scholarly journals Optic atrophy 1 (OPA1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Microarray Data ◽  
Optic Atrophy ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Potential Therapeutic Target ◽  
Gene Encoding ◽  
The Brain

Preservation of mitochondrial integrity is essential for prevention of cell death (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding optic atrophy 1, OPA1, a gene with functions in the stabilization of the mitochondrial cristae (8), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. OPA1 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals Apelin is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the peptide apelin, APLN, was among those most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. APLN may be of relevance to the biology underlying metastasis to the brain in humans with metastatic breast cancer.

scholarly journals The KAT8 regulatory NSL subunit complex subunit 2 (KANSL2) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Potential Therapeutic Target ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
Cis Acting ◽  
The Brain

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the KAT8 regulatory NSL complex subunit 2, KANSL2, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. KANSL2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals RALGPS1 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Therapeutic Target ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Potential Therapeutic Target ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that RALGPS1 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. RALGPS1 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals SLC1A3 (EAAT1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the glutamate transport SLC1A3 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. SLC1A3, and its function in the transport of glutamate (6) may be relevant to the biology underlying metastasis of competent breast cancer clones to the brain.

scholarly journals MMP13 is differentially expressed and down-regulated in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Matrix Metalloproteinase 13 ◽  
The Matrix ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the matrix metalloproteinase 13, MMP13, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MMP13 may be of relevance to the biology underlying metastasis to the brain in humans with metastatic breast cancer. MMP13 now joins MMP14, MMP11 and MMP2 among matrix metalloproteinases we have found to be differentially expressed and down-regulated in the brain metastases of humans with metastatic breast cancer (6-8).

scholarly journals The methyl CpG-binding protein MeCP2 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Binding Protein ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
The Brain ◽  
Protein Mecp2

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6-8) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the methyl CpG-binding protein MeCP2, a molecule with critical epigenetic functions in the brain (9, 10), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MeCP2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals Telomerase-associated protein TEP1 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the telomerase-associated protein encoded by TEP1 (6) was among the genes whose expression was most different in the brain metastases of patients with brain metastatic breast cancer as compared to primary tumors of the breast. TEP1 may be relevant to processes underlying metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

scholarly journals Glycine-N-acyltransferase (GLYAT) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the glycine-N-acyltransferase, encoded by GLYAT, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Molecular functions and down-regulation of GLYAT may be important for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

scholarly journals Factor XII (Hageman factor) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Coagulation Factor ◽  
Clinical Problem ◽  
Factor Xii ◽  
Gene Encoding ◽  
Hageman Factor ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the coagulation factor XII (FXII), also known as Hageman factor, F12, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. FXII may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals The histone arginine demethylase JMJD6 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
Cis Acting ◽  
Arginine Demethylase ◽  
The Brain

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the histone arginine demethylase JMJD6 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. JMJD6 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

Sign in / Sign up

Export Citation Format

Share Document