On the Road to Improved Performance

The capacity of a road section depends on many factors, such as the width of the carriageway, the permissible visibility, the slopes, the turning radii, the composition of the cars, the maneuverability and the design of the cars. The development of the automotive industry leads to improved performance of cars and improved throughput. Changing all of these components changes the bandwidth. When the capacity is calculating the composition of the traffic flow became one of the key factors. Mobile traffic is characterized by the composition of different (by age and purpose) vehicles. The composition of the traffic flow is displayed as a percentage. Obtaining and analyzing the algorithm for determining the capacity of traffic flow on a particular section of road (interchange). The analyze of the current state of car use in Ukraine and select the optimal algorithm for obtaining real flow data on the road section was made. The main task of the engineer during the design of a certain section of the road is to ensure the maximum capacity of the road section. Maximum throughput is achieved by improving the road surface, widening the roadway (increasing the number of lanes and installing appropriate signs), allocating reversing lanes and installing reversing traffic lights. When calculating the capacity, it is necessary to take into account when characterizing the relationship between cars in the flow in different road conditions. Intervals between cars in a stream can change even at high intensity of movement that in turn quit

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On the Road to Accurate Protein Biomarkers in Prostate Cancer Diagnosis and Prognosis: Current Status and Future Advances

International Journal of Molecular Sciences ◽

10.3390/ijms222413537 ◽

2021 ◽

Vol 22 (24) ◽

pp. 13537

Author(s):

Yiwu Yan ◽

Su Yeon Yeon ◽

Chen Qian ◽

Sungyong You ◽

Wei Yang

Keyword(s):

Prostate Cancer ◽

High Sensitivity ◽

Molecular Biomarkers ◽

Current Status ◽

Protein Biomarkers ◽

The Road ◽

Diagnosis And Prognosis ◽

Clinicopathologic Parameters ◽

Improved Performance ◽

On The Road

Prostate cancer (PC) is a leading cause of morbidity and mortality among men worldwide. Molecular biomarkers work in conjunction with existing clinicopathologic tools to help physicians decide who to biopsy, re-biopsy, treat, or re-treat. The past decade has witnessed the commercialization of multiple PC protein biomarkers with improved performance, remarkable progress in proteomic technologies for global discovery and targeted validation of novel protein biomarkers from clinical specimens, and the emergence of novel, promising PC protein biomarkers. In this review, we summarize these advances and discuss the challenges and potential solutions for identifying and validating clinically useful protein biomarkers in PC diagnosis and prognosis. The identification of multi-protein biomarkers with high sensitivity and specificity, as well as their integration with clinicopathologic parameters, imaging, and other molecular biomarkers, bodes well for optimal personalized management of PC patients.

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