Targeted Delivery of Electrical Shocks and Epinephrine, Guided by Ventricular Fibrillation Amplitude Spectral Area, Reduces Electrical and Adrenergic Myocardial Burden, Improving Survival in Swine

Background We previously reported that resuscitation delivering electrical shocks guided by real‐time ventricular fibrillation amplitude spectral area (AMSA) enabled return of spontaneous circulation (ROSC) with fewer shocks, resulting in less myocardial dysfunction. We now hypothesized that AMSA could also guide delivery of epinephrine, expecting further outcome improvement consequent to less electrical and adrenergic burdens. Methods and Results A swine model of ventricular fibrillation was used to compare after 10 minutes of untreated ventricular fibrillation a guidelines‐driven (n=8) resuscitation protocol, delivering shocks every 2 minutes and epinephrine every 4 minutes, with an AMSA‐driven shocks (n=8) protocol, delivering epinephrine every 4 minutes, and with an AMSA‐driven shocks and epinephrine (ADSE; n=8) protocol. For guidelines‐driven, AMSA‐driven shocks, and ADSE protocols, the time to ROSC (mean±SD) was 569±164, 410±111, and 400±80 seconds ( P =0.045); the number of shocks (mean±SD) was 5±2, 3±1, and 3±2 ( P =0.024) with ADSE fewer than guidelines‐driven ( P =0.03); and the doses of epinephrine (median [interquartile range]) were 2.0 (1.3–3.0), 1.0 (1.0–2.8), and 1.0 (0.3–3.0) ( P =0.419). The ROSC rate was similar, yet survival after ROSC favored AMSA‐driven protocols (guidelines‐driven, 3/6; AMSA‐driven shocks, 6/6; and ADSE, 7/7; P =0.019 by log‐rank test). Left ventricular function and survival after ROSC correlated inversely with electrical burden (ie, cumulative unsuccessful shocks, J/kg; P =0.020 and P =0.046) and adrenergic burden (ie, total epinephrine doses, mg/kg; P =0.042 and P =0.002). Conclusions Despite similar ROSC rates achieved with all 3 protocols, AMSA‐driven shocks and ADSE resulted in less postresuscitation myocardial dysfunction and better survival, attributed to attaining ROSC with less electrical and adrenergic myocardial burdens.

Incidence and immediate consequences of electrical shocks among Danish electricians: a cohort study

ObjectivesThe health-related consequences of electrical shocks are mostly studied in patients from selected cohorts in hospital burn units, by making internal comparisons of subgroups, but without comparing them to unexposed individuals, or considering information regarding the preinjury health of the injured persons. Often, little is known about the details of the electrical shocks. Our purpose was to do a longitudinal study of Danish electrical workers, to monitor exposure to electrical shocks weekly over a 6-month period and to determine whether these shocks have short-term, health-related consequences.DesignProspective cohort study with weekly measurements.SettingMembers of the Danish Union of Electricians.ParticipantsOf the 22 284 invited, 6960 electricians (31%) participated in the baseline data collection, and the participation rate in the weekly follow-up ranged from 61% to 81% during the 6 month follow-up.Primary and secondary outcome measuresThe primary outcome measure was an electrical shock and secondary outcomes were the immediate health-related consequences of the shocks.ResultsA total of 2356 electrical shocks were reported by 1612 (23%) of the participants during the 26-week follow-up. Alternating current and voltage below 1000 V were the most common forms of electricity. In most cases, the fingers/hands were the entry and exit points, but many were unable to specify the exit point. The participants categorised 73% of the electrical shocks as ‘not at all severe’, and most of the shocks did not cause any immediate physical damage. However, flashbacks were more common than physical consequences. Only a few of the participants contacted health services following an electrical shock, and even fewer were absent from work.ConclusionNearly one-fourth of Danish electricians experienced one or more electrical shocks during a 26-week period, but most of the shocks are not perceived as severe, and have only limited immediate consequences.

Farmer Friendly Solar based Virtual Fencing for Rural Agriculture with Battery Reverse Charge Protection

Solar-based virtual fences use the principle of converting solar energy into electrical energy and giving electric shock while touching the fences. Electronic fence systems are used at many places such as forest areas, farms, etc. To protect those places against animals and thefts solar energy is converted to electrical energy to provide the necessary voltage for electrical fences As the Unregulated DC voltage from the solar energy is converted to regulated DC voltage and further converted to AC voltage using an inverter. And this electrical energy is used to give short but sharp shocks to the animals or anyone who touches the fence, But there is life threat through electrical shocks, as even though it is a short time shock it will be dangerous to life as it electrical energy and there will be chances of death, So we proposed a model of VIRTUAL FENCING technique which protects the farmland by scaring away the animals which tries to enter the fence protected land and at the same time it alerts the owner about the intrusion and lets the owner choose the type of defense to use remotely which is made possible in our model through a GSM module.

The Defibrillation Conundrum: New Insights into the Mechanisms of Shock-Related Myocardial Injury Sustained from a Life-Saving Therapy

Implantable cardiac defibrillators (ICDs) are recommended to prevent the risk of sudden cardiac death. However, shocks are associated with an increased mortality with a dose response effect, and a strategy of reducing electrical therapy burden improves the prognosis of implanted patients. We review the mechanisms of defibrillation and its consequences, including cell damage, metabolic remodeling, calcium metabolism anomalies, and inflammatory and pro-fibrotic remodeling. Electrical shocks do save lives, but also promote myocardial stunning, heart failure, and pro-arrhythmic effects as seen in electrical storms. Limiting unnecessary implantations and therapies and proposing new methods of defibrillation in the future are recommended.

Damnatio Memoriae

Are we just the sum of our memories? Is erasing all the memories of a person more, or less humane, than the death penalty? In this work of philosophical short story fiction, a member of the diplomatic corps recounts the history of Etescanate people and the evolution of their implantation of the death penalty over the centuries. Initially, the death penalty was a drawn out, painful and public affair. As time progressed, it remained public, but became more humane. With the advent of new technologies, it was moved indoors as a private affair where electrical shocks or injections were used. Now, the Etescanate people believe they have found the most humane form of capital punishment, complete memory erasure. Those that are found guilty of the most serious crimes are given a chemical cocktail that completely erases their minds of their entire past. There is one caveat to this punishment, while the government has outlawed killing by the state, it still leaves open the possibility of killing by others and, in some cases, the convicted opt to be killed privately instead.

Spermatogenesis Stimulation and Sperms' Activation by Direct and Gradual Electrical Shocks on Testis in Infertile Males

Background: Up to 15% of couples are infertile. In up to half of these couples, male infertility plays a role. Male infertility is caused by low sperm production, irregular sperm function, or blockages preventing the sperm delivery. Illnesses, accidents, chronic health issues, lifestyle choices and other factors can play a role in causing infertility among men.Methodology: It is a randomized controlled, single-blind clinical trial was conducted among 90 participants who have been diagnosed with (Oligospermia, Hypospermia, Asthenozoospermia or Necrozoospermia). Of a sample obtained by masturbation all the participants underwent a semen examination of their semen count, volume and motility. Then they got a small device, the device gives up to 5 milliamps of electrical shock. A final checkup for all was performed after the fourth months, and the data was collected and compared between (before and after) semen analysis.Results: The findings indicate an improvement in the count, volume and motility of the sperms after being shocked electrically in comparison with the control group. By using ANOVA-test, there were a statistically significant differences between the first seminal analysis result with each of the other results independently while it was not with the control group. Conclusion: Many treatments are available for infertility and other therapies and drugs and some of them are complicated and difficult to use. This painless and healthy way of enhancing sperm movement and count can be used by the male himself conveniently and at home to improve his chance of fertilizing an ovum.Trial registration: NCT, NCT04173052. Registered 21 November 2019 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04173052

Acute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model

Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level immediately after ICD electrical shocks using a proteomic approach. ICD were surgically implanted in 10 individuals of a healthy male sheep model: a control group (N = 5) without any shock delivery and a shock group (N = 5) with the delivery of 5 consecutive shocks at 41 J. Myocardial tissue samples were collected at the right-ventricle apex near to the lead coil and at the right ventricle basal free wall region. Global quantitative proteomics experiments on myocardial tissue samples were performed using mass spectrometry techniques. Proteome was significantly modified after electrical shock and several mechanisms were associated: protein, DNA and membrane damages due to extreme physical conditions induced by ICD-shock but also due to regulated cell death; metabolic remodeling; oxidative stress; calcium dysregulation; inflammation and fibrosis. These proteome modifications were seen in myocardium both “near” and “far” from electrical shock region. N-term acetylated troponin C was an interesting tissular biomarker, significantly decreased after electrical shock in the “far” region (AUC: 0.93). Our data support an acute shock-induced myocardial tissue injury which might be involved in acute paradoxical deleterious effects such as heart failure and ventricular arrhythmias.

Response of Organic Lime Mortars to Thermal and Electrical Shocks Due to Lightning Strikes

Lightning strikes are prevalent and inevitable natural phenomena that might cause damages during interaction with building structures and, in some cases, culminate in fires. During the last decades, several lightning strikes have caused considerable damages to cultural and heritage buildings. Furthermore, recent studies indicated a plausible connection between climate changes due to global warming and variations in the frequency and intensity of lightning. The evaluation of the structural efficiency and resilience of cultural buildings to global changes and natural risks appears significant in the light of the current scientific debate. This research aims at the assessment of lightning strikes’ effects on ancient heritage binding materials through the characterization of their thermal and electrical conductivity properties. This study focused on the performance evaluation of green and low-cost mortars based on the use of organic additives. Lime samples were reverse engineered by using a mixture of organics (fig, jaggery, black grape, banana, kadukai), which comprises the most common additives used in traditional Indian mortars. The reliability of the organic mixture in enhancing the resilience of masonry to lightning strikes was analyzed by using electromagnetic field simulation.

Epoxidized Percentage of CTBN (ECTBN) Double Bonds for the Application of Layering in Composite Industries and Insulation of Electronic Chips, Electrochemical Sensors

Epoxidation os liquid carboxyl-terminated butadiene acrylonitrile (CTBN) rubber was done using hydrogen peroxide and Acetic acid, and different degrees of epoxidation was used to curing and harden the epoxy resin. Using H-NMR and also FTIR methods, Epoxy of the double resin bonds used was investigated. According to the data obtained from these two methods, some available dual links are epoxy and ready for use in the mentioned applications. The peaks appeared at 1070, and 1230 cm-1 in the FTIR spectrum of ECTBN are attributed to the epoxy groups. In the HNMR spectrum of CTBN, two new signals have appeared at 2.69 ppm and 2.93 ppm, which are attributed to the protons of epoxy groups with Cis and trans configurations, respectively. Epoxy resin has been used as an electrical insulator for burying electronic boards and insulating telecommunication components and electrochemical sensors (paste electrodes structure and screen printed electrodes) due to its properties such as high breakdown voltage resistance, water-resistance and resistance to chemicals, resistance to thermal and electrical shocks.