scholarly journals The effect of tamoxifen on the electrochemical behavior of Bi+3/Bi on the glassy carbon electrode and its determination via differential pulse anodic stripping voltammetry

2019 ◽  
Vol 63 (1) ◽  
Author(s):  
Mehdi Jalali ◽  
Zeinab Deris Falahieh ◽  
Mohammad Alimoradi ◽  
Jalal Albadi ◽  
Ali Niazi

The electrochemical behavior of Bi+3 ions on the surface of a glassy carbon electrode, in acidic media and in the presence of tamoxifen, was investigated. Cyclic voltammetry, chronoamperometry, differential pulse voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy were used to find the probable mechanism contributing to the reduction of the peak height of bismuth oxidation with an increase in the concentration of tamoxifen. The obtained results show a slight interaction between the bismuth species and tamoxifen which co-deposit on the surface of glassy carbon electrode. Therefore, the reduction in the peak height of bismuth oxidation as a function of tamoxifen concentration was used to develop a new differential pulse anodic striping voltammetry method for determination of trace amount of tamoxifen. The effects of experimental parameters on the in situ DPASV of Bi+3 ions in the presence of tamoxifen shown the optimal conditions as: 2 mol L-1 H2SO4 (1% v v-1 MeOH), a deposition potential of -0.5 V, a deposition time of 60 s, and a glassy carbon electrode rotation rate of 300 rpm. The calibration curve was plotted in the range of 0.5 to 6 µg mL-1 and the limits of detection and quantitation were calculated to be 3.1 × 10-5 µg mL-1 and 1.0 × 10-4 µg mL-1, respectively. The mean, RSD, and relative bias for 0.5 µg mL-1 (n=5) were found to be 0.49 µg mL-1, 0.3%, and 2%, respectively. Finally, the proposed method was successfully used for the determination of tamoxifen in serum and pharmaceutical samples.

2018 ◽  
Vol 10 (24) ◽  
pp. 2917-2923 ◽  
Author(s):  
Zorica Stojanović ◽  
Zuzana Koudelkova ◽  
Eliska Sedlackova ◽  
David Hynek ◽  
Lukas Richtera ◽  
...  

In this work, differential pulse anodic stripping voltammetry (DP-ASV) for the determination of trace amounts of hexavalent chromium (Cr(vi)) at a silver plated glassy carbon electrode (Ag plated-GCE) is described in detail.


2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Daniel Apath ◽  
Mambo Moyo ◽  
Munyaradzi Shumba

In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully.


2004 ◽  
Vol 144 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Mohamed S. Ibrahim ◽  
Yassien M. Temerk ◽  
Moustafa M. Kamal ◽  
Gamal A.-W. Ahmed ◽  
Hossieny S. M. Ibrahim

2009 ◽  
Vol 20 (9) ◽  
pp. 1698-1704 ◽  
Author(s):  
Augusto César de Andrade Lima ◽  
Emanuella Gomes da Silva ◽  
Marília Oliveira Fonseca Goulart ◽  
Josealdo Tonholo ◽  
Tiago Terto da Silva ◽  
...  

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