The role of adrenoreceptors in the implementation of the stimulatory effect of serotonin on the gastric motor activity

Purpose of the study — study of the role of adrenoreceptors in the development of the stimulatory action of serotonin on the gastric motor activity.Materials and methods. The experiments were performed on rats (27) of the Wistar line in the surgical stage of anesthesia. Electromyogram and hydrostatic pressure in the stomach cavity were recorded using a BioAmp ML132 amplifier (Adinstruments, Australia), an Maclab 8e analog-to-digital converter (Adinstruments, Australia), a Macintosh Performa 6400/180 computer, and Chart 4.2.3. program. Serotonin injected into the body to intact animals and against the background of separate and joint blockade of α- and β-adrenoreceptors.The results of the study. In experiments on rats established that the preliminary simultaneous blockade of α- and β- adrenoreceptors leads to an increase in the stimulatory effect of the stomach with the introduction of serotonin by 58%, blockade of α-adrenoreceptors only — by 62%, β-adrenoreceptor blockade — by 89%. In intact animals, the stimulatory eff ect of serotonin is only + 26%. Simultaneous blockade of α- and β-adrenoreceptors and blockade of α-adrenoreceptors only (without serotonin administration) did not aff ect the gastric motor activity of intact animals. Blockade only β-adrenoreceptors will lead to an increase in gastric contractions by 34%.Conclusion. Intact α- and β-adrenoreceptors inhibit the stimulatory eff ect of serotonin on gastric motor activity.