The Promising Role of TGF- β/SMAD4 in Pancreatic Cancer: The future targeted therapy

Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attractive in clinical immunotherapy and targeted therapy for cancer patients. In addition, TEXs as biomarkers have important clinical diagnostic and prognostic value. Recently, TEXs have been recognized to play important roles in the abscopal effect (AbE), a newly discovered mechanism by which the distant tumors are effectively targeted and repressed during immunotherapy and radiotherapy. Therefore, TEXs has demonstrated great clinical potential in the diagnosis, prognosis and treatment of cancer patients in the future. This review summarizes and discusses the role of TEXs in clinical therapy and their role in AbE in recent studies.

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Role of radiotherapy in combination with chemotherapy, targeted therapy, and immunotherapy in the management of pancreatic cancer

Journal of Radiation Oncology ◽

10.1007/s13566-013-0125-4 ◽

2013 ◽

Vol 2 (4) ◽

pp. 369-379 ◽

Cited By ~ 2

Author(s):

Andrew Sharabi ◽

Joseph Herman ◽

Vivian Weiss ◽

Daniel Laheru ◽

Richard Tuli

Keyword(s):

Pancreatic Cancer ◽

Targeted Therapy

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The Role of Precision Medicine in Pancreatic Cancer: Challenges for Targeted Therapy, Immune Modulating Treatment, Early Detection, and Less Invasive Operations

Cancer Translational Medicine ◽

10.4103/2395-3977.181434 ◽

2016 ◽

Vol 2 (2) ◽

pp. 41 ◽

Cited By ~ 3

Author(s):

Yi Le ◽

KhaledKyle Wong ◽

Zhirong Qian

Keyword(s):

Pancreatic Cancer ◽

Targeted Therapy ◽

Early Detection ◽

Precision Medicine ◽

Less Invasive

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The Role of Nuclear Factor κB in Pancreatic Cancer and the Clinical Applications of Targeted Therapy

Pancreas ◽

10.1097/mpa.0b013e31815b3207 ◽

2008 ◽

Vol 36 (3) ◽

pp. 225-235 ◽

Cited By ~ 64

Author(s):

Bryan Holcomb ◽

Michele Yip-Schneider ◽

C. Max Schmidt

Keyword(s):

Pancreatic Cancer ◽

Targeted Therapy ◽

Nuclear Factor Κb ◽

Clinical Applications ◽

Nuclear Factor

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Challenges of Fear Conditioning Research in the Age of RDoC

Zeitschrift für Psychologie ◽

10.1027/2151-2604/a000303 ◽

2017 ◽

Vol 225 (3) ◽

pp. 189-199 ◽

Cited By ~ 5

Author(s):

Tina B. Lonsdorf ◽

Jan Richter

Keyword(s):

Fear Conditioning ◽

Clinical Diagnosis ◽

Research Domain Criteria ◽

Major Focus ◽

The Future ◽

Definition Of ◽

Methodological Considerations ◽

Research Domain

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.

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