Prediction of drug-drug interaction relating to the induction of drug metabolizing enzymes

2014 ◽  
Vol 29 (5) ◽  
pp. 417-425
Author(s):  
Shuya Yoshida ◽  
Fumiyoshi Yamashita
Keyword(s):  
Drug Interaction ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Drug Drug Interaction

In vitro characterization of drug metabolizing enzymes and transporters to enable a mechanistic drug-drug interaction assessment for venetoclax

2017 ◽  
Vol 32 (1) ◽  
pp. S51 ◽  
Author(s):  
Ryota Kikuchi ◽  
Mohamad Shebley ◽  
Daniel A.J. Bow ◽  
Robert A. Carr ◽  
Marjoleen Nijsen ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
In Vitro Characterization ◽  
Drug Drug Interaction

In Vitro Assessment of Drug-Drug Interaction Potential of Boceprevir Associated with Drug Metabolizing Enzymes and Transporters

2013 ◽  
Vol 41 (3) ◽  
pp. 668-681 ◽  
Author(s):  
Xiaoyan Chu ◽  
Xiaoxin Cai ◽  
Donghui Cui ◽  
Cuyue Tang ◽  
Anima Ghosal ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
In Vitro Assessment ◽  
Drug Drug Interaction

Herb-Drug Interactions and Hepatotoxicity

2019 ◽  
Vol 20 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Mohammad K. Parvez ◽  
Vikas Rishi
Keyword(s):  
Drug Interaction ◽  
Drug Interactions ◽  
Viral Hepatitis ◽  
Prescription Drugs ◽  
Herbal Remedies ◽  
Public Health Issue ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Pharmaceutical Industries ◽  
Underlying Mechanisms

Background: In recent times, herbals or phytomedicines have become very popular due to their global acceptance as a complementary and alternative remedy. While modern drugs are commercially available only after laboratory validations, clinical trials, as well as approval from drug regulatory authorities, majority of the marketed herbal products lack such scientific evidence of efficacy and safety. This results in herb or herb-drug interaction induced unfavorable clinical outcomes without crucial documentation on their temporal relations and concomitant use. Methods: An online literature search for peer-reviewed articles was conducted on the PubMed, Europe PMC, Medline and Google Scholar portals, using the phrases: complementary & alternative medicine, traditional Chinese medicine, herb-drug interaction, mechanisms of herb-drug interaction, herb-induced toxicity, herbal hepatotoxicity and causality, traditional medicine, viral hepatitis, etc. Results: The retrieved data showed that globally, patients are attracted to herbal remedies with the misconception that these are completely safe and therefore, use them simultaneously with prescription drugs. Notably, there exists a potential risk of herb-drug interactions leading to some adverse side effects, including hepatotoxicity. The toxicological effect of a drug or herb is due to the inhibition of drug metabolizing enzymes (e.g., cytochrome P450), including interactions with certain prescription drugs through various mechanisms. Several cases of hepatotoxicity due to use of herbals in viral hepatitis-related liver diseases have been recently reported. However, limited experimental data and clinical evidence on herbal pharmacokinetics hamper the evaluation and reporting of adverse reactions and the underlying mechanisms. Conclusion: Herb-drug interaction related morbidity is thus an emerging serious public health issue with broad implications for clinicians, pharmaceutical industries and health authorities. Nonetheless, despite increasing recognition of herb-drug interaction, a standard system for interaction prediction and evaluation is still nonexistent. This review article discusses the herb-drug interactions related hepatotoxicity and underlying mechanisms, including drug metabolizing enzymes and their regulation.

scholarly journals Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Shi Sun ◽  
Yifang Wang ◽  
Ailing Wu ◽  
Zhen Ding ◽  
Xinguang Liu
Keyword(s):  
Drug Interaction ◽  
Clinical Practice ◽  
Influence Factors ◽  
Herbal Medicines ◽  
The Body ◽  
Drug Metabolizing Enzymes ◽  
The West ◽  
Metabolizing Enzymes ◽  
Potential Factors ◽  
Clinical Risks

Herbal medicines have been used to prevent and cure diseases in eastern countries for thousands of years. In recent decades, these phytotherapies are becoming more and more popular in the West. As being nature-derived is the essential attribute of herbal medicines, people believe that taking them for diseases treatment is safe enough and has no side-effects. However, the efficacy of herbal resourced compounds (HRC) depends on the multiple constituents absorbed in the body and their pharmacokinetics. Thus, many factors will influence the clinical practice of HRC, i.e., their absorption, distribution, metabolism, and excretion (ADME). Among these factors, herb-drug interaction has been widely discussed, as these compounds may share the same drug-metabolizing enzymes and drug transporters. Meanwhile there are many other potential factors that can also change the ADME of HRC, including herb pretreatment, herb-herb interactions, pathological status, gender, age of patient, and chemical and physical modification of certain ingredients. With the aim of ensuring the efficacy of HRC and minimizing their clinical risks, this review provides and discusses the influence factors and artificial improvement of the pharmacokinetics of HRC.

Sign in / Sign up

Export Citation Format

Share Document