Reversible lesion of the corpus callosum associated with COVID-19: A case report

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system and peripheral nervous system. Major central nervous system manifestations of SARS-CoV-2 infection include seizures, meningoencephalitis, ischemic stroke, anosmia, and hypogeusia. The reversible splenial lesion syndrome was first described in 2004. Although reversible splenial lesion syndrome was initially recognized as a benign phenomenon, a second type of reversible splenial lesion syndrome was identified in later years, which has a poorer prognosis and potentially serious sequela. Reversible splenial lesion syndrome can be caused by numerous etiologies including viruses. In this report, we present a rare case of COVID-19 with reversible splenial lesion, who presented with ataxia and dizziness.

Mild encephalopathy with reversible splenial lesion associated with SARS-CoV-2 infection: A case report

Mild encephalopathy with reversible splenial lesion (MERS) is characterized with a reversible lesion in the splenium of the corpus callosum. It has been defined as a neuro-radiologic syndrome associated with viral infections. In addition, this lesion may related with epileptic seizures, antiepileptic drugs or metabolic disturbances. We presented a patient with MERS associated with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Encephalopathy and psychiatric symptoms were the major initial clinical symptoms. Brain magnetic resonance imaging showed complete resolution of the corpus callosum lesion. The symptoms of patient recovered completely. Complete resolution of corpus callosum lesion and recovery of encephalopathy associated with SARS-COV-2 were similar to previous cases.

Reversible Lesion of the Corpus Callosum Associated With COVID-19: A Case Report and Review of Literature

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system (CNS) and peripheral nervous system (PNS). Major CNS manifestations of SARS-CoV-2 include seizures, meningitis, meningoencephalitis, ischemic stroke, hemorrhagic stroke, anosmia, hypogeusia, acute disseminated encephalomyelitis, hemorrhagic necrotizing encephalopathy, and nonfocal phenomena including lethargy, agitation, confusion, headache, and ataxia. The reversible splenial lesion syndrome (MERS) was first described in 2004. Although MERS was initially recognized as a benign phenomenon, a second type of MERS was identified in later years, which has a poor prognosis and potentially serious sequela. MERS can be caused by numerous etiologies including viruses. In this report, we present a patient with SARS-CoV-2 who presented with ataxia and dizziness as the clinical symptoms of MERS, which is a rare clinical phenomenon and can be caused by numerous etiologies.