A Mixture Experiment Approach for Controlling the Dissolution Rate of a Sustained-Release Tablet

1998 ◽  
Vol 24 (9) ◽  
pp. 799-806 ◽  
Author(s):  
Jean-Marie Geoffroy ◽  
Jennifer K. Fredrickson ◽  
John T. Shelton
1982 ◽  
Vol 10 (1) ◽  
pp. 17-24 ◽  
Author(s):  
P.B. Daly ◽  
S.S. Davis ◽  
M. Frier ◽  
J.G. Hardy ◽  
J.W. Kennerley ◽  
...  

Polymer Korea ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 332-337
Author(s):  
Jae-Uk Cha ◽  
Ja-Hyun Cha ◽  
Jun-Kee Hong ◽  
Sung-Wan Lee ◽  
Won-Hwa Ko ◽  
...  

1985 ◽  
Vol 24 (2-3) ◽  
pp. 355-358 ◽  
Author(s):  
S.K. Baveja ◽  
K.V. Ranga Rao ◽  
Rajinder Kumar ◽  
K. Padmalatha Devi

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 61-67
Author(s):  
P. P Dighe ◽  
H. M Tank ◽  

Pulmonary arterial hypertension (PAH) means high blood pressure in the lungs caused by obstruction in the small arteries of the lungs.The current study involves the fabrication of oral matrix sustained release tablet of bosentan monohydrate, a dual endothelin receptor antagonist, the optimisation of its in vitro release and characterisation. Methocel K4M PremiumDC2, a directly compressible HPMC grade, has been used as the sustained release polymer. Pregelatinised starch is used as a diluent and release modifier and sodium lauryl sulphate as a solubiliser. The influence of the above variables on drug release is measured using a 23 factorial design using design expert software. Surface response plots show significant interaction among the formulation variables, thus aiding in optimization of bilayer tablet.


2014 ◽  
Vol 01 (03) ◽  
pp. 78-84 ◽  
Author(s):  
Gayatri D Medisetty ◽  
Girish B Botta ◽  
Uma maheshwari Yamana ◽  
Ashwini Avasarala

2004 ◽  
Vol 9 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Omaima N. El‐Gazayerly ◽  
Vipaporn Rakkanka ◽  
James W. Ayres

2011 ◽  
Vol 49 (09) ◽  
pp. 750-753
Author(s):  
Poondru Srinivasu ◽  
Devraj Rambhau ◽  
Boinpally Rao ◽  
Yamsani Rao

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