. ◽  
Anand Kumar S. ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Temporal Bone ◽  
Significant Variation ◽  
Canal Wall ◽  
Stylomastoid Foramen ◽  
Cortical Mastoidectomy ◽  
Canal Wall Down ◽  
Canal Wall Down Mastoidectomy ◽  
The Mean ◽  
Temporal Bones

<p class="abstract"><strong>Background:</strong> The hallmark of the temporal bone is variation. Various important structures like the facial nerve run in the temporal bone at various depths which can be injured during mastoidectomy.</p><p class="abstract"><strong>Methods:</strong> Twenty wet cadaveric temporal bones were dissected. A cortical mastoidectomy was performed followed by a canal wall down mastoidectomy and the depth of the vertical segment of the facial nerve in the mastoid was determined.  </p><p class="abstract"><strong>Results:</strong> The mean depth of the second genu was 13.82 mm. The mean depth of the stylomastoid foramen was 12.75 mm and the mean distance from the annulus at 6’0 clock to the stylomastoid foramen was 10.22 mm.</p><p><strong>Conclusions:</strong> There is significant variation in the average depth of the facial nerve in the mastoid. </p>

scholarly journals Repair of Temporal Bone Encephalocele following Canal Wall Down Mastoidectomy

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Sarantis Blioskas ◽  
Ioannis Magras ◽  
Stavros Polyzoidis ◽  
Konstantinos Kouskouras ◽  
Georgios Psillas ◽  
...  
Keyword(s):  
Temporal Bone ◽  
Chronic Otitis Media ◽  
Base Deficit ◽  
Layer By Layer ◽  
Canal Wall ◽  
Temporalis Fascia ◽  
Dural Graft ◽  
Canal Wall Down ◽  
Canal Wall Down Mastoidectomy

We report a rare case of a temporal bone encephalocele after a canal wall down mastoidectomy performed to treat chronic otitis media with cholesteatoma. The patient was treated successfully via an intracranial approach. An enhanced layer-by-layer repair of the encephalocele and skull base deficit was achieved from intradurally to extradurally, using temporalis fascia, nasal septum cartilage, and artificial dural graft. After a 22-month follow-up period the patient remains symptom free and no recurrence is noted.

scholarly journals Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone

Oncotarget ◽  
2015 ◽  
Vol 6 (13) ◽  
pp. 11357-11368 ◽  
Author(s):  
Shigeru Kawabata ◽  
M. Christine Hollander ◽  
Jeeva P. Munasinghe ◽  
Lauren R. Brinster ◽  
José R. Mercado-Matos ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Temporal Bone ◽  
Middle Ear ◽  
Growth Factor Receptor ◽  
Molecular Target ◽  
Epidermal Growth

scholarly journals Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes

1987 ◽  
Vol 247 (2) ◽  
pp. 385-388 ◽  
Author(s):  
M Laato ◽  
V M Kähäri ◽  
J Niinikoski ◽  
E Vuorio
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Granulation Tissue ◽  
Collagen Gene ◽  
Fibroblast Proliferation ◽  
Collagen Production ◽  
Collagen Gene Expression ◽  
Epidermal Growth ◽  
Stimulation Of

The effects of epidermal growth factor (EGF) on granulation-tissue formation and collagen-gene expression were studied in experimental sponge-induced granulomas in rats. After daily administration of 5 micrograms of EGF into the sponge, total RNA was extracted from the ingrown granulation tissue at days 4 and 7 and analysed by Northern hybridization for the contents of mRNAs for types I and III procollagens. EGF treatment increased procollagen mRNA, particularly at day 4. To determine whether this elevation was due to increased proliferation of collagen-producing fibroblasts or to activation of collagen-gene expression in these cells, fibroblast cultures were started from granulation tissue and treated with EGF. These experiments confirmed that EGF is a potent mitogen for granuloma fibroblasts in a dose-dependent manner. The effect of EGF treatment on radioactive hydroxyproline production in cultured cells was inhibitory. The decreased rate of collagen synthesis was also indicated by decreased amounts of procollagen mRNAs. The results suggest that the stimulation of wound healing and collagen production by EGF is due to increased fibroblast proliferation, and not to increased expression of type I and III procollagen genes.

Epidermal growth factor increases granulation tissue formation dose dependently

1987 ◽  
Vol 43 (4) ◽  
pp. 322-328 ◽  
Author(s):  
Anne Buckley ◽  
Jeffrey M. Davidson ◽  
Craig D. Kamerath ◽  
Stephen C. Woodward
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Granulation Tissue ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Epidermal Growth

Effect of epidermal growth factor (EGF) on experimental granulation tissue

1986 ◽  
Vol 41 (3) ◽  
pp. 252-255 ◽  
Author(s):  
Matti Laato ◽  
Juha Niinikoski ◽  
Claes Lundberg ◽  
Karl-E. Arfors
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Granulation Tissue ◽  
Epidermal Growth

External Auditory Canal Reconstruction and Mastoid Obliteration Using Modified Palva Flap in Canal Wall Down Mastoidectomy With Tympanoplasty

2019 ◽  
Vol 128 (6_suppl) ◽  
pp. 69S-75S
Author(s):  
Ji-Sun Kim ◽  
Il Gye Lim ◽  
Jeong-Hoon Oh ◽  
Byung Guk Kim ◽  
Ki-Hong Chang
Keyword(s):  
Temporal Bone ◽  
External Auditory Canal ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Canal Wall ◽  
Mastoid Obliteration ◽  
Before And After ◽  
The Status ◽  
Canal Wall Down ◽  
Canal Wall Down Mastoidectomy

Objective: To evaluate the effectiveness of a modified Palva flap used for external auditory canal reconstruction and mastoid obliteration in canal wall down mastoidectomy. Methods: We retrospectively analyzed patients who underwent canal wall down mastoidectomy with tympanoplasty using modified Palva flap. All patients underwent pure tone audiometry and temporal bone computed tomography (CT) before surgery, and the same tests were performed in the first year after surgery. The external auditory canal volumes were calculated by summing the areas of each section selected in temporal bone CT. For each patient, the ratio of external auditory canal volume was calculated from CT taken before and after surgery. Results: The mean of external auditory canal volume after canal wall down with a modified Palva flap was about 1.4 times larger than before surgery. The modified Palva flap is effective for the reconstruction of the external auditory canal. Both pure tone audiometry level and air-bone gap showed statistically significant improvement after surgery ( Ps = .001 and .002, respectively). Conclusions: The external auditory canal volume slightly increased, but the status of mastoid obliteration was well maintained 1 year after surgery. The modified Palva flap used in this study is an easy and effective method in external auditory canal reconstruction and mastoid obliteration.

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