scholarly journals The Promising Role of TGF- β/SMAD4 in Pancreatic Cancer: The future targeted therapy

2019 ◽  
Vol 3 (2) ◽  
pp. 1-7
Author(s):  
Sunjida Ahmed ◽  
Christopher Schwartz ◽  
M Dewan ◽  
Ruliang Xu
2015 ◽  
Vol 26 ◽  
pp. vi97
Author(s):  
D. Ciliberto ◽  
N. Staropoli ◽  
S. Chiellino ◽  
T. Del Giudice ◽  
F. Caglioti ◽  
...  

2007 ◽  
Vol 6 (10) ◽  
pp. 672-674
Author(s):  
Pieter H.M. De Mulder ◽  
Timothy Eisen ◽  
Jean-Jaques Patard ◽  
Cezary Szczylik ◽  
Thomas Otto ◽  
...  

Life ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 381
Author(s):  
Zechen Shan ◽  
Hongmei Wang ◽  
Yujuan Zhang ◽  
Weiping Min

Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attractive in clinical immunotherapy and targeted therapy for cancer patients. In addition, TEXs as biomarkers have important clinical diagnostic and prognostic value. Recently, TEXs have been recognized to play important roles in the abscopal effect (AbE), a newly discovered mechanism by which the distant tumors are effectively targeted and repressed during immunotherapy and radiotherapy. Therefore, TEXs has demonstrated great clinical potential in the diagnosis, prognosis and treatment of cancer patients in the future. This review summarizes and discusses the role of TEXs in clinical therapy and their role in AbE in recent studies.


2013 ◽  
Vol 2 (4) ◽  
pp. 369-379 ◽  
Author(s):  
Andrew Sharabi ◽  
Joseph Herman ◽  
Vivian Weiss ◽  
Daniel Laheru ◽  
Richard Tuli

Pancreas ◽  
2008 ◽  
Vol 36 (3) ◽  
pp. 225-235 ◽  
Author(s):  
Bryan Holcomb ◽  
Michele Yip-Schneider ◽  
C. Max Schmidt

2017 ◽  
Vol 225 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Tina B. Lonsdorf ◽  
Jan Richter

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.


2011 ◽  
Author(s):  
Daniel Bartels ◽  
Oleg Urminsky ◽  
Shane Frederick
Keyword(s):  

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