Quantification of Texture Match of the Skin Graft: Function and Morphology of the Stratum Corneum

1986 ◽  
Vol 20 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Kunio Inoue ◽  
Kichiro Matsumoto
1983 ◽  
Vol 72 (4) ◽  
pp. 453
Author(s):  
Kunio Inoue ◽  
Hachiro Tagami ◽  
Takahiko Moriguchi ◽  
Kodo Yoshikuni ◽  
Mizuho Yamada ◽  
...  

1983 ◽  
Vol 72 (4) ◽  
pp. 448-452 ◽  
Author(s):  
Kunio Inoue ◽  
Hachiro Tagami ◽  
Takahiko Moriguchi ◽  
Kodo Yoshikuni ◽  
Mizuho Yamada

Author(s):  
R. R. Warner

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.


Author(s):  
S. Trachtenberg ◽  
P.M. Steinert ◽  
B.L. Trus ◽  
A.C. Steven

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.


2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
S. Li ◽  
S. Korkmaz-Icöz ◽  
T. Radovits ◽  
P. Hegedűs ◽  
M. Karck ◽  
...  
Keyword(s):  

2005 ◽  
Vol 5 (03) ◽  
pp. 141-143
Author(s):  
Andreas Merkenschlager ◽  
Matthias Bernhard
Keyword(s):  

ZusammenfassungAkzidentelle Vergiftungen ereignen sich am häufigsten im Kleinkindesalter. Der weit verbreitete Gebrauch von aliphatischen Hydrokarbonen wie Dieselöl begünstigt Intoxikationen. Die Ingestion von Dieseltreibstoff birgt insbesondere die Gefahr einer Aspirationspneumonie. Akute Hauttoxizität ist hingegen selten.Ein 15 Monate altes Mädchen entwickelte nach vorausgegangenem Erbrechen und einer mehrere Stunden andauernden Lethargie innerhalb von 24 Stunden zahlreiche bläschenartige Hautläsionen, die teilweise ulzeriert waren, an den Fingern, der Handinnenfläche sowie perioral. Die Wangen- und Gaumensegelschleimhaut zeigten mehrere kleine Ulzera, die weißlich belegt und hämorrhagisch waren. Zunächst wurde eine Hand-Fuß-Mund-Krankheit vermutet. Durch ausführliche Anamnese konnte jedoch festgestellt werden, dass das Kind am Tag zuvor in einem Sandkasten gespielt hatte, der durch ein Leck in einem daneben stehenden Dieselöltank kontaminiert gewesen war. Eine pulmonale oder hepatische Beteiligung konnte nicht nachgewiesen werden. Die Läsionen heilten vollständig unter antiseptischen Verbänden innerhalb einer Woche ab.Man nimmt an, dass Dieselöl primär das Stratum corneum der Haut schädigt. Kinder sind aufgrund ihrer gegenüber Erwachsenen dünneren Hornhaut gefährdeter. In seltenen Fällen können sich Vesikel, Ulzera und Hämorrhagien entwickeln, die mit Infektionskrankheiten verwechselt werden können.Unstimmigkeiten bei klinischen Befunden sollten insbesondere bei Kleinkindern immer an mögliche Intoxikationen denken lassen.


Author(s):  
Domenico Pagliara ◽  
Maria Lucia Mangialardi ◽  
Stefano Vitagliano ◽  
Valentina Pino ◽  
Marzia Salgarello

Abstract Background After anterolateral thigh (ALT) flap harvesting, skin graft of the donor site is commonly performed. When the defect width exceeds 8 cm or 16% of thigh circumference, it can determine lower limb function impairment and poor aesthetic outcomes. In our comparative study, we assessed the functional and aesthetic outcomes related to ALT donor-site closure with split-thickness skin graft compared with thigh propeller flap. Methods We enrolled 60 patients with ALT flap donor sites. We considered two groups of ALT donor-site reconstructions: graft group (30 patients) with split-thickness skin graft and flap group (30 patients) with local perforator-based propeller flap. We assessed for each patient the range of motion (ROM) at the hip and knee, tension, numbness, paresthesia, tactile sensitivity, and gait. Regarding the impact on daily life activities, patients completed the lower extremity functional scale (LEFS) questionnaire. Patient satisfaction for aesthetic outcome was obtained with a 5-point Likert scale (from very poor to excellent). Results In the propeller flap group, the ROMs of hip and knee and the LEFS score were significantly higher. At 12-month follow-up, in the graft group, 23 patients reported tension, 19 numbness, 16 paresthesia, 22 reduction of tactile sensitivity, and 5 alteration of gait versus only 5 patients experienced paresthesia and 7 reduction of tactile sensitivity in the propeller flap group. The satisfaction for aesthetic outcome was significantly higher in the propeller flap group. Conclusion In high-tension ALT donor-site closure, the propeller perforator flap should always be considered to avoid split-thickness skin graft with related functional and aesthetic poor results.


2019 ◽  
Vol 46 (4) ◽  
Author(s):  
Hayra Diah Avianggi ◽  
Intan Nurmawati Putri ◽  
Muslimin ◽  
Retno Indar Widayati
Keyword(s):  

Karsinoma sel basal (KSB) tercatat sebanyak 75% dari semua kanker kulit. Data epidemiologis dunia menunjukkan peningkatan insidensi KSB 3-10% dalam setahun, hal ini diduga berkaitan dengan penipisan lapisan ozon (2% dalam 20 tahun terakhir) dan perubahan gaya hidup. Karsinoma sel basal (KSB) dapat menyebabkan cacat kosmetik maupun cacat fungsional sehingga diperlukan diagnosis dini dan penatalaksanaan yang tepat. Seorang perempuan 72 tahun, dengan keluhan benjolan yang semakin membesar kemudian menjadi borok di pelipis kiri sejak satu tahun. Riwayat sering terpajan sinar matahari. Pada pemeriksaan fisik ditemukan ulkus dengan diameter 3 cm dan krusta. Temuan histopatologik menunjukkan sel ganas dengan inti hiperkromatik dan tepi palisade. Penatalaksanaan dengan bedah eksisi, flap rotasi dan skin graft. KSB jarang bermetastasis, namun dapat mendestruksi jaringan di dekatnya. Studi epidemiologi memberikan fakta bahwa patogenesis KSB dapat terjadi melalui efek imunologik dan karsinogenik. Gambaran histopatologik penting untuk menentukan varian KSB. Prognosis quo ad vitam bonam, ad sanam dubia ad bonam, ad kosmetikam dubia ad bonam.Kata kunci: Bedah eksisi, flap rotasi, karsinoma sel basal, skin graft


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