B-Cell Antigen Receptor Signaling in Chronic Lymphocytic Leukemia: Therapeutic Targets and Translational Opportunities

2013 ◽  
Vol 32 (4) ◽  
pp. 377-396 ◽  
Author(s):  
Ronald J. Hill ◽  
Yan Lou ◽  
Seng-Lai Tan
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Therapeutic Targets ◽  
Antigen Receptor ◽  
Lymphocytic Leukemia ◽  
B Cell Antigen Receptor ◽  
Receptor Signaling ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Antigen Receptor Signaling

scholarly journals The B cell antigen receptor in atypical chronic lymphocytic leukemia with t(14;19)(q32;q13) demonstrates remarkable stereotypy

2010 ◽  
Vol 128 (11) ◽  
pp. 2759-2764 ◽  
Author(s):  
Carmen D. Schweighofer ◽  
Yang O. Huh ◽  
Rajyalakshmi Luthra ◽  
Rachel L. Sargent ◽  
Rhett P. Ketterling ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Antigen Receptor ◽  
Lymphocytic Leukemia ◽  
B Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen

scholarly journals B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events

PLoS Biology ◽  
2006 ◽  
Vol 4 (7) ◽  
pp. e200 ◽  
Author(s):  
Ping Hou ◽  
Elizabeth Araujo ◽  
Tong Zhao ◽  
Miao Zhang ◽  
Don Massenburg ◽  
...  
Keyword(s):  
B Cell ◽  
Antigen Receptor ◽  
B Cell Antigen Receptor ◽  
Receptor Signaling ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Antigen Receptor Signaling

scholarly journals Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling

2008 ◽  
Vol 283 (25) ◽  
pp. 16971-16984 ◽  
Author(s):  
Claire A. Walshe ◽  
Stephen A. Beers ◽  
Ruth R. French ◽  
Claude H. T. Chan ◽  
Peter W. Johnson ◽  
...  
Keyword(s):  
B Cell ◽  
Antigen Receptor ◽  
Cytosolic Calcium ◽  
Calcium Flux ◽  
B Cell Antigen Receptor ◽  
Receptor Signaling ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Antigen Receptor Signaling

scholarly journals Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function.

1996 ◽  
Vol 16 (9) ◽  
pp. 5026-5035 ◽  
Author(s):  
G Kong ◽  
M Dalton ◽  
J Bubeck Wardenburg ◽  
D Straus ◽  
T Kurosaki ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
Tyrosine Phosphorylation ◽  
Antigen Receptor ◽  
B Cell Antigen Receptor ◽  
Receptor Signaling ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Antigen Receptor Signaling

Biochemical and genetic evidence has implicated two families of protein tyrosine kinases (PTKs), the Src- and Syk-PTKs, in T- and B-cell antigen receptor signaling. ZAP-70 is a member of the Syk-PTKs that associates with the T-cell antigen receptor and undergoes tyrosine phosphorylation following receptor activation. Three tyrosine residues, Tyr-292, -492, and -493, have been identified as sites of phosphorylation following T-cell antigen receptor engagement. Utilizing ZAP-70- and Syk-deficient lymphocytes (Syk-DT40 cells), we provide biochemical and functional evidence that heterologous trans-phosphorylation of Tyr-493 by a Src-PTK is required for antigen receptor-mediated activation of both the calcium and ras pathways. In contrast, cells expressing mutations at Tyr-292 or -492 demonstrate hyperactive T- and B-cell antigen receptor phenotypes. Thus, phosphorylation of ZAP-70 mediates both activation and inactivation of antigen receptor signaling.

scholarly journals Requirement for CD100–CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment

2005 ◽  
Vol 17 (10) ◽  
pp. 1277-1282 ◽  
Author(s):  
Atsushi Kumanogoh ◽  
Takashi Shikina ◽  
Chie Watanabe ◽  
Noriko Takegahara ◽  
Kazuhiro Suzuki ◽  
...  
Keyword(s):  
B Cell ◽  
Antigen Receptor ◽  
Fine Tuning ◽  
B Cell Antigen Receptor ◽  
Receptor Signaling ◽  
Cell Compartment ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Antigen Receptor Signaling
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