Wash-Out of Intraparenchymally Injected Xenon-133 as a Parameter of Liver Blood Flow in the Dog

1975 ◽  
Vol 35 (7) ◽  
pp. 635-639 ◽  
Author(s):  
C. Hall ◽  
A. Bergan ◽  
J. E. Henriksen
1985 ◽  
Vol 5 (5) ◽  
pp. 433-442 ◽  
Author(s):  
S. A. Jenkins ◽  
A. Taylor ◽  
S. K. Shimirty ◽  
J. Johnson ◽  
J. N. Baxter ◽  
...  

1992 ◽  
Vol 67 (01) ◽  
pp. 083-087 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J M Kroon ◽  
F J Kasper ◽  
H C Schoemaker ◽  
...  

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.


2002 ◽  
Vol 85 (11) ◽  
pp. 2831-2842 ◽  
Author(s):  
S. Sangsritavong ◽  
D.K. Combs ◽  
R. Sartori ◽  
L.E. Armentano ◽  
M.C. Wiltbank

1995 ◽  
Vol 59 (3) ◽  
pp. 614-620 ◽  
Author(s):  
David J. Cook ◽  
Robert E. Anderson ◽  
John D. Michenfelder ◽  
William C. Oliver ◽  
Thomas A. Orszulak ◽  
...  

1993 ◽  
Vol 19 (3) ◽  
pp. 377-382 ◽  
Author(s):  
Hans U. Baer ◽  
Tommaso Guastella ◽  
Anthony M. Wheatley ◽  
Arthur Zimmermann ◽  
Leslie H. Blumgart

1989 ◽  
Vol 59 (3) ◽  
pp. 410-414 ◽  
Author(s):  
TM Hunt ◽  
ADS Flowerdew ◽  
AJ Britten ◽  
JS Fleming ◽  
SJ Karran ◽  
...  
Keyword(s):  

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