Cortisol Suppression Index in Major Depressive Illness

1984 ◽  
Vol 18 (3) ◽  
pp. 277-279 ◽  
Author(s):  
Allen Fraser
Keyword(s):  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Diagnostic Confidence ◽  
Major Depressive ◽  
Acceptable Alternative ◽  
Late Evening ◽  
Suppression Test ◽  
Cortisol Suppression ◽  
Dexamethasone Suppression ◽  
Suppression Index

This study compares the utility of a cortisol suppression index with the standard dexamethasone suppression test as a diagnostic aid for major depressive disorder. In 50 patients the cortisol suppression index was found to have similar sensitivity while also having greater specificity and diagnostic confidence than the dexamethasone suppression test. By avoiding the need for a late-evening blood sample, the cortisol suppression index may be an acceptable alternative to the current procedure.

Performance of the Dexamethasone Suppression Test in Depressive Illness According to ICD and DSM-III Classification Systems

1988 ◽  
Vol 152 (4) ◽  
pp. 554-558 ◽  
Author(s):  
Sarah Watkins ◽  
Brian Harris ◽  
Nigel Cook ◽  
Roger Thomas ◽  
Diana Riad-Fahmy
Keyword(s):  
Major Depressive Episode ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Classification Systems ◽  
Manic Depressive Illness ◽  
Major Depressive ◽  
Diagnostic Categories ◽  
Manic Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression

The performance of the dexamethasone suppression test was assessed in 90 consecutive admissions with a diagnosis of depression, categorised according to two classification systems (DSM-III and ICD-9). Non-suppression was found in most of the diagnostic categories, but there was a highly significant association with the DSM-III classification ‘major depressive episode with melancholia’ (52%) in comparison with the ICD group ‘manic-depressive illness-depressed’ (29%).

Depression, Weight Loss and the Dexamethasone Suppression Test

1984 ◽  
Vol 145 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Alec Coppen ◽  
Janet Harwood ◽  
Keith Wood
Keyword(s):  
Weight Loss ◽  
Major Depressive Disorder ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Necessary Condition ◽  
Major Depressive ◽  
Significant Difference ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was carried out on 143 patients with a major depressive disorder, who were classified into those with a history of weight loss (n = 89) and those without (n = 54). Seventy-three per cent of patients with weight loss and 61% of patients without had an abnormal DST; this difference was not statistically significant. Of the patients receiving prophylactic lithium therapy, 13 were found to have changed their DST status on retesting after a period of 14 months, but there was no significant difference in their weight. It is concluded that weight loss is not a necessary condition for an abnormal DST in depressive illness.

The Dexamethasone Suppression Test in Depression

1987 ◽  
Vol 150 (4) ◽  
pp. 459-462 ◽  
Author(s):  
Alec Coppen ◽  
Maryse Metcalfe
Keyword(s):  
Collaborative Study ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
World Health ◽  
Major Depressive ◽  
Suppression Test ◽  
Health Organization ◽  
Almost All ◽  
Research Centres ◽  
Dexamethasone Suppression

The response to the dexamethasone suppression test (DST) was examined in 543 patients suffering from major depressive illness and 246 healthy controls, from 13 research centres, representing 12 different countries, in a World Health Organization Collaborative Study. In almost all the centres, the post-dexamethasone plasma Cortisol concentration was significantly higher in the patients than in the controls. Although there is variation between centres, this abnormal response to the DST was shown to be frequent in patients from widely different geographical areas.

Major Depressive Episode and Low Dose Dexamethasone Suppression Test

1982 ◽  
Vol 36 (2) ◽  
pp. 109-114
Author(s):  
Masakazu Sarai ◽  
Norio Taniguchi ◽  
Takao Kagomoto ◽  
Hideaki Kameda ◽  
Takeshi Uema ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Low Dose ◽  
Major Depressive Episode ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression

The Role of Stress in Interpreting the Dexamethasone Suppression Test

1992 ◽  
Vol 37 (10) ◽  
pp. 724-727 ◽  
Author(s):  
Jane Blouin ◽  
Eric Spindler ◽  
Edgardo Perez ◽  
Arthur Blouin ◽  
Steven Hotz ◽  
...  
Keyword(s):  
Environmental Stress ◽  
Psychological Assessment ◽  
Confounding Factor ◽  
Dexamethasone Suppression Test ◽  
Blood Tests ◽  
Routine Administration ◽  
Suppression Test ◽  
Cortisol Suppression ◽  
Dexamethasone Suppression

Stress has been implicated as a major confounding factor in the interpretation of Dexamethasone Suppression Test (DST) results. This study was designed to examine the effects of stress on DST results. Fifty patients with high levels of acute, chronic, and environmental stress participated in the study. Each patient was given a comprehensive psychiatric and psychological assessment, a routine administration of dexamethasone, and blood tests of cortisol values. The results indicate that the three measures of stress do not appear to affect levels of cortisol suppression, however, all three measures of stress predicted depression. As expected, DST cortisol levels were related to depression. Results are discussed in terms of their implications for understanding the associations among stress, depression and DST results.

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