Comparative evaluation of various methods of experimental modeling of neuropathic pain syndrome in rats

2021 ◽  
pp. 27-34
Author(s):  
N.V. Aleksandrovskaya ◽  
A.A. Kruglova
Keyword(s):  
Neuropathic Pain ◽  
Comparative Evaluation ◽  
Pain Syndrome ◽  
Experimental Modeling ◽  
Neuropathic Pain Syndrome

First experience with chronic epidural spinal cord stimulation in Khanty-Mansi autonomous okrug — clinical observations

2021 ◽  
Vol LIII (2) ◽  
pp. 94-100
Author(s):  
Olga A. Bondarenko ◽  
Gaspar V. Gavrilov ◽  
Vadim A. Padurets ◽  
Roman V. Kasich
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Chronic Neuropathic Pain ◽  
Neuropathic Pain Syndrome ◽  
Epidural Stimulation ◽  
Cord Injury ◽  
Epidural Spinal Cord Stimulation ◽  
And Migration

Purpose of the work. The article is devoted to the first experience of epidural stimulation in the Khanty-Mansiysk Autonomous Okrug at the budgetary institution Surgut Clinical Trauma Hospital. Clinical examples are presented for two main indications for the application of this technique (disease of the operated spine, a consequence of spinal cord injury in combination with chronic neuropathic pain syndrome). Research methods. An assessment of the intensity of pain syndrome was given according to a visual analogue scale, the Pain Detect questionnaire; indicators of anxiety, depression on the HADS scale; quality of life according to the Oswestry questionnaire for a follow-up period of 6-12 months in patients with chronic epidural stimulation. Results. A positive assessment of the action during test neurostimulation was 63.3% (38 patients). Of the established permanent systems, a good result was achieved and persisted for 12 months or more in 96% (24 patients). It was necessary to change the stimulation parameters in 13% (3 patients). Revision of permanent systems was performed in 20% (5 patients), due to the progression of the degenerative-dystrophic process of the spine, damage and migration of system elements. Conclusions. Chronic epidural spinal cord stimulation has established itself as a personalized, highly effective, minimally invasive and safe method of treating chronic neuropathic pain syndromes. Multicomponent corrective action is of scientific interest and requires further study.

Response of Chronic Neuropathic Pain Syndrome to Ketamine

1994 ◽  
Vol 38 (5) ◽  
pp. 285
Author(s):  
MIROSLAV BACKONJA ◽  
GEORGE ARNDT ◽  
KATHY A COMBAR ◽  
BILL CHECK ◽  
MARRY ZIMMERMAN
Keyword(s):  
Neuropathic Pain ◽  
Pain Syndrome ◽  
Chronic Neuropathic Pain ◽  
Neuropathic Pain Syndrome

Neuro-microglial interactions in the spinal centers of pain modulation in the neuropathic pain syndrome

2017 ◽  
Vol 11 (2) ◽  
pp. 161-167 ◽  
Author(s):  
I. V. Manzhulo ◽  
O. S. Ogurtsova ◽  
A. A. Tyrtyshnaia ◽  
I. V. Dyuizen
Keyword(s):  
Neuropathic Pain ◽  
Pain Syndrome ◽  
Pain Modulation ◽  
Neuropathic Pain Syndrome

scholarly journals Complex Therapy of Acute Poisoning by Thallium Compounds (Literature review and data from own research)

2020 ◽  
Vol 89 (2) ◽  
pp. 32-39
Author(s):  
G.M. Balan ◽  
A.G. Bogomol ◽  
O.P. Kravchuk ◽  
P.G. Zhminko ◽  
A.H. Kudriavtseva
Keyword(s):  
Neuropathic Pain ◽  
Literature Review ◽  
Liver Damage ◽  
Pain Syndrome ◽  
Acute Poisoning ◽  
Neuropathic Pain Syndrome ◽  
Complex Therapy ◽  
Toxic Liver Damage ◽  
Thallium Compounds ◽  
High Doses

The Aim of the Research. Based on the analysis of modern literature data and our own research to substantiate the principles of rational complex therapy with acute poisoning by thallium compounds (Tl+) at different stages of intoxication. Materials and Methods. The analysis of literature data and our own researches is carried out and the principles of rational complex therapy with acute poisoning by thallium compounds at different stages of intoxication development are substantiated and the algorithm of doctors’ actions at suspicion of acute Tl+ poisoning is defined. Results and Conclusions. The principles of complex therapy of acute Tl+ poisonings substantiated, which includes antidote therapy, methods of extracorporeal treatment (plasmapheresis, hemosorption, hemodialysis), treatment of toxic encephalopolyradiculoneuropathy, neuropathic pain syndrome and toxic liver damage. The sequence of appearance of the main symptoms of intoxication at low and high doses of Tl+ is determined, which allows to assume poisoning by this toxicant. Key Words: thallium, acute poisoning, complex therapy.

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