The Inhibitory Effect of Coli-Endotoxin on Alpha-Adrenergic Receptor Functions in the Lower Urinary Tract

1977 ◽  
Vol 11 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Arne Nergårdh ◽  
Lars O. Boréus ◽  
Tord Holme
Keyword(s):  
Urinary Tract ◽  
Adrenergic Receptor ◽  
Lower Urinary Tract ◽  
Inhibitory Effect ◽  
Alpha Adrenergic Receptor ◽  
Lower Urinary

Inhibitory effect of neuropeptide Y on adrenergic and cholinergic transmission in rat urinary bladder and urethra

1994 ◽  
Vol 266 (4) ◽  
pp. R1411-R1417 ◽  
Author(s):  
L. V. Tran ◽  
G. T. Somogyi ◽  
W. C. De Groat
Keyword(s):  
Urinary Tract ◽  
Neuropeptide Y ◽  
Lower Urinary Tract ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Ach Release ◽  
High Concentration ◽  
Rat Urinary Bladder ◽  
Dose Dependent ◽  
Lower Urinary

The effects of porcine neuropeptide Y (NPY) on electrically evoked release of [3H]norepinephrine ([3H]NE) and [3H]acetylcholine ([3H]ACh) were investigated in isolated preparations of the rat lower urinary tract. In the urethra, NPY (0.02-0.5 microM) decreased the release of [3H]NE in a dose-dependent manner (10-53%). In the bladder base the inhibitory effect of NPY on [3H]NE release was not dose dependent. A low concentration (0.1 microM) decreased the release (38%), whereas a high concentration (0.5 microM) had no effect. However, in atropine-treated preparations, 0.5 microM NPY elicited a significant inhibition (43%). These observations suggest that 0.5 microM NPY elicits two opposing actions: a direct inhibitory action on adrenergic terminals and an indirect disinhibitory action to eliminate heterosynaptic cholinergic inhibition of [3H]NE release. In both tissues the action of NPY on [3H]NE release was not significantly modified by the alpha-adrenergic blocking agent yohimbine (1 microM). [3H]ACh release in the bladder body was not altered by 0.1 microM NPY but was suppressed (39%) by 1 microM NPY. The effect of NPY (1 microM) on [3H]ACh release was dependent on the frequency of stimulation. NPY suppressed the release at 2-Hz stimulation but had no significant effect at 20 Hz. These results suggest that NPY may have an important role in the neural regulation of the lower urinary tract by exerting differential effects on the release of cholinergic and adrenergic transmitters via autoinhibition and heterosynaptic interactions.

β 3 -ADRENERGIC RECEPTOR GENE POLYMORPHISMS AND LOWER URINARY TRACT FUNCTION

2009 ◽  
Vol 181 (4S) ◽  
pp. 150-150
Author(s):  
Martin C Michel ◽  
Christine A Teitsma ◽  
Wim Vrydag ◽  
Frank Baas ◽  
Jean de la Rosette
Keyword(s):  
Urinary Tract ◽  
Adrenergic Receptor ◽  
Gene Polymorphisms ◽  
Lower Urinary Tract ◽  
Receptor Gene ◽  
Lower Urinary Tract Function ◽  
Tract Function ◽  
Receptor Gene Polymorphisms ◽  
Adrenergic Receptor Gene ◽  
Lower Urinary
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