scholarly journals ANTIHYPERGLYCEMIC ACTIVITY OF Alphonsea Sclerocarpa Thw. IN STZ-INDUCED DIABETIC RATS

2021 ◽  
Vol 10 (9) ◽  
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Activity

Chenopodium quinoa Exhibits Antihyperglycemic Activity in Streptozotocin-Induced Diabetic Rats

2021 ◽  
Vol 19 ◽  
Author(s):  
Amine Azzane ◽  
Ayou Amssayef ◽  
Mohame Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Histopathological Examination ◽  
Chenopodium Quinoa ◽  
Diabetic Rats ◽  
Favorable Effect ◽  
Antihyperglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aims: The aim of the study was to evaluate the antihyperglycemic effect of Chenopodium quinoa. Background: Chenopodium quinoa is a pseudocereal plant with several medicinal properties. Objective: The goal of this investigation was to determine the antihyperglycemic activity of Chenopodium quinoa in both normal and streptozotocin(STZ)-induced diabetic rats. Methods: In this study, the effect of the aqueous extract of Chenopodium quinoa seeds (AECQS) (60 mg/kg) on blood glucose levels was evaluated in both normal and diabetic rats after a single (6 hours) and repeated oral administration (7 days of treatment). The effect of this herb on glucose tolerance and lipid profile was also studied. Additionally, histopathological examination of liver was carried out using the Hematoxylin-Eosin method. Furthermore, the in vitro antioxidant activity as well as a preliminary phytochemical screening and quantification of some secondary metabolites (phenolic compounds, flavonoids and tannins) were performed according to standard methods. Results: AECQS produced a significant lowering effect on plasma glucose levels in STZ-induced diabetic rats. In addition, this extract exhibited a remarkable amelioration on hepatic histopathology in diabetic rats. In addition, the extract exerted a remarkable antioxidant activity which could be due to the presence of some compounds found in this herb. Conclusion: In conclusion, this study demonstrates that the aqueous extract of Chenopodium quinoa seeds has a favorable effect in controlling diabetes mellitus.

scholarly journals Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats

2011 ◽  
Vol 2 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Sudipta Das ◽  
Sanjib Bhattacharya ◽  
Angelene Prasanna ◽  
R. B. Suresh Kumar ◽  
Goutam Pramanik ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Activity ◽  
Preclinical Evaluation

scholarly journals Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Sriparna KunduSen ◽  
Pallab K. Haldar ◽  
Malaya Gupta ◽  
Upal K. Mazumder ◽  
Prerona Saha ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Biochemical Parameters ◽  
Diabetic Rats ◽  
Serum Biochemical Parameters ◽  
Fruit Peel ◽  
Antihyperglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Serum Biochemical ◽  
Citrus Limetta

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg-1 body weight daily for 15 days. Glibenclamide (0.5 mg kg-1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P<0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.

Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats

2011 ◽  
Vol 138 (3) ◽  
pp. 769-773 ◽  
Author(s):  
Sagar Naskar ◽  
Upal K. Mazumder ◽  
Goutam Pramanik ◽  
Malaya Gupta ◽  
R.B. Suresh Kumar ◽  
...  
Keyword(s):  
Cocos Nucifera ◽  
Diabetic Rats ◽  
Antihyperglycemic Activity ◽  
Type 2 Diabetic

scholarly journals Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats

2017 ◽  
Vol 55 (2) ◽  
pp. 269-272 ◽  
Author(s):  
Essam Abdel-Sattar ◽  
Shohda A. EL-Maraghy ◽  
Riham Salah El-Dine ◽  
Sherine M. Rizk
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Activity

scholarly journals Ethanolic Extract ofButea monospermaLeaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Mehdi Bin Samad ◽  
Ashraf Ul Kabir ◽  
Ninadh Malrina D'Costa ◽  
Farjana Akhter ◽  
Arif Ahmed ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Hepatic Glycogen ◽  
Antihyperglycemic Activity ◽  
Isolated Rat Islets ◽  
Type 2 Diabetic ◽  
Glycogen Formation ◽  
Isolated Rat

We measured a vast range of parameters, in an attempt to further elucidate previously claimed antihyperglycemic activity ofButea monosperma. Our study clearly negates the possibility of antidiabetic activity by inhibited gastrointestinal enzyme action or by reduced glucose absorption. Reduction of fasting and postprandial glucose level was reconfirmed (P<0.05). Improved serum lipid profile via reduced low density lipoprotein (LDL), cholesterol, triglycerides (TG), and increased high density lipoprotein (HDL) was also reestablished (P<0.05). Significant insulin secretagogue activity ofB. monospermawas found in serum insulin assay ofB. monospermatreated type 2 diabetic rats (P<0.01). This was further ascertained by our study on insulin secretion on isolated rat islets (P<0.05). Improved sensitivity of glucose was shown by the significant increase in hepatic glycogen deposition (P<0.05). Hence, we concluded that antihyperglycemic activity ofB. monospermawas mediated by enhanced insulin secretion and enhanced glycogen formation in the liver.

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