scholarly journals Fourth Cranial Nerve Palsy and Bilateral Acute Retinal Necrosis following Human Herpesvirus 6 Infection of the Central Nervous System

2013 ◽  
Vol 22 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Eleni Papageorgiou ◽  
Soon Ch'ng ◽  
Archana Kulkarni ◽  
Samira Anwar ◽  
Theodoros Empeslidis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cranial Nerve ◽  
Cranial Nerve Palsy ◽  
Nerve Palsy ◽  
Human Herpesvirus ◽  
Acute Retinal Necrosis ◽  
Human Herpesvirus 6 ◽  
The Central Nervous System ◽  
Fourth Cranial Nerve

scholarly journals Isolated 6th cranial nerve palsy: a rare manifestation of tuberculosis

2021 ◽  
Vol 7 (8) ◽  
pp. 1365
Author(s):  
Shehnaz Kantharia ◽  
Rajesh A. Kantharia ◽  
Pradeepkran Reddy P.
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cranial Nerve ◽  
Nerve Palsy ◽  
Abducens Nerve ◽  
Seventh Cranial Nerve ◽  
Rare Manifestation ◽  
The Central Nervous System ◽  
Open Surgical Procedure ◽  
The Brain

<p>Tuberculosis (TB) is a contagious infection that is usually caused by <em>Mycobacterium tuberculosis</em> bacteria. It usually affects the lungs and also spreads to the brain and spine. In the central nervous system, the neurological manifestations are numerous and varied and usually occur in two major forms, tuberculous meningitis and tuberculoma. Tuberculoma are well defined, granulomatous, space occupying lesions, which can occur anywhere in the central nervous system. Usually, brainstem tuberculoma can cause sixth and seventh cranial nerve affections along with motor and sensory symptoms, which are usually unilateral. Isolated abducens nerve palsy could be attributed to lesions of the nerve along their extra axial course and cause diplopia. Here we are presenting a case report of an 18-year-old boy with isolated sixth nerve palsy due to tuberculosis. The diagnosis of tuberculosis was achieved using interventional radiology for the purpose of biopsy. Using an image guided technique, we could avoid an open surgical procedure. </p>

Human Herpesvirus 6 (HHV-6) Infection in the Central Nervous System

1992 ◽  
Vol 34 (3) ◽  
pp. 337-343 ◽  
Author(s):  
Koichi Yamanishi ◽  
Kazuhiro Kondo ◽  
Tetsu Mukai ◽  
Toshio Kondo ◽  
Hiroshi Nagafuji ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
The Central Nervous System ◽  
Herpesvirus 6

scholarly journals Multiple sclerosis and herpesvirus interaction

2013 ◽  
Vol 71 (9B) ◽  
pp. 727-730 ◽  
Author(s):  
Guilherme Sciascia do Olival ◽  
Bruna Mendonca Lima ◽  
Laura M. Sumita ◽  
Vitor Serafim ◽  
Maria Cristina Fink ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Demyelinating Disease ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
The Central Nervous System ◽  
Herpesvirus 6 ◽  
Epstein Barr

Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions.

scholarly journals Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

2011 ◽  
Vol 108 (33) ◽  
pp. 13734-13739 ◽  
Author(s):  
E. Harberts ◽  
K. Yao ◽  
J. E. Wohler ◽  
D. Maric ◽  
J. Ohayon ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Olfactory Pathway ◽  
The Central Nervous System ◽  
Herpesvirus 6

Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease

2004 ◽  
Vol 10 (4) ◽  
pp. 348-354 ◽  
Author(s):  
A Rotola ◽  
I Merlotti ◽  
L Caniatti ◽  
E Caselli ◽  
E Granieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Human Herpesvirus ◽  
Clinical Samples ◽  
Human Herpesvirus 6 ◽  
Early Stages ◽  
The Central Nervous System ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

The presence and the replicative state of human herpesvirus 6 (HHV-6) were evaluated in clinical samples from multiple sclerosis (MS) patients at the first time of MS diagnosis. HHV-6 variant B was present in peripheral blood mononuclear cells of 5/32 (15%) patients, but persisted with a latent infection. Viral sequences were present also in cerebrospinal fluid (CSF), both free in the liquid (7/32, 22%) and latent in the cellular fraction (3/32, 9%), as shown by analysis of viral transcription. In these cases, variant A was detected. HHV-6 DNA sequences present in the CSF were associated to mature viral particles. In fact, in vitro infectious assays of CSF showed the presence of replication-competent virions. These results show that about 20% of MS patients have active foci of HHV-6 variant A infection in the early stages of the disease and suggest that viral replication takes place within the central nervous system.

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