The endothelial cell adhesion molecule, ESAM, is differentially expressed in non-small cell lung cancer and associates with patient survival.
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the endothelial cell adhesion molecule, ESAM, was among those whose expression was most different in human NSCLC tumors as compared to the lung. ESAM expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ESAM in patient tumors was significantly associated with worse overall survival. ESAM may be important for initiation or progression of non-small cell lung cancer in humans.
2020 ◽
2016 ◽
Vol 46
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pp. 393-393
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2013 ◽
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