Renal Transplantation in the Rat IV. Cortical Pressure Gradients Measured in Vivo and during Isolated Perfusion with Reference to Renal Function after Transplantation

1975 ◽  
Vol 35 (5) ◽  
pp. 463-472 ◽  
Author(s):  
L. Frödin ◽  
A. Engberg ◽  
Ö. Källskog ◽  
M. Wolgast
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Pressure Gradients ◽  
Isolated Perfusion

Early measurement of interstitial fibrosis predicts long-term renal function and graft survival in renal transplantation

1996 ◽  
Vol 83 (8) ◽  
pp. 1082-1085 ◽  
Author(s):  
M. L. Nicholson ◽  
T. A. McCulloch ◽  
S. J. Harper ◽  
T. J. Wheatley ◽  
C. M. Edwards ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Graft Survival ◽  
Interstitial Fibrosis ◽  
Early Measurement

Renal circulatory occlusion and local cooling

1959 ◽  
Vol 14 (2) ◽  
pp. 227-232 ◽  
Author(s):  
S. Birkeland ◽  
A. Vogt ◽  
J. Krog ◽  
C. Semb
Keyword(s):  
Renal Function ◽  
Body Temperature ◽  
Renal Artery ◽  
Clinical Application ◽  
Renal Ischemia ◽  
Local Cooling ◽  
Experimental Procedure ◽  
Reversible Lesion ◽  
Initial Depression

A method was developed for local kidney cooling in vivo, evaluated in dogs and applied clinically. In dogs a reversible lesion was not obtained if renal ischemia lasted beyond 1 hour at 37℃. Application of local cooling (10±5℃) extended the tolerance time to 7 hours, with clamping of the entire renal pedicle, and to 12 hours with occlusion of the renal artery alone. Exposure of the same kidney to a second occlusion period (up to 9 hr.) resulted in a reversible lesion. Renal function studies (CU, CIn, CPAH and TmPAH) showed the same pattern (initial depression and course of recovery) as after renal ischemia at body temperature. Initial depression was roughly paralleling the duration of clamping. Preischemic function values were, in most instances, reached 3 months following the experimental procedure. Physiological aspects of ‘local cooling’ are discussed and the advantages over general hypothermia are pointed out. The technique used for clinical application is described. Submitted on April 25, 1958

Effects of endothelin-1 on renal function and renin secretion in vivo and in vitro

1990 ◽  
Vol 183 (5) ◽  
pp. 1814-1815
Author(s):  
S. Morimoto ◽  
K. Hisaki ◽  
K. Nakase ◽  
R. Ikegawa ◽  
K. Hayashi ◽  
...  
Keyword(s):  
Renal Function ◽  
Renin Secretion ◽  
Endothelin 1

Longterm renal function protection in renal transplantation by nonimmunological treatments

1997 ◽  
pp. 167-174
Author(s):  
François Berthoux ◽  
Salem El Deeb ◽  
Eric Alamartine ◽  
Jean-Pierre De Filippis ◽  
Nabil Diab
Keyword(s):  
Renal Function ◽  
Renal Transplantation

Long-Term Outcomes of Renal Function After Adult Intestinal Transplantation at a Single Small-Volume Center: 2 Cases of Renal Transplantation

2019 ◽  
Vol 51 (5) ◽  
pp. 1525-1530
Author(s):  
Kyung Jai Ko ◽  
Hye Kyung Chang ◽  
Su-Kyung Kwon ◽  
Young Hwa Kim ◽  
Mi-Hyeong Kim ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Small Volume ◽  
Intestinal Transplantation ◽  
Long Term Outcomes

Renal effects induced by prolonged mPGES1 inhibition

2014 ◽  
Vol 306 (1) ◽  
pp. F68-F74 ◽  
Author(s):  
Francisco Salazar ◽  
Michael L. Vazquez ◽  
Jaime L. Masferrer ◽  
Gabriel Mbalaviele ◽  
Maria T. Llinas ◽  
...  
Keyword(s):  
Renal Function ◽  
Plasma Renin ◽  
In Vivo Studies ◽  
Renal Effects ◽  
Excretory Function ◽  
Membrane Bound ◽  
Inflammatory Drugs ◽  
Chronically Instrumented Dogs

The importance of membrane-bound PGE synthase 1 (mPGES1) in the regulation of renal function has been examined in mPGES1-deficient mice or by evaluating changes in its expression. However, it is unknown whether prolonged mPGES1 inhibition induces significant changes of renal function when Na+ intake is normal or low. This study examined the renal effects elicited by a selective mPGES1 inhibitor (PF-458) during 7 days in conscious chronically instrumented dogs with normal Na+ intake (NSI) or low Na+ intake (LSI). Results obtained in both in vitro and in vivo studies have strongly suggested that PF-458 is a selective mPGES1 inhibitor. The administration of 2.4 mg·kg−1·day−1 PF-458 to dogs with LSI did not induce significant changes in renal blood flow (RBF) and glomerular filtration rate (GFR). A larger dose of PF-458 (9.6 mg·kg−1·day−1) reduced RBF ( P < 0.05) but not GFR in dogs with LSI and did not induce changes of renal hemodynamic in dogs with NSI. Both doses of PF-458 elicited a decrease ( P < 0.05) in PGE2 and an increase ( P < 0.05) in 6-keto-PGF1α. The administration of PF-458 did not induce significant changes in renal excretory function, plasma renin activity, and plasma aldosterone and thromboxane B2 concentrations in dogs with LSI or NSI. The results obtained suggest that mPGES1 is involved in the regulation of RBF when Na+ intake is low and that the renal effects elicited by mPGES1 inhibition are modulated by a compensatory increment in PGI2. These results may have some therapeutical implications since it has been shown that prolonged mPGES1 inhibition has lower renal effects than those elicited by nonsteroidal anti-inflammatory drugs or selective cyclooxygenase-2 inhibitors.

scholarly journals Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series

2019 ◽  
Vol 41 (4) ◽  
pp. 534-538 ◽  
Author(s):  
Guilherme Palhares Aversa Santos ◽  
Luis Gustavo Modelli de Andrade ◽  
Mariana Farina Valiatti ◽  
Mariana Moraes Contti ◽  
Hong Si Nga ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Renal Transplantation ◽  
Case Series ◽  
Kidney Injury ◽  
Organ Donors ◽  
Retrospective Case ◽  
Proportional Increase ◽  
Deceased Donors

ABSTRACT Introduction: The number of incident and prevalent patients on dialysis has increased, as well as the number of candidates for renal transplantation in Brazil, without a proportional increase in the number of organ donors. The use of expanded kidneys, as to renal function, may be an alternative to increase the supply of organs. Objective: to discuss the feasibility of using expanded kidneys for renal function, which are in severe acute renal injury. Methods: All cases of renal transplantation of deceased donors performed at the Hospital das Clínicas de Botucatu of UNESP, from January 2010 to June 2018, totaling 732 cases were evaluated. Cases with final donor creatinine greater than 6 mg/dL were selected. Results: four patients were selected, of whom all donors were in severe acute kidney injury (AKI). These donors presented rhabdomyolysis as a probable cause of severe AKI, were young, with no comorbidities and had decreased urinary volume in the last 24 hours. The clinical evolution of all the recipients was satisfactory, with a glomerular filtration rate after transplantation ranging from 48 to 98 mL/min/1.73 m2. Conclusion: this series of cases shows the possibility of using renal donors in severe AKI, provided the following are respected: donor age, rhabdomyolysis as the cause of AKI, and implantation-favorable biopsy findings. Additional studies with better designs, larger numbers of patients and longer follow-up times are needed.

P1644SAPS AND EPTS SCORES AS PREDICTORS OF RENAL FUNCTION IN RECENT RENAL TRANSPLANTATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jimmy Reinaldo Sanchez Gil ◽  
Armando Coca ◽  
Guadalupe Rodriguez Portela ◽  
Carmen Aller Aparicio ◽  
Alicia Mendiluce
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Serum Creatinine ◽  
Roc Curve ◽  
Graft Function ◽  
Risk Scores ◽  
Critical Care Units ◽  
Saps Ii ◽  
Combined Use ◽  
The Us

Abstract Background and Aims The risk scores used in Critical Care Units estimate the severity and mortality of patients. The SAPS (Simplified Acute Physiologic Score) and its SAPS II and SAPS III variants calculate the severity by collecting the values recorded in the first 24 hours. The EPTS (Estimated Post-Transplant-Survival) is used as a reference for the allocation of organs in the US by the OPTN. The objective is to determine its use in recent renal transplant units as estimator of subsequent renal function, in services where patients move from the operating room to a nephrological intermediate care unit. Method The SAPS (II and III) and OPTN scores were applied in 87 (N = 87) consecutive renal transplanted patients. The point value of each of the scales was evaluated with the creatinine values at hospital discharge, and one month after the transplant. The scores obtained on the SAPS scales were divided as follows (SAPSIIA &lt;20 points, SAPSIIB ≥20 points) (SAPSIII A &lt;30 points, SAPSIIIB ≥30 points). In the EPTS scale, two cut-off points were used to divide the groups (20% Score; EPTS-IA ≤20%, EPTS-IB&gt; 20%), (Score 40%; EPTS-IIA ≤40%, EPTS -IIB&gt; 40). The sérum creatinine means of each of the groups were compared. Data were analyzed with SPSS 20.0.0 Results Significant differences were found in serum creatinine levels in renal function at the first month of transplantation in the SAPS II groups (SAPS IIA 1.38 mg / dl, SAPS IIB 1.79 mg / dl; P = 0.017 95% CI). With an area under the ROC curve of 0.65 (P = 0.017 95% CI). In the SAPS III groups no significant differences were found. In the EPTS scales, there were also significant differences in creatinine one month after the transplant in the group with a score of 40% (EPTS-IIA ≤40% 1.42 mg / dl, EPTS-IIB&gt; 40 1.81 mg / dl; P = 0.024 95% CI) With an Area under the ROC curve of 0.64 (P = 0.037 95% CI). Conclusion The SAPSII and EPTS scores can be a useful tool in estimating renal function one month after renal transplantation, giving a prognosis of renal graft function. The combined use of these scales together with other functional graft tests could have an important relevance in the management and follow-up of recent renal transplantation. Other studies with larger sample sizes are necessary to establish the appropriate cut-off points for the scales.

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