Expression of the interferon regulatory factor 6 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.

Non-small cell lung cancer, classified as adenocarcinomas or squamous cell lung carcinomas, is the major cause of cancer death in the United States and worldwide (1). To understand the most significant transcriptional differences between adenocarcinomas and squamous cell lung carcinomas, we mined published microarray data from two separate studies (2, 3). We identified interferon regulatory factor 6 (IRF6) as a distinguishing transcriptional feature of squamous cell lung carcinomas, suggesting the biology of IRF6 may be relevant to the pathways critical for the development or maintenance of squamous cell lung carcinomas but not of adenocarcinomas. IRF6 expression was significantly correlated with prognosis of patients with NSCLC, as patients with low tumor expression of IRF6 possessed significantly longer median overall survival than those with high tumor expression of IRF6. These analyses will also provide novel tools for diagnostic approaches and for guidance of treatment regimens for a cancer with dismal outlook.

Expression of ceramide synthase 3 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.

10.31219/osf.io/kme2s ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Squamous Cell ◽

Lung Carcinoma ◽

The United States ◽

Small Cell ◽

Ceramide Synthase ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinomas ◽

Non-small cell lung cancer, classified as adenocarcinomas or squamous cell lung carcinomas, is the major cause of cancer death in the United States and worldwide (1). To understand the most significant transcriptional differences between adenocarcinomas and squamous cell lung carcinomas, we mined published microarray data from two separate studies (2, 3). We identified ceramide synthase 3 (CERS3) as a distinguishing transcriptional feature of squamous cell lung carcinomas, suggesting the biology of CERS3 may be relevant to the pathways critical for the development or maintenance of squamous cell lung carcinomas but not of adenocarcinomas. CERS3 expression was significantly correlated with prognosis of patients with NSCLC, as patients with low tumor expression of CERS3 possessed significantly longer median overall survival than those with high tumor expression of CERS3. These analyses will also provide novel tools for diagnostic approaches and for guidance of treatment regimens for a cancer with dismal outlook.

Expression of desmocollin 3 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.

10.31219/osf.io/tf329 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Squamous Cell ◽

Lung Carcinoma ◽

The United States ◽

Small Cell ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinomas ◽

Treatment Regimens ◽

Non-small cell lung cancer, classified as adenocarcinomas or squamous cell lung carcinomas, is the major cause of cancer death in the United States and worldwide (1). To understand the most significant transcriptional differences between adenocarcinomas and squamous cell lung carcinomas, we mined published microarray data from two separate studies (2, 3). We identified desmocollin 3 (DSC3) as a distinguishing transcriptional feature of squamous cell lung carcinomas, suggesting the biology of DSC3 may be relevant to the pathways critical for the development or maintenance of squamous cell lung carcinomas but not of adenocarcinomas. DSC3 expression was significantly correlated with prognosis of patients with NSCLC, as patients with low tumor expression of DSC3 possessed significantly longer median overall survival than those with high tumor expression of DSC3. These analyses will also provide novel tools for diagnostic approaches and for guidance of treatment regimens for a cancer with dismal outlook.

Expression of the visinin-like protein-1 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.

10.31219/osf.io/r6dbz ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Squamous Cell ◽

Lung Carcinoma ◽

The United States ◽

Small Cell ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinomas ◽

Treatment Regimens ◽

Non-small cell lung cancer, classified as adenocarcinomas or squamous cell lung carcinomas, is the major cause of cancer death in the United States and worldwide (1). To understand the most significant transcriptional differences between adenocarcinomas and squamous cell lung carcinomas, we mined published microarray data from two separate studies (2, 3). We identified visinin-like protein-1 (VSNL1) as a distinguishing transcriptional feature of squamous cell lung carcinomas, suggesting the biology of VSNL1 may be relevant to the pathways critical for the development or maintenance of squamous cell lung carcinomas but not of adenocarcinomas. VSNL1 expression was significantly correlated with prognosis of patients with NSCLC, as patients with low tumor expression of VSNL1 possessed significantly longer median overall survival than those with high tumor expression of VSNL1. These analyses will also provide novel tools for diagnostic approaches and for guidance of treatment regimens for a cancer with dismal outlook.

Expression of desmoglein 3 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.

10.31219/osf.io/ntp9c ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Squamous Cell ◽

Lung Carcinoma ◽

The United States ◽

Small Cell ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinomas ◽

Treatment Regimens ◽

Desmoglein 3

Non-small cell lung cancer, classified as adenocarcinomas or squamous cell lung carcinomas, is the major cause of cancer death in the United States and worldwide (1). To understand the most significant transcriptional differences between adenocarcinomas and squamous cell lung carcinomas, we mined published microarray data from two separate studies (2, 3). We identified desmoglein 3 (DSG3) as a distinguishing transcriptional feature of squamous cell lung carcinomas, suggesting the biology of DSG3 may be relevant to the pathways critical for the development or maintenance of squamous cell lung carcinomas but not of adenocarcinomas. DSG3 expression was significantly correlated with prognosis of patients with NSCLC, with patients expressing low levels of DSG3 possessing significantly longer median overall survival. These analyses will also provide novel tools for diagnostic approaches and for guidance of treatment regimens for a cancer with dismal outlook.

Cytology of Lung Carcinomas with Subtyping of Non-small Cell lung Carcinoma (NSCLC)

International Journal of Science and Research (IJSR) ◽

10.21275/v5i2.nov161656 ◽

2016 ◽

Vol 5 (2) ◽

pp. 1940-1945

Keyword(s):

Lung Carcinoma ◽

Small Cell ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Lung Carcinomas

Comparison of Differential Diagnosis of Lung Cancer by Diffuse Weighted Imaging and Sagittal Imaging with Short Inversion Recovery Sequence

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3356 ◽

2021 ◽

Vol 11 (3) ◽

pp. 822-826

Author(s):

Wei Zhang ◽

Qingyu Cai ◽

Guoli Wei

Keyword(s):

Lung Cancer ◽

Differential Diagnosis ◽

Squamous Cell ◽

Lung Carcinoma ◽

Small Cell ◽

Small Cell Lung ◽

Recovery Sequence ◽

Cell Lung Carcinoma ◽

Diagnosis Of Lung Cancer

The differential diagnosis of advanced lung cancer is difficult in clinical practice. Our study aims to compare the value of diffusion weighted imaging (DWI) with short-term inversion recovery sequence (STIR) for sagittal imaging in the differential diagnosis of lung cancer. 149 patients with non-small cell lung carcinoma (NSCLC) were enrolled and underwent DWI and STIR sagittal imaging. To quantify cancer types, we evaluated the apparent diffusion coefficient (ADC) value on DWI and the contrast ratio (CRs) on sagittal imaging. The ADC values of subclasses in NSCLC were significantly higher than small cell lung carcinoma (SCLC) (p <0.01). The mean CRs were 1.59 for SCLC and 1.30 for NSCLC with a significant difference (p < 0.01). Large cell carcinomas (LCC) and adenocarcinomas have significant differences compared to small cell carcinomas (SCC) without difference between squamous cell carcinomas (p > 0.05); this is also the case for CRs. Squamous cell carcinoma and adenocarcinoma have significant differences compared to SCC without difference in LCC (p > 0.05). Qualitative evaluation of the feasible thresholds DWI and STIR showed that the thresholds were 0.9810−3 mm2/s and 1.37 respectively. The specificity and accuracy was 78.5% is 85.3% for DWI, which was significantly higher than STIR (56.3% and 61.0%). The combination of DWI and STIR sequences was superior to DWI alone with an accuracy rate of 94.3%. DWI is more helpful than STIR in differentiating SCLC and NSCLC, and their combined use can significantly improve diagnosis accuracy.