Frequency of three prothrombotic polymorphisms among Syrian population: factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T

2015 ◽  
Vol 44 (1) ◽  
pp. 70-73
Author(s):  
Rami A. Jarjour ◽  
Samer Ammar ◽  
Rami Majdalawi
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Syrian Population ◽  
Factor V G1691a

Prevalence of Prothrombin G20210A, Factor V G1691A (Leiden), and Methylenetetrahydrofolate Reductase (MTHFR) C677T in Seven Different Populations Determined by Multiplex Allele-specific PCR

1999 ◽  
Vol 81 (05) ◽  
pp. 733-738 ◽  
Author(s):  
Robert Luhm ◽  
Steven Pearson ◽  
Debra Endean ◽  
Kenneth Friedman ◽  
Robert Montgomery ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Specific Pcr ◽  
Factor V G1691a ◽  
Allele Specific ◽  
Allele Specific Pcr ◽  
Prothrombin 20210A

SummaryIndividuals belonging to six racial groups (African American, Asian Indian, Caucasian, Hispanic, Korean, Native American), and a seventh group comprised of referred patients with thrombosis were genotyped for the prothrombin G20210A mutation, the factor V G1691A (Leiden) mutation, and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation by multiplexed allele-specific PCR. The prothrombin 20210A and factor V 1691A allele frequencies in the thrombosis patients, 3.2% and 9.5%, were significantly higher than those in the random Caucasians, 1.3% and 1.8%, (p = 0.043 and p <0.001, respectively). The relative risk of venous thrombosis was determined to be 2.4-fold for carriers of the prothrombin 20210A allele (odds ratio = 2.54; 95% confidence interval = 0.94, 6.82) and 4.5-fold for carriers of the factor V 1691A allele (odds ratio = 5.06; 95% confidence interval = 2.25, 11.36). Among the seven populations, significant differences were observed in the MTHFR 677T allele distribution, however this mutation was not determined to be a risk factor for venous thrombosis in the patient group studied, either alone or in combination with the pro-thrombin 20210A and/or the factor V 1691A allele(s).

scholarly journals Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population

2002 ◽  
Vol 71 (4) ◽  
pp. 300-305 ◽  
Author(s):  
Ramzi R. Finan ◽  
Hala Tamim ◽  
Ghada Ameen ◽  
Huda E. Sharida ◽  
Mooza Rashid ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Gene Mutations ◽  
Factor V Leiden ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Factor V G1691a

Prevalence of the Factor V G1691A and the Factor II/prothrombin G20210A gene polymorphisms among Tamilians

2005 ◽  
Vol 79 (1) ◽  
pp. 9-13 ◽  
Author(s):  
T. Angeline ◽  
Heather A. Bentley ◽  
Arnold B. Hawk ◽  
Richard J. Manners ◽  
Harsha A. Mokashi ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Factor Ii ◽  
Factor V G1691a
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