scholarly journals A Delay Differential Equation Model of Hepatitis B Virus HBV Infection and Immune Control

2018 ◽  
Vol Volume-2 (Issue-5) ◽  
pp. 1678-1694
Author(s):  
Titus Ifeanyi Chinebu ◽  
Edmund Onwubiko Ezennorom ◽  
Godwin C. E. Mbah ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-15
Author(s):  
Xinchao Yang ◽  
Xiju Zong ◽  
Xingong Cheng ◽  
Zhenlai Han

The stability and bifurcation analysis for a delay differential equation of hepatitis B virus infection is investigated. We show the existence of nonnegative equilibria under some appropriated conditions. The existence of the Hopf bifurcation with delayτat the endemic equilibria is established by analyzing the distribution of the characteristic values. The explicit formulae which determine the direction of the bifurcations, stability, and the other properties of the bifurcating periodic solutions are given by using the normal form theory and the center manifold theorem. Numerical simulation verifies the theoretical results.


Mathematics ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 2069
Author(s):  
Anton V. Kovalev ◽  
Evgeny A. Viktorov ◽  
Thomas Erneux

In 1965, Statz et al. (J. Appl. Phys. 30, 1510 (1965)) investigated theoretically and experimentally the conditions under which spiking in the laser output can be completely suppressed by using a delayed optical feedback. In order to explore its effects, they formulate a delay differential equation model within the framework of laser rate equations. From their numerical simulations, they concluded that the feedback is effective in controlling the intensity laser pulses provided the delay is short enough. Ten years later, Krivoshchekov et al. (Sov. J. Quant. Electron. 5394 (1975)) reconsidered the Statz et al. delay differential equation and analyzed the limit of small delays. The stability conditions for arbitrary delays, however, were not determined. In this paper, we revisit Statz et al.’s delay differential equation model by using modern mathematical tools. We determine an asymptotic approximation of both the domains of stable steady states as well as a sub-domain of purely exponential transients.


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