scholarly journals Comparison of magnesium sulphate as an adjuvant to lignocaine with lignocaine alone in intravenous regional anaesthesia for upper limb surgery in improving tourniquet pain.

2020 ◽  
Vol 27 (06) ◽  
pp. 1311-1315
Author(s):  
Syed Mehmood Ali ◽  
Sadaf Bokhari ◽  
Hajra Shuja
Keyword(s):  
Magnesium Sulfate ◽  
Upper Limb ◽  
Magnesium Sulphate ◽  
Regional Anaesthesia ◽  
Control Group ◽  
Analgesic Requirement ◽  
Tourniquet Pain ◽  
Upper Limb Surgery ◽  
Intravenous Regional Anaesthesia ◽  
Mean Time

Objectives: To compare mean time to the first analgesic requirement with the Magnesium sulfate with lignocaine and lignocaine alone under intravenous regional anaesthesia for upper limb surgery. Study Design: Randomized Controlled Trial. Setting: Operative Rooms of Shaikh Zayed Hospital, Lahore. Period: October 2, 2018 to April 2, 2019. Material & Methods: For the analysis, a total of 150 (75 subjects per group) were selected that fulfilled the inclusion criteria. Those subjects were allocated by the use of the tables to two separate anesthetic regimes. Lignocaine plus magnesium sulphate was given to experimental group (M) as an adjunct and control group (L) was given simple IVRA with lignocaine. Mean Atrial Pressure, Heart Rate, and SpO2 were tracked every 2 minutes after start of anesthesia before and after use of the tourniquet. All the patients will be counseled to report if they experience tourniquet pain. When patients complained of tourniquet pain it was assessed on VAS of l-10 and patient was given analgesia if pain >3 on VAS. The data were collected and analyzed in SPSS v25.0. The median time for analgesics was used in both groups for the analysis of the independent t-test. A p-value of 0.05 was estimated significant. Results: 150 patients were enrolled. Mean time to first analgesic requirement is greater with the Magnesium sulfate with lignocaine and lignocaine alone in patients undergoing upper limb surgery under intravenous regional anaesthesia 51.9±4.2 minutes vs. 32.1±4.4 minutes (p=0.000). Conclusion: The findings indicate that the tourniquet pain is reduced by adding magnesium sulphate as an adjuvant to lignocaine.

scholarly journals Evaluation of the Efficacy of Magnesium Sulphate as an Adjuvant to Lignocaine for Intravenous Regional Anaesthesia for Upper Limb Surgery

2008 ◽  
Vol 36 (6) ◽  
pp. 840-844 ◽  
Author(s):  
S. Narang ◽  
J. S. Dali ◽  
M. Agarwal ◽  
R. Garg
Keyword(s):  
Upper Limb ◽  
Normal Saline ◽  
Magnesium Sulphate ◽  
Regional Anaesthesia ◽  
Motor Block ◽  
Sensory Block ◽  
Tourniquet Pain ◽  
Upper Limb Surgery ◽  
Significant Difference ◽  
Intravenous Regional Anaesthesia

Several additives have been combined with local anaesthetics for intravenous regional anaesthesia to improve block quality, analgesia and to decrease tourniquet pain. Magnesium sulphate is one potential additive. This prospective, randomised, double-blinded study was conducted in 30 ASA physical status I or II patients undergoing upper limb surgery under tourniquet. In group L, patients received intravenous regional anaesthesia with lignocaine alone (9 ml of 2% lignocaine diluted with normal saline to total volume of 36 ml). Patients in group M received intravenous regional anaesthesia with lignocaine plus magnesium sulphate (6 ml of 25% magnesium sulphate plus 9 ml of 2% lignocaine diluted with normal saline to total volume of 36 ml). Assessment was by observing the response to injection of drug; sensory and motor block and tourniquet pain. The mean time of onset of sensory block was 12.40 and 3.47 minutes in groups L and M respectively (P <0.001). The average times of onset of motor block in groups L and M were 17 and six minutes respectively (P <0.001). Of the patients in group M, 66.7% reported moderate to severe pain while the drug was being injected, compared to 20% in group L (P=0.011). There was a statistically significant difference in visual analogue scale for tourniquet pain at 10 and 30 minutes after tourniquet inflation (lower in group M). These findings indicate that magnesium sulphate added as an adjuvant to lignocaine hastens the onset of sensory and motor block and decreases tourniquet pain. However, there is increased incidence of transient pain on injection if magnesium sulphate is added.

Comparison of Tramadol and Butorphanol as Adjuncts to Lignocaine for Intravenous Regional Anaesthesia for Upper Limb Surgeries

2017 ◽  
Vol 4 (4 (Part-2)) ◽  
pp. 1110-1114
Author(s):  
Kaur Jasleen ◽  
◽  
Jagdev Jagjit Singh ◽  
Kirti Rishi ◽  
Sachin Arora ◽  
...  
Keyword(s):  
Upper Limb ◽  
Regional Anaesthesia ◽  
Intravenous Regional Anaesthesia

scholarly journals The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

2021 ◽  
Vol 31 (2) ◽  
Author(s):  
Fatemeh Jahanian ◽  
Iraj Goli Khatir ◽  
Hamed Amini Ahidashti ◽  
Sepideh Amirifard
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Magnesium Sulfate ◽  
Magnesium Sulphate ◽  
Intervention Group ◽  
Control Group ◽  
Double Blind ◽  
Intravenous Magnesium ◽  
Acute Exacerbations ◽  
And Control

BACKGROUND፡ Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are serious complications that often require immediate intervention in an emergency department (ED). The aim of this study was to investigate the effect of intravenous magnesium sulphate as an adjuvant in the treatment of AECOPD in the ED.METHODS: In a double-blind, randomized clinical trial, a total of 60 patients with AECOPD presenting to the ED of Imam Khomeini Hospital in Sari, Iran, were included. The study was conducted between September 2016 and February 2018. Eligible patients were randomly allocated into two groups of intervention and control. Patients in the intervention and control groups received intravenous infusion of magnesium sulfate (2 gr) or normal saline over 30 minutes, respectively. For all patients, Borgdyspnea score, forced expiratory volume in one second (FEV1) result and clinical variables of interest were evaluated before the beginning of the intervention, and also 45 minutes and 6 hours after the commencement of intervention.RESULTS: Regardless of time of evaluation, pulse rate (PR), respiratory rate (RR) and Borg score in intervention group was lower than control group. Also, FEV1 and SPO2 were greater in intervention group compared to control group. However, these differences were not statistically significant (between-subject differences or group effect) (p<0.001). The trends of FEV1, SPO2, PR, RR and Borg score were similar between two groups of study (no interaction effect; P>0.05).CONCLUSION: According to the results of this study, it seems that using intravenous magnesium sulfate has no significant effect on SPO2, FEV1, RR, and PR of patients with AECOPD who presented to ED.

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