Factor XII (Hageman factor) is over-expressed in brain metastatic breast cancer.
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Brain metastases are a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the coagulation factor XII (FXII), also known as Hageman factor, F12, was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. FXII may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.
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