scholarly journals The methyl CpG-binding protein MeCP2 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Binding Protein ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
The Brain ◽  
Protein Mecp2

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6-8) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the methyl CpG-binding protein MeCP2, a molecule with critical epigenetic functions in the brain (9, 10), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MeCP2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals The KAT8 regulatory NSL subunit complex subunit 2 (KANSL2) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Potential Therapeutic Target ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
Cis Acting ◽  
The Brain

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the KAT8 regulatory NSL complex subunit 2, KANSL2, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. KANSL2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals The histone arginine demethylase JMJD6 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
Cis Acting ◽  
Arginine Demethylase ◽  
The Brain

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the histone arginine demethylase JMJD6 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. JMJD6 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals Coding and non-coding transcripts produced at the TBX5 locus are differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
Cis Acting ◽  
The Brain

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the T-box transcription factor TBX5 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. Differential expression of anti-sense transcription at the TBX5 locus in brain metastases in patients with metastatic breast cancer was also observed. TBX5 may be of relevance to the biology underlying metastasis to the brain.

scholarly journals MMP13 is differentially expressed and down-regulated in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Matrix Metalloproteinase 13 ◽  
The Matrix ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the matrix metalloproteinase 13, MMP13, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MMP13 may be of relevance to the biology underlying metastasis to the brain in humans with metastatic breast cancer. MMP13 now joins MMP14, MMP11 and MMP2 among matrix metalloproteinases we have found to be differentially expressed and down-regulated in the brain metastases of humans with metastatic breast cancer (6-8).

scholarly journals Optic atrophy 1 (OPA1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Microarray Data ◽  
Optic Atrophy ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Potential Therapeutic Target ◽  
Gene Encoding ◽  
The Brain

Preservation of mitochondrial integrity is essential for prevention of cell death (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding optic atrophy 1, OPA1, a gene with functions in the stabilization of the mitochondrial cristae (8), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. OPA1 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals Apelin is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the peptide apelin, APLN, was among those most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. APLN may be of relevance to the biology underlying metastasis to the brain in humans with metastatic breast cancer.

scholarly journals Factor XII (Hageman factor) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Coagulation Factor ◽  
Clinical Problem ◽  
Factor Xii ◽  
Gene Encoding ◽  
Hageman Factor ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the coagulation factor XII (FXII), also known as Hageman factor, F12, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. FXII may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

scholarly journals SLC1A3 (EAAT1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
The Brain

Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the glutamate transport SLC1A3 was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. SLC1A3, and its function in the transport of glutamate (6) may be relevant to the biology underlying metastasis of competent breast cancer clones to the brain.

scholarly journals FGF12 is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the fibroblast growth factor 12, encoded by FGF12, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues. FGF12 mRNA expression was significantly higher in brain metastatic tissues as compared to primary tumors of the breast. Up-regulation of FGF12 expression may contribute to metastasis of tumor cells from the breast to the brain in humans with metastatic breast cancer.

scholarly journals C1R is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the complement component 1, r subcomponent, encoded by C1R, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues. C1R mRNA was present at significantly reduced quantities in brain metastatic tissues as compared to primary tumors of the breast. Down-regulation of C1R expression may contribute to metastasis of tumor cells from the breast to the brain in humans with metastatic breast cancer.

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