Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk

2016 ◽  
Vol 57 (12) ◽  
pp. 2855-2862 ◽  
Author(s):  
Liling Su ◽  
Yue Fei ◽  
Xiaoxia Wei ◽  
Jing Guo ◽  
Xiangen Jiang ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Childhood Leukemia ◽  
Low Frequency ◽  
Extremely Low Frequency ◽  
Parental Occupational Exposure

scholarly journals Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)

2019 ◽  
Vol 76 (10) ◽  
pp. 746-753 ◽  
Author(s):  
Madar Talibov ◽  
Ann Olsson ◽  
Helen Bailey ◽  
Friederike Erdmann ◽  
Catherine Metayer ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Childhood Leukemia ◽  
Low Frequency ◽  
Exposure Level ◽  
Childhood Leukaemia ◽  
Case Control Studies ◽  
International Consortium ◽  
Parental Occupational Exposure ◽  
Meta Analyses

ObjectivesPreviously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium.MethodsWe pooled 11 case–control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses.ResultsORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (µT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 µT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.ConclusionsIn this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

scholarly journals O1B.2 Parental occupational exposure to extremely low-frequency magnetic fields and the risk of leukaemia in the offspring

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A5.1-A5
Author(s):  
Madar Talibov
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Low Frequency ◽  
Developed Countries ◽  
Exposure Level ◽  
Childhood Leukaemia ◽  
Extremely Low Frequency ◽  
Parental Occupational Exposure ◽  
Meta Analyses ◽  
Analytical Approaches

BackgroundLeukaemia is the most common cancer diagnosed in children worldwide, accounting for about one third of all paediatric malignancies in economically developed countries. Despite extensive research, the aetiology of this cancer remains largely unknown. Previous studies suggested that parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) may increase leukaemia risk in the offspring.ObjectiveWe aimed to evaluate the association of parental occupational exposure to ELF-MF with the risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring.MethodsWe pooled data from 11 case-control studies participating in the Childhood Leukaemia International Consortium (CLIC). The studies included 9723 childhood leukaemia cases and 17 099 controls. Data on parental job history and other characteristics of the study population were collected by questionnaires and interviews, except for the Finnish study where data was obtained from population registries and censuses. Parental occupational ELF-MF exposure was estimated by linking job histories to an independently developed international ELF-MF job-exposure matrix. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). We employed two analytical approaches to obtain summary risk estimates. First, we conducted pooled analyses of all studies combined. Second, we summarized ORs from individual studies in meta-analyses.ResultsThe summary OR estimates from pooled analyses for paternal ELF-MF exposure at conception were 1.04 (95% CI 0.95–1.13) for ALL and 1.06 (95% CI 0.87–1.29) for AML, at >0.2 microtesla (µT) compared to ≤0.2 µT. Corresponding estimates for maternal ELF-MF exposure during pregnancy, using again the 0.2 µT cut-off, were 1.00 (95% CI 0.89–1.12) for ALL and 0.85 (95% CI 0.61–1.16) for AML. No trends with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.ConclusionOur study did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

Occupational Exposure to Electric Shocks and Extremely Low-Frequency Magnetic Fields and Motor Neurone Disease

2020 ◽  
Author(s):  
Grace X Chen ◽  
Andrea’t Mannetje ◽  
Jeroen Douwes ◽  
Leonard H Berg ◽  
Neil Pearce ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Low Frequency ◽  
Population Based ◽  
Motor Neurone ◽  
Motor Neurone Disease ◽  
Cumulative Exposure ◽  
Spine Injury ◽  
Extremely Low Frequency ◽  
Electric Shocks

Abstract In a New Zealand population-based case-control study we assessed associations with occupational exposure to electric shocks, extremely low-frequency magnetic fields (ELF-MF) and motor neurone disease using job-exposure matrices to assess exposure. Participants were recruited between 2013 and 2016. Associations with ever/never, duration, and cumulative exposure were assessed using logistic regression adjusted for age, sex, ethnicity, socioeconomic status, education, smoking, alcohol consumption, sports, head or spine injury and solvents, and mutually adjusted for the other exposure. All analyses were repeated stratified by sex. An elevated risk was observed for having ever worked in a job with potential for electric shocks (odds ratio (OR)=1.35, 95% confidence interval (CI): 0.98, 1.86), with the strongest association for the highest level of exposure (OR=2.01, 95%CI: 1.31, 3.09). Analysis by duration suggested a non-linear association: risk was increased for both short-duration (<3 years) (OR= 4.69, 95%CI: 2.25, 9.77) and long-duration in a job with high level of electric shock exposure (>24 years; OR=1.88; 95%CI: 1.05, 3.36), with less pronounced associations for intermediate durations. No association with ELF-MF was found. Our findings provide support for an association between occupational exposure to electric shocks and motor neurone disease but did not show associations with exposure to work-related ELF-MF.

scholarly journals O4A.6 Occupational exposure to extremely low frequency magnetic fields and melatonin in male rotating shift workers

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A33.3-A33
Author(s):  
Michelle C Turner ◽  
Esther Gracia-Lavedan ◽  
Gemma Castaño-Vinyals ◽  
Debra J Skene ◽  
Benita Middleton ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Magnetic Fields ◽  
Geometric Mean ◽  
Night Shift ◽  
Low Frequency ◽  
Personal Characteristics ◽  
Peak Time ◽  
Shift Workers ◽  
Extremely Low Frequency ◽  
Melatonin Production

BackgroundOccupational exposure to extremely low frequency magnetic fields (ELF-MF) is a suspected cancer risk factor, however, the epidemiological literature is limited and potential biological mechanisms unclear. Night shift work and associated circadian misalignment, leading to decreased melatonin production is also suspected in cancer. It has been suggested that ELF-MF exposure may decrease melatonin production leading to the promotion of cancer development, however previous findings are inconsistent. We assessed ELF-MF exposure and melatonin production in a recent study of male rotating shift workers.MethodsA total of 50 male shift workers rotating in a 3 week night, 3 week evening, and 3 week morning schedule were recruited at a local car manufacturing facility. Personal full-shift measurements of ELF-MF exposure were performed (EMDEX II, 40–800 Hz) and urine samples from all voids over 24 hour collected on two working days (end of 3 week night and end of 3 week morning shifts). Urinary concentrations of 6-sulfatoxymelatonin (aMT6s), the main melatonin metabolite, were measured in all samples (creatinine corrected), with the mesor (24 hour mean) derived based on cosinor models.ResultsArithmetic mean (AM (SD)) and geometric mean (GM (GSD)) ELF-MF levels were 0.05 (0.06) µT and 0.03 (0.02) µT, respectively. Peak production of aMT6s occurred 9 hours later in night compared with morning shifts, though with a similar mesor indicating adaptation. The adjusted mesor varied somewhat by age group and other personal characteristics, and was somewhat lower among those with higher AM and GM ELF-MF levels (i.e. ≥50 th or 75th percentile), with differences ranging from 0.94–1.38 ng/mg creatinine/hour in the morning to 0.96–4.33 in the night shift observed, with some differences significant.ConclusionsOverall, small differences in mean aMT6s levels were observed according to ELF-MF. Workers during the night shift adapted, showing a delay in the peak time of aMT6s production compared to the day shift.

scholarly journals Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukemia?

2002 ◽  
Vol 7 (2) ◽  
pp. 33-39 ◽  
Author(s):  
Pagona Lagiou ◽  
Rulla Tamimi ◽  
Areti Lagiou ◽  
Lorelei Mucci ◽  
Dimitrios Trichopoulos
Keyword(s):  
Magnetic Fields ◽  
Childhood Leukemia ◽  
Low Frequency ◽  
Extremely Low Frequency ◽  
Electric And Magnetic Fields
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