scholarly journals Arcuate Fasciculus Lateralization is Not A Marker of Language Lateralization in Children with Intractable Epilepsy

2019 ◽  
Vol 2 (10) ◽  
pp. 02-10
Author(s):  
Byron Bernal ◽  
Alfredo Ardila ◽  
Monica Rosselli ◽  
Michael Duchowny ◽  
Magno R Guillen ◽  
...  
Keyword(s):  
Intractable Epilepsy ◽  
Arcuate Fasciculus ◽  
Language Lateralization

Reorganization of the Right Arcuate Fasciculus Following Left Arcuate Fasciculus Resection in Children With Intractable Epilepsy

2011 ◽  
Vol 26 (10) ◽  
pp. 1246-1251 ◽  
Author(s):  
Dhruman Goradia ◽  
Harry T. Chugani ◽  
Rajkumar Munian Govindan ◽  
Michael Behen ◽  
Csaba Juhász ◽  
...  
Keyword(s):  
Intractable Epilepsy ◽  
Arcuate Fasciculus ◽  
The Right

scholarly journals Pathology type does not predict language lateralization in children with medically intractable epilepsy

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1498-1504 ◽  
Author(s):  
Darren S. Kadis ◽  
Elizabeth N. Kerr ◽  
James T. Rutka ◽  
O. Carter Snead III ◽  
Shelly K. Weiss ◽  
...  
Keyword(s):  
Intractable Epilepsy ◽  
Language Lateralization

scholarly journals Presurgical language lateralization assessment by fMRI and dichotic listening of pediatric patients with intractable epilepsy

2015 ◽  
Vol 7 ◽  
pp. 230-239 ◽  
Author(s):  
Fritjof Norrelgen ◽  
Anders Lilja ◽  
Martin Ingvar ◽  
Per Åmark ◽  
Peter Fransson
Keyword(s):  
Dichotic Listening ◽  
Pediatric Patients ◽  
Intractable Epilepsy ◽  
Language Lateralization

scholarly journals Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy

2019 ◽  
Vol 23 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Virendra R. Desai ◽  
Aditya Vedantam ◽  
Sandi K. Lam ◽  
Lucia Mirea ◽  
Stephen T. Foldes ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Pediatric Population ◽  
Intractable Epilepsy ◽  
Resting State Fmri ◽  
Hemispheric Dominance ◽  
Pediatric Epilepsy ◽  
Language Lateralization ◽  
The Right ◽  
And Task

OBJECTIVEDetermining language laterality in patients with intractable epilepsy is important in operative planning. Wada testing is the gold standard, but it has a risk of stroke. Both Wada and task-based functional MRI (tb-fMRI) require patient cooperation. Recently, resting-state fMRI (rs-fMRI) has been explored for language lateralization. In the present study, the correlation between rs-fMRI and tb-fMRI in language lateralization is estimated in a pediatric population with intractable epilepsy.METHODSrs-fMRI and tb-fMRI language lateralization testing performed as part of epilepsy surgery evaluation was retrospectively reviewed.RESULTSTwenty-nine patients underwent rs-fMRI and tb-fMRI; a total of 38 rs-fMRI studies and 30 tb-fMRI studies were obtained. tb-fMRI suggested left dominance in 25 of 30 cases (83%), right in 3 (10%), and in 2 (7%) the studies were nondiagnostic. In rs-fMRI, 26 of 38 studies (68%) suggested left dominance, 3 (8%) right dominance, 6 (16%) bilateral, and 3 (8%) were nondiagnostic. When tb-fMRI lateralized to the left hemisphere (25 cases), rs-fMRI was lateralized to the left in 23 patients (92%) and it was bilateral/equal in 2 (8%). When tb-fMRI lateralized to the right (3 cases), rs-fMRI lateralized to the right in all cases (100%). The overall concordance rate was 0.93 (95% CI 0.76–0.99) when considering cases with tb-fMRI and rs-fMRI performed within 6 months of each other, and tb-fMRI results were not nondiagnostic.CONCLUSIONSrs-fMRI significantly correlated with tb-fMRI in lateralizing language and suggests the potential role for identifying hemispheric dominance via rs-fMRI. Further investigation and validation studies are warranted.

scholarly journals Tractography of the arcuate fasciculus in healthy right-handed and left-handed multilingual subjects and its relation to language lateralization on functional MRI

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sandrine Yazbek ◽  
Stephanie Hage ◽  
Iyad Mallak ◽  
Tarek Smayra
Keyword(s):  
Functional Mri ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Arcuate Fasciculus ◽  
Fiber Volume ◽  
Language Lateralization ◽  
Highly Educated ◽  
Laterality Index ◽  
Left Handed ◽  
The Right

AbstractFunctional MRI (fMRI) enables evaluation of language cortical organization and plays a central role in surgical planning. Diffusion Tensor Imaging (DTI) or Tractography, allows evaluation of the white matter fibers involved in language. Unlike fMRI, DTI does not rely on the patient’s cooperation. In monolinguals, there is a significant correlation between the lateralization of language on fMRI and on DTI. Our objective is to delineate the arcuate fasciculus (AF) in right- and left-handed trilinguals and determine if the AF laterality on DTI is correlated to language lateralization on fMRI. 15 right and 15 left-handed trilingual volunteers underwent fMRI and DTI. Laterality Index was determined on fMRI (fMRI-LI). Mean Diffusivity, Fractional Anisotropy (FA), Number of Fibers, Fiber Length, Fiber Volume and Laterality Index (DTI-LI) of the AF were calculated on DTI. 28 of the 30 subjects presented a bilateral AF. Most subjects (52%) were found to have a bilateral language lateralization of the AF on DTI. Only 4 subjects had bilateral lateralization of language on fMRI. The right AF demonstrated lower diffusivity than the left AF in the total participants, the right-handed, and the left-handed subjects. FA, Volume and Length of the AF were not significantly different between the two hemispheres. No correlation was found between the DTI-LI of the AF and the fMRI-LI. A prominent role of the right AF and a bilateral structural organization of the AF was present in our multilingual population regardless of their handedness. While in prior studies DTI was able to determine language lateralization in monolingual subjects, this was not possible in trilingual highly educated subjects.

scholarly journals A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference

2010 ◽  
Vol 73 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Ruth E. Propper ◽  
Lauren J. O’Donnell ◽  
Stephen Whalen ◽  
Yanmei Tie ◽  
Isaiah H. Norton ◽  
...  
Keyword(s):  
Hand Preference ◽  
Functional Language ◽  
Arcuate Fasciculus ◽  
Language Lateralization

scholarly journals Tractography of the Arcuate Fasciculus in Healthy Right-Handed and Left-Handed Multilingual Subjects and Its Relation to Language Lateralization on Functional MRI

2021 ◽  
Author(s):  
Sandrine Yazbek ◽  
Stephanie Hage ◽  
Iyad Mallak ◽  
Tarek Smayra
Keyword(s):  
Functional Mri ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Arcuate Fasciculus ◽  
Fiber Volume ◽  
Language Lateralization ◽  
Highly Educated ◽  
Laterality Index ◽  
Left Handed ◽  
The Right

Abstract Purpose Functional MRI (fMRI) enables evaluation of language cortical organization and plays a central role in surgical planning. Diffusion Tensor Imaging (DTI) or Tractography, allows evaluation of the white matter fibers involved in language. Unlike fMRI, DTI does not rely on the patient's cooperation. In monolinguals, there is a good correlation between the lateralization of language on fMRI and on DTI. Our objective is to delineate the arcuate fasciculus (AF) in right- and left-handed trilinguals and determine if the AF laterality on DTI is correlated to language lateralization on fMRI.Methods 15 right and 15 left-handed trilingual volunteers underwent fMRI and DTI. Laterality Index was determined on fMRI (fMRI-LI). Mean Diffusivity, Fractional Anisotropy (FA), Number of Fibers, Fiber Length, Fiber Volume and Laterality Index (DTI-LI) of the AF were calculated on DTI.Results 28 of the 30 subjects presented a bilateral AF. Most subjects (52%) were found to have a bilateral language lateralization of the AF on DTI. Only 4 subjects had bilateral lateralization of language on fMRI. The right AF demonstrated lower diffusivity than the left AF in the total participants, the right-handed, and the left-handed subjects. FA, Volume and Length of the AF were not significantly different between the two hemispheres. No correlation was found between the DTI-LI of the AF and the fMRI-LI.Conclusion A prominent role of the right AF and a bilateral structural organization of the AF was present in our multilingual population regardless of their handedness. While in prior studies DTI was able to determine language lateralization in monolingual subjects, this was not possible in trilingual highly educated subjects.

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