Human Chorionic Gonadotropin in Abnormal Pregnancy. Serum and Urinary Findings Using Various Immunoassay Techniques

A 35-year-old woman presented to the emergency room for the evaluation of failed surgical and medical management of a suspected ectopic pregnancy. When imaging studies were performed, she had lymphadenopathy and diffuse sclerosis of the osseous framework. Multiple biopsies were performed and revealed poorly differentiated metastatic carcinoma with signet ring features. Esophagogastroduodenoscopy confirmed the findings of a Stage IV gastric adenocarcinoma. Signs and symptoms of gastric carcinoma are vague. However, to our knowledge, an elevation in human chorionic gonadotropin (hCG) is not an associated finding. Persistence of hCG has many causes from abnormal pregnancy to menopause and other forms of cancer.

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Gestational trophoblastic disease

Oxford Textbook of Obstetrics and Gynaecology ◽

10.1093/med/9780198766360.003.0066 ◽

2020 ◽

pp. 809-816

Author(s):

Hextan Y.S. Ngan ◽

Karen K.L. Chan ◽

Siew-Fei Ngu

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Elevated Serum ◽

Normal Pregnancy ◽

Gestational Trophoblastic Disease ◽

Good Prognosis ◽

Abnormal Pregnancy ◽

Trophoblastic Disease ◽

Neoplastic Lesion ◽

Placental Site

Gestational trophoblastic disease (GTD) arises from an abnormal pregnancy which can subsequently develop into a neoplastic lesion and cancer. The most common abnormal pregnancy preceding GTD is usually benign. Molar pregnancy histologically is classified into partial and complete mole. The malignant histological types include choriocarcinoma, placental site trophoblastic tumour, and epithelioid trophoblastic tumour. The presence of abnormal proliferating trophoblastic tissues can be detected by serum human chorionic gonadotropin assays. Hence, a disease entity without histology but characterized by a persistently elevated serum human chorionic gonadotropin concentration after molar or normal pregnancy is named gestational trophoblastic neoplasia and forms part of the GTD spectrum where treatment is required. Treatment of the malignant form of GTD is mostly by chemotherapy with good prognosis.

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Pregnancy-associated protein-A does not improve predictability of pregnancy success or failure over human chorionic gonadotropin levels in early normal and abnormal pregnancy**This paper is the opinion of the authors’ and does not represent the opinion of the Department of the Navy, Department of the Army or Department of Defense.††Supported in part by Commander Naval Medical Command Clinical Investigation Program, Washington, D.C.

Fertility and Sterility ◽

10.1016/s0015-0282(16)53052-0 ◽

1989 ◽

Vol 52 (5) ◽

pp. 854-857 ◽

Cited By ~ 6

Author(s):

Charles C. Coddington ◽

Michael J. Sinosich ◽

Edward G. Boston ◽

John J. Bartko ◽

Gary D. Hodgen

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Department Of Defense ◽

Clinical Investigation ◽

Protein A ◽

Abnormal Pregnancy ◽

Navy Department ◽

Department Of The Navy ◽

Department Of The Army

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Abstract #917: Injection of Human Chorionic Gonadotropin (HCG) Can Cause the Luteinized Unruptured Follicle Syndrome

Endocrine Practice ◽

10.1016/s1530-891x(20)42797-1 ◽

2015 ◽

Vol 21 ◽

pp. 186

Author(s):

Jerome Check ◽

Danyne Senft ◽

Michael Dougherty

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Luteinized Unruptured Follicle Syndrome ◽

Luteinized Unruptured Follicle

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Prurified anti-trophoblast antibodies (ATAB) suppress the secretion of human Chorionic Gonadotropin (hCG) and stimulate that of Plaminogen-Activator-Inhibitor Type 1 (PAI-1) in JEG-3 cells in vitro

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0036-1592760 ◽

2016 ◽

Vol 76 (10) ◽

Author(s):

Y Ye ◽

M Vogel ◽

P Burger ◽

N Rogenhofer ◽

S Mahner ◽

...

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Inhibitor Type ◽

Activator Inhibitor Type ◽

Activator Inhibitor ◽

Pai 1

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Human Chorionic Gonadotropin and CA 15-3 Producing Adenocarcinoma

Nuklearmedizin ◽

10.1055/s-0038-1632352 ◽

1998 ◽

Vol 37 (08) ◽

pp. 297-298 ◽

Cited By ~ 1

Author(s):

A. Özet ◽

A. Arpaci ◽

S. Kömiircü ◽

G. Üçkaya

Keyword(s):

Lung Adenocarcinoma ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Carbohydrate Antigen ◽

Beta Subunit ◽

Cancer Antigen ◽

First Report ◽

Primary Lung Adenocarcinoma ◽

Adenocarcinoma Of Lung

Summary50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.

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