Negative Middle Ear Pressure and Hearing Thresholds in Secretory Otitis Media: A Double-blind Crossover Study with Lunerin

1980 ◽  
Vol 9 (3) ◽  
pp. 171-176 ◽  
Author(s):  
P. Møller
1986 ◽  
Vol 95 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Paul R. Lambert

A prospective, double-blind crossover study design was used in the evaluation of the role of prednisone in the treatment of a chronic middle ear effusion. Sixty children with an effusion—of at least 2 months’ duration—randomly received either prednisone or placebo for 2 weeks. One week later they were re-evaluated. If the effusion had resolved, they were followed periodically; if the effusion persisted, they were given the crossover regimen and reevaluated. Sixty percent of the patients’ effusions cleared, but there was no statistical difference between the prednisone and placebo groups. The amount of hearing recovery was also the same for both treatment regimens. Subdividing the patients on the basis of effusion duration, unilateral vs. bilateral effusions, or history of ventilation tubes or antibiotics failed to identify a subgroup of individuals who might benefit from a short-term course of oral steroids.


1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.


Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 696
Author(s):  
Neus Bosch-Sierra ◽  
Roger Marqués-Cardete ◽  
Aránzazu Gurrea-Martínez ◽  
Carmen Grau-Del Valle ◽  
Clara Talens ◽  
...  

The authors have requested that the following changes be made to their paper [...]


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