Laboratory and clinical parameters of sows at the prevention of inflammatory processes in the reproductive organs

2019 ◽  
Vol 22 (3) ◽  
pp. 38-43
Author(s):  
Y.N. Brigadirov ◽  
◽  
V.N. Kotsarev ◽  
I.T. Shaposhnikov ◽  
G.G. Chusova ◽  
...  
Author(s):  
Yu.N. Brigadirov ◽  
◽  
V.N. Kotsarev ◽  
G.G. Chusova ◽  
A.E. Lobanov ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
pp. 052-058
Author(s):  
Vanessa Helena Pires Diniz ◽  
Arthur Diniz Vial ◽  
Raquel Tolentino Dornelas Alves

Pain control remains an urgent task. If the goal is to achieve permanent pain relief and not temporarily mask the pain (masking the pathology), then that goal can only be achieved by treating the pain with physiotherapeutic methods, the most universal and effective of them is low-level laser therapy intensity (LLLT). Treatment methods vary fundamentally in the case of neuropathic pain (nonspecific, primary), which includes pain with trigger point (PT) and nociceptive (specific, secondary) pain, which includes all types of pain resulting from trauma, inflammation, etc. When treating patients with fibromyalgia (FM), which is a chronic condition with high worldwide prevalence, auxiliary therapies have been indicated for the treatment of fibromyalgia including low-level laser. Currently, the low intensity laser has been attached to a bracelet over the radial artery, in order to irradiate blood cells, using a technique called modified ILIB (Intravascular Laser Irradiation of Blood), with improved control of fibromyalgia, of chronic inflammatory processes. This study evaluated the effectiveness of the modified ILIB in improving the clinical parameters of fibromyalgia used to treat a patient who had chronic pain for 20 years, who received conventional treatment associated with two laser applications using the modified ILIB technique.


Author(s):  
Karthikeyan Subbarayan ◽  
Kamatchi Ulagappan ◽  
Claudia Wickenhauser ◽  
Barbara Seliger

The recent COVID-19 outbreak in China led to a worldwide pandemic associated with a severe acute respiratory illness. A higher incidence of COVID-19 infection was demonstrated in cancer patients, including patients with lung cancer. This study was conducted to get insights into the reasons for this enhanced frequency of COVID-19 infection. Methods: Using different bioinformatic tools, the expression and methylation pattern of ACE2 and TMPRSS2 gene were analyzed in healthy and malignant tissues with a focus on lung adenocarcinoma (LUAD) and correlated to clinical parameters and smoking history. Results: ACE2 and TMPRSS2 were heterogeneously expressed across 36 healthy tissues with the highest expression in digestive, urinary and reproductive organs, while their expression was significantly lower in 36 cancer tissues. In LUAD, ACE2, but not TMPRSS2 was overexpressed, which inversely correlated to the promoter methylation. An age-dependent upregulation of ACE2 expression was found in LUAD compared to normal lung tissues. In a healthy lung, TMPRSS2 expression was dependent on sex and smoking history and downregulated in LUAD of smokers. Cancer progression was associated with decreased TMPRSS2, but unaltered ACE2 expression, while ACE2 expression in lung metastases of different cancers was higher than in metastasis of other sites. TMPRSS2, but not ACE2 expression, was associated with LUAD patients’ survival. Conclusions: Comprehensive molecular analyses revealed a heterogeneous, distinct expression and methylation profile of ACE2 and TMPRSS2 in healthy lung vs LUAD tissues across sex, age and smoking history, which is associated with clinical parameters and might have implications for COVID-19 disease.


2020 ◽  
pp. 7-14
Author(s):  
N.M. Hychka ◽  
◽  
O.A. Shcherba ◽  
L.D. Lastovetska ◽  
◽  
...  

Inflammatory diseases of the pelvic organs (PID) occupy the first place in the structure of gynecological morbidity and are one of the causes of dysfunction of not only the reproductive organs but also various systems of the female body, infertility, and a decrease in the quality of life. The PID includes inflammatory processes of the uterus, fallopian tubes, ovaries and pelvic peritoneum. The article presents modern views on etiological factors, stages of development of endogenous infection and its clinical manifestations. The mechanisms of endocrine and immune regulation of the vaginal microbiocenosis, as well as the relationship of endogenous microflora and pathogens of exogenous genital infections, are examined. Diagnostic approaches and principles of treatment of PID are presented, taking into account the severity of the infectious process. Key words: рelvic inflammatory diseases, salpingitis, endometritis, microbiocenosis, sexual exinfection, diagnosis, treatment principles.


2020 ◽  
Vol 2 (11) ◽  
pp. 96-102
Author(s):  
Brigadirov Yu. N. ◽  
◽  
Kotsarev V. N. ◽  
Chusova G. G. ◽  
Lobanov A. E. ◽  
...  

2019 ◽  
Vol 2 ◽  
pp. 91-99
Author(s):  
Iu. N. Brigadirov ◽  
◽  
V. N. Kotsarev ◽  
I. T. Shaposhnikov ◽  
O. A. Manzhurina ◽  
...  

Author(s):  
Karthikeyan Subbarayan ◽  
Kamatchi Ulagappan ◽  
Claudia Wickenhauser ◽  
Barbara Seliger

The recent COVID-19 outbreak in China led to a worldwide pandemic associated with a severe acute respiratory illness. A higher incidence of COVID-19 infection was demonstrated in cancer patients, including patients with lung cancer. This study was conducted to get insights into the reasons for this enhanced frequency of COVID-19 infection. Methods: Using different bioinformatic tools, the expression and methylation pattern of ACE2 and TMPRSS2 gene were analyzed in healthy and malignant tissues with a focus on lung adenocarcinoma (LUAD) and correlated to clinical parameters and smoking history. Results: ACE2 and TMPRSS2 were heterogeneously expressed across 36 healthy tissues with the highest expression in digestive, urinary and reproductive organs, while their expression was significantly lower in 36 cancer tissues. In LUAD, ACE2, but not TMPRSS2 was overexpressed, which inversely correlated to the promoter methylation. An age-dependent upregulation of ACE2 expression was found in LUAD compared to normal lung tissues. In a healthy lung, TMPRSS2 expression was dependent on sex and smoking history and downregulated in LUAD of smokers. Cancer progression was associated with decreased TMPRSS2, but unaltered ACE2 expression, while ACE2 expression in lung metastases of different cancers was higher than in metastasis of other sites. TMPRSS2, but not ACE2 expression, was associated with LUAD patients’ survival. Conclusions: Comprehensive molecular analyses revealed a heterogeneous, distinct expression and methylation profile of ACE2 and TMPRSS2 in healthy lung vs LUAD tissues across sex, age and smoking history, which is associated with clinical parameters and might have implications for COVID-19 disease.


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