scholarly journals Molecular characteristics of diffuse large B-cell lymphoma in human immunodeficiency virus-infected and -uninfected patients in the pre-highly active antiretroviral therapy and pre-rituximab era

2013 ◽  
Vol 55 (3) ◽  
pp. 551-557 ◽  
Author(s):  
Lindsay M. Morton ◽  
Clara J. Kim ◽  
Lawrence M. Weiss ◽  
Kishor Bhatia ◽  
Myles Cockburn ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Molecular Characteristics ◽  
Highly Active ◽  
Large B Cell Lymphoma ◽  
Immunodeficiency Virus ◽  
Large B Cell

Stage IV advanced diffuse large B-cell lymphoma in human immunodeficiency virus infection with achieving cure by using highly active antiretroviral therapy alone: a case report

2017 ◽  
Vol 28 (9) ◽  
pp. 932-936 ◽  
Author(s):  
Do Hyoung Lim ◽  
Ji-Young Rhee ◽  
Keon Woo Park
Keyword(s):  
Antiretroviral Therapy ◽  
B Cell ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Lymphoma ◽  
Stage Iv ◽  
B Cell Lymphoma ◽  
High Grade ◽  
Highly Active ◽  
Large B Cell Lymphoma ◽  
Large B Cell

After the introduction of highly active antiretroviral therapy (HAART), there has been a decrease in the incidence of lymphoma among the HIV-infected population and also significantly improved survival rates. We describe a remarkable case of an HIV-infected patient with advanced stage IV diffuse large B-cell lymphoma (DLBCL), completely regressed with the use of HAART alone. He remained disease-free for 6 years and he achieved cure without chemotherapy. Although several cases of low-grade lymphoma with complete regression were reported, we could not find any case of stage IV high-grade malignant lymphoma with HAART alone in complete remission for over 5 years from our review of the literature. This unique case shows the importance of HAART in improving survival and achieving cure in HIV–high-grade malignant lymphoma.

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