Development Of Analytical Method For The Simultaneous Estimation Of Diclofenac Sodium And Pantoprazole In Pharmaceutical Formulation By RP-HPLC

2020 ◽  
Vol 10 (1) ◽  
pp. p9718
Author(s):  
S.S. Ajmire ◽  
L.R. Gandhi ◽  
Anil Dewani ◽  
Ravi Bakal ◽  
A.V. Chandewar
Keyword(s):  
Analytical Method ◽  
Diclofenac Sodium ◽  
Pharmaceutical Formulation ◽  
Simultaneous Estimation ◽  
Rp Hplc

Stability Indicating Assay Method Development and Validation of Simultaneous Estimation of Chlorzoxazone, Diclofenac Sodium and Paracetamol in Bulk Drug and Tablet by RP-HPLC

2021 ◽  
pp. 5024-5028
Author(s):  
Krutika Patel ◽  
Sudheer Kumar Verriboina ◽  
S.G. Vasantharaju
Keyword(s):  
Method Development ◽  
Diclofenac Sodium ◽  
Potassium Dihydrogen Phosphate ◽  
Hplc Method ◽  
Assay Method ◽  
Simultaneous Estimation ◽  
Dihydrogen Phosphate ◽  
Stability Indicating ◽  
Rp Hplc ◽  
Bulk Drug

A simple, accurate, specific and stability-indicating RP-HPLC method was developed for simultaneous determination of chlorzoxazone, diclofenac sodium and paracetamol, using C18 Vydac Monomeric 120A (250 × 4.6mm, 5μ) at 40ºC. The mobile phase contains a mixture of 20mM potassium dihydrogen phosphate buffer (pH 6.2 adjusted with potassium hydroxide) and acetonitrile (30:70 v/v). The flow rate was 1ml/min and detection was carried out at 275nm using PDA detector. The retention time of paracetamol, chlorzoxazone and diclofenac sodium were 3.28mins, 13.27mins and 15.61mins respectively. The analytical curve was linear over a concentration range of 0.65- 6.5μg/ml for paracetamol, 1-10μg/ml for chlorzoxazone and 0.1-1μg/ml for diclofenac sodium. The drugs in bulk and tablet were subjected to acid and alkali hydrolysis, oxidation, thermal and photolytic degradation. This method can be successfully employed for simultaneous quantitative analysis of Chlorzoxazone, Diclofenac sodium and Paracetamol in bulk drug and tablet formulation.

scholarly journals Development and validation of simultaneous estimation of drugs in combination from pharmaceutical formulation by RP-HPLC method

2020 ◽  
Vol 12 (3) ◽  
pp. 155-165
Author(s):  
Pooja Eknathji Waware ◽  
Anuja Dattatriayji Jolhe ◽  
Swati Rajendra Lilhare ◽  
Prasad Prakash Jumade ◽  
Dharmendra Ramgopalji Mundhada
Keyword(s):  
Hplc Method ◽  
Pharmaceutical Formulation ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Development And Validation
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