Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness–Resistant Inbred Strain

Dysfunctional coping styles are involved in the development, persistence, and relapse of psychiatric diseases. Passive coping with stress challenges (helplessness) is most commonly used in animal models of dysfunctional coping, although active coping strategies are associated with generalized anxiety disorder, social anxiety disorder, panic, and phobias as well as obsessive-compulsive and post-traumatic stress disorder. This paper analyzes the development of dysfunctional active coping strategies of mice of the helplessness–resistant DBA/2J (D2) inbred strain, submitted to temporary reduction in food availability in an uncontrollable and unavoidable condition. The results indicate that food-restricted D2 mice developed a stereotyped form of food anticipatory activity and dysfunctional reactive coping in novel aversive contexts and acquired inflexible and perseverant escape strategies in novel stressful situations. The evaluation of FosB/DeltaFosB immunostaining in different brain areas of food-restricted D2 mice revealed a pattern of expression typically associated with behavioral sensitization to addictive drugs and compulsivity. These results support the conclusion that an active coping style represents an endophenotype of mental disturbances characterized by perseverant and inflexible behavior.

Reduction in Absolute Neutrophil Counts in Patient on Clozapine Infected with COVID-19

Despite its severe adverse effects, such as agranulocytosis, clozapine is the primary treatment for treatment-resistant schizophrenia. The established clozapine monitoring system has contributed to reducing agranulocytosis incidence and mortality rates. However, the pandemic coronavirus disease 2019 (COVID-19) has caused changes in the monitoring system. This review aimed to assess the current evidence on the neutrophil changes in the patient on clozapine treatment and infected with COVID-19. Individual cases reported various absolute neutrophil count (ANC) levels, normal, reduced, or elevated. No agranulocytosis case was reported. One case had a borderline moderate-severe ANC level, but the patient was in the 18-week period of clozapine treatment. A cumulative analysis of case the series initially reported inconclusive results. However, a more recent study with a larger sample size reported a significant reduction in the ANC during COVID-19 infection. Nevertheless, this effect is transient as no significant difference was found between the baseline and the post-infection period in ANC levels. In conclusion, COVID-19 is associated with a temporary reduction in ANC levels. The results supported the recommendation to reduce the frequency of clozapine monitoring in the eligible candidates. However, more data are required to confirm the current findings given the limitations, including study design, sample size, and statistical analysis.

NOVEL PHYSIOTHERAPEUTIC APPROACH TOWARDS A CASE OF COMPLEX MULTIPLE FRACTURE

A straddle fracture of the pelvis is a fracture of the superior and inferior pubic rami which is considered an unstable injury. Injuries most often associated with straddle fracture include sacral fracture, neurological injury, pelvic ring disturbance, lumbar spine fracture, and severe soft tissue injury. A pelvic fracture can happen through the mechanism of either moderate or medium intensity effects. This can range in magnitude from relatively minor mishaps to moderately traumatic fractures that are potentially fatal. L5 transverse process fracture are often associated with pelvic ring fractures, which may indicate high energy trauma. A 35-year-old female with a left-sided straddle fracture, a sacral ala fracture associated with an L5 transverse process fracture L5 was diagnosed by orthopaedic surgeon, on X-ray after a slip and fall sustaining injury to pelvic region, on which open reduction and internal fixation with a 5-hole pre-contoured plate was placed. Temporary reduction was done by K-wire and sacral ala fracture was fixed with 2 CC screws. Post operatively the patient had impaired limb movements and inability to perform daily activities. After operation, patient was managed with physical therapy treatment comprising of static regimens, progressing to dynamic exercises, electrotherapeutic techniques, strengthening exercises, gait exercise for duration of 10 weeks. Patient was given physiotherapy regime for 5 days per week for 10 weeks. This study shows that the operative method and timely recovery in physical therapy contributed to the progress of ROM, strength of muscle, functional activities progressively, which successfully led to further recovery.

Sonic Drilling with Use of a Cavitation Hydraulic Vibrator

Sonic drilling is a soil penetration technique that strongly reduces friction on the drill string and drill bit due to liquefaction, inertia effects and a temporary reduction of porosity of the soil. Modern studies to assess the effect of the vibration frequency of the drill bit on the rock fragmentation in experimental and theoretical works on drilling various rocks by the sonic method have shown that vibration frequencies of ~ 1.4 kHz are the most beneficial for ensuring the maximum drilling speed in hard rocks. The above frequencies of excitation of vibrations of the drill bit can be achieved by using a cavitation hydrovibrator. The cavitation hydrovibrator is the Venturi tube of special geometry that converts a stationary fluid (flushing mud) flow into an oscillatory stalling cavitation flow and hydrovibrator structure longitudinal vibrations. The drill bit vibration accelerations are realized in such a drill string, leading to the destruction of rock. Efficient removal of rock particles from the bottomhole is achieved due to high-frequency shock self-oscillations of mud pressure exceeding the steady-state pressure at the generator inlet. The cavitation hydraulic vibrator lacks the main disadvantages of submersible hydraulic hammers.

Ways to Overcome Poverty and Income Inequality in the Context of New Global Challenges: the Most Important Conclusions for Ukraine

The article examines the risks of deepening poverty and income inequality that arise from global challenges of population aging, job losses due to shrinking sales markets, trade wars, long-term quarantine and compliance with the safe distancing of people as part of restrictive measures against the spread of COVID–19, the nature of employment (remote work, temporary reduction of labor migration), and other norms in the fight against the dangerous contagious disease. Given the facts that the prevention of spreading and localization of dangerous diseases, their treatment, and the rehabilitation of patients affect all segments of the population, have negative effects on all areas of people’s lives and also add to the increase of socio-economic risks, including poverty and inequality, the study of this issue is extremely relevant. The financial implications of these challenges for many households lead to falling real incomes, and an increase in costs and debts, and their non-repayment, which generally cause sudden poverty and increasing inequality of income and property. Purpose of the article: To investigate the risks of poverty, including sudden poverty, the inequality of household incomes amid the fight against the COVID–19 pandemic, and it identifies ways to overcome them. Methods: A review of the scientific literature, a presentation of statistical data, and statistical research. Findings & Value added: As a result of research, a list of new risks of poverty and income inequality is outlined, and preliminary assessments of the consequences of the COVID–19 for households are summarized; signs of short-term loss are generalized; the solvency of households as a possible precondition for sudden poverty is evaluated; cross‑country comparisons of poverty risk are made; the scheme of state aid to improve living standards of people during the outbreak of new dangerous diseases in the EU and Ukraine is generalized; ways to overcome poverty and income inequality are substantiated to restore the resilience of financially vulnerable households and ensuring the development of human capital.

Decline in Share Prices of Energy and Fuel Companies on the Warsaw Stock Exchange as a Reaction to the COVID-19 Pandemic

Many factors influence the prices of energy commodities and the value of energy and fuel companies. Among them there are the following factors: economic, social, environmental and political, and recently also the COVID-19 pandemic. The aim of the paper is to examine what the probability and intensity of a decrease in the prices of shares of energy and fuel companies listed on the Warsaw Stock Exchange (Poland) was during the first wave of the pandemic in the first quarter of 2020. The study used the survival analysis methods: the Kaplan-Meier estimator, the test of equality of duration curves and the Cox non-proportional hazards model. The analysis showed that the probability and intensity of price decline of energy and fuel companies in the initial period was the same as that of other companies. The differences become apparent only after 50 days from the established maximum of their value. The risk of price declines in energy and fuel companies increased significantly. This situation was related both to a temporary reduction in demand for energy and fuels, pandemic restrictions introduced in individual countries and the behaviour of stock market investors.

Wildfire Impacts on Groundwater Aquifers: A Case Study of the 1996 Honey Boy Fire in Beaver County, Utah, USA

It is well known that wildfires destroy vegetation and form soil crusts, both of which increase stormwater runoff that accelerates erosion, but less attention has been given to wildfire impacts on groundwater aquifers. Here, we present a systematic study across the contiguous United States to test the hypothesis that wildfires reduce infiltration, indicated by temporary reductions in groundwater levels. Geographic information systems (GIS) analysis performed using structured queried language (SQL) categorized wildfires by their proximity to wells with publicly available monitoring data. Although numerous wildfires were identified with nearby monitoring wells, most of these data were confounded by unknown processes, preventing a clear acceptance or rejection of the hypothesis. However, this analysis did identify a particular case study, the 1996 Honey Boy Fire in Beaver County, Utah, USA that supports the hypothesis. At this site, daily groundwater data from a well located 790 m from the centroid of the wildfire were used to assess the groundwater level before and after the wildfire. A sinusoidal time series adjusted for annual precipitation matches groundwater level fluctuations before the wildfire but cannot explain the approximately two-year groundwater level reduction after the wildfire. Thus, for this case study, there is a correlation, which may be causal, between the wildfire and temporary reduction in groundwater levels. Generalizing this result will require further research.

A Flavor of the Future of GI Endoscopy—New Solutions Shape the Field of Modern Gastrointestinal Care

Gastrointestinal (GI) cancers remain high on the list of the leading causes of death worldwide; however, the recent emergence of new and ongoing global healthcare threats, such as the COVID-19 pandemic, has led to a temporary reduction in elective endoscopic procedures [...]