scholarly journals Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus

2019 ◽  
Author(s):  
Naomi Bramhall ◽  
Garnett McMillan ◽  
Frederick Gallun ◽  
Dawn Konrad-Martin
Keyword(s):  
Animal Models ◽  
Auditory Brainstem Response ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Self Report ◽  
Auditory Input ◽  
Distortion Product ◽  
Brainstem Response ◽  
Temporal Bones ◽  
The Relationship

Tinnitus is one of the predicted perceptual consequences of cochlear synaptopathy, a type of age-, noise-, or drug-induced auditory damage that has been demonstrated in animal models to cause homeostatic changes in central auditory gain. Although synaptopathy has been observed in human temporal bones, assessment of this condition in living humans is limited to indirect non-invasive measures such as the auditory brainstem response (ABR). In animal models, synaptopathy is associated with a reduction in ABR wave I amplitude at suprathreshold stimulus levels. Several human studies have explored the relationship between wave I amplitude and tinnitus, with conflicting results. This study investigates the hypothesis that reduced peripheral auditory input due to synaptic/neuronal loss is associated with tinnitus. ABR wave I amplitude data from 193 individuals (43 with tinnitus (22%), 150 without tinnitus (78%)), who participated in up to three out of four different studies, were included in a logistic regression analysis to estimate the relationship between wave I amplitude and tinnitus at a variety of stimulus levels and frequencies. Statistical adjustment for sex and distortion product otoacoustic emissions was included in the analysis. The results suggest that smaller ABR wave I amplitudes are associated with an increased probability of reporting tinnitus.

The effect of coronavirus disease 2019 on the hearing system

2021 ◽  
pp. 1-5
Author(s):  
Ö Gedik ◽  
H Hüsam ◽  
M Başöz ◽  
N Tas ◽  
F Aksoy
Keyword(s):  
Auditory Brainstem Response ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Brainstem Response ◽  
Hearing System

Abstract Objective This study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019. Methods Twenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted. Results The pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III–V were significantly different between groups. Conclusion Coronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.

scholarly journals Temporary reduction of distortion product otoacoustic emissions (DPOAEs) immediately following auditory brainstem response (ABR)

2010 ◽  
Vol 269 (1-2) ◽  
pp. 180-185 ◽  
Author(s):  
Anand N. Mhatre ◽  
Bobby Tajudeen ◽  
Elena M. Welt ◽  
Christopher Wartmann ◽  
Glenis R. Long ◽  
...  
Keyword(s):  
Auditory Brainstem Response ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Distortion Product Otoacoustic Emissions ◽  
Temporary Reduction ◽  
Distortion Product ◽  
Brainstem Response

scholarly journals Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus

2019 ◽  
Vol 146 (5) ◽  
pp. 3849-3862 ◽  
Author(s):  
Naomi F. Bramhall ◽  
Garnett P. McMillan ◽  
Frederick J. Gallun ◽  
Dawn Konrad-Martin
Keyword(s):  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Self Report ◽  
Auditory Input ◽  
Brainstem Response

scholarly journals Envelope Following Response Measurements in Young Veterans Are Consistent With Noise-Induced Cochlear Synaptopathy

2020 ◽  
Author(s):  
Naomi Bramhall ◽  
Garnett McMillan ◽  
Sean Kampel
Keyword(s):  
Animal Models ◽  
Otoacoustic Emissions ◽  
Animal Studies ◽  
Noise Exposure ◽  
Auditory Brainstem ◽  
Auditory Nerve Fiber ◽  
Auditory Thresholds ◽  
Distortion Product ◽  
Brainstem Response ◽  
Envelope Following Response

Animal studies have demonstrated that noise exposure can lead to the loss of the synapses between the inner hair cells and their afferent auditory nerve fiber targets without impacting auditory thresholds. Although several non-invasive physiological measures appear to be sensitive to cochlear synaptopathy in animal models, including auditory brainstem response (ABR) wave I amplitude, the envelope following response (EFR), and the middle ear muscle reflex (MEMR), human studies of these measures in samples that are expected to vary in terms of the degree of noise-induced synaptopathy have resulted in mixed findings. One possible explanation for the differing results is that synaptopathy risk is lower for recreational noise exposure than for occupational or military noise exposure. The goal of this analysis was to determine if EFR magnitude and ABR wave I amplitude are reduced among young Veterans with a history of military noise exposure compared with non-Veteran controls with minimal noise exposure. EFRs and ABRs were obtained in a sample of young (19-35 years) Veterans and non-Veterans with normal audiograms and robust distortion product otoacoustic emissions (DPOAEs). Mean EFR magnitudes and ABR wave I amplitudes were reduced for Veterans compared with non-Veteran controls. These findings replicate previous ABR wave I amplitude results in young Veterans and are consistent with animal models of noise-induced cochlear synaptopathy.

Clinical Application of Otoacoustic Emissions: What do we Know about Factors Influencing Measurement and Analysis?

1994 ◽  
Vol 110 (1) ◽  
pp. 22-38 ◽  
Author(s):  
James W. Hall ◽  
Jane E. Baer ◽  
Patricia A. Chase ◽  
Mitchell K. Schwaber
Keyword(s):  
Otoacoustic Emissions ◽  
Large Scale ◽  
Auditory Brainstem ◽  
Distortion Product ◽  
Clinical Investigations ◽  
Gender And Age ◽  
Measurement And Analysis ◽  
The Everyday ◽  
Brainstem Response ◽  
Clinical Environments

Three electrophysiologic audiologic procedures-aural immittance measurement, auditory brainstem response (ABR), and otoacoustic emissions (OAE) — were first described in the 1970's. Immittance measurement and ABR have contributed importantly for years to the assessment of auditory function in children and adults, whereas OAEs have not yet been incorporated into the everyday audiology test battery. In this article, we argue that the transition from OAE measurement by hearing scientists in laboratory settings to routine application by audiologists in the clinic will be greatly facilitated by (1) comprehensive, large-scale studies of the effects of subject characteristics, such as gender and age (from infancy to advancing adulthood), on both transient evoked (TEOAE) and distortion product (DPOAE) otoacoustic emissions; (2) clinical investigations of TEOAE and DPOAE in sizeable patient populations with specific neurotologic diagnoses; (3) guidelines for OAE test protocols in clinical environments; and (4) clear criteria for OAE analysis in clinical populations.

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